https://m2.mtmt.hu/ hun 2026-09-20 17:23 JournalArticle 33692946 APPROVED true Export Date: 20 March 2023 Correspondence Address: Józsi, M.; Department of Immunology, Hungary; email: mihaly.jozsi@ttk.elte.hu 0 false 2026-09-09T14:12:48.451+0000 2025-09-25T17:24:56.297+0000 2023-03-10T12:44:38.062+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Molnár-Taga Márta (SE 4-es admin) true 10062250 2026-06-29T14:01:43.424+0000 2026-06-29T14:01:43.424+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Matola, Alexandra T. true true /api/journal/10023324 REVIEWED FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 14 1113015 1113015 12 2023 Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA). Overactivation of the complement system seems to be part of the pathogenesis of RA, and autoantibodies against the pathway initiators C1q and MBL, and the regulator of the complement alternative pathway, factor H (FH), were previously reported. Our aim was to analyze the presence and role of autoantibodies against complement proteins in a Hungarian RA cohort. To this end, serum samples of 97 ACPA-positive RA patients and 117 healthy controls were analyzed for autoantibodies against FH, factor B (FB), C3b, C3-convertase (C3bBbP), C1q, MBL and factor I. In this cohort, we did not detect any patient with FH autoantibodies but detected C1q autoantibodies in four patients, MBL autoantibodies in two patients and FB autoantibodies in five patients. Since the latter autoantibodies were previously reported in patients with kidney diseases but not in RA, we set out to further characterize such FB autoantibodies. The isotypes of the analyzed autoantibodies were IgG2, IgG3, IgGκ, IgGλ and their binding site was localized in the Bb part of FB. We detected in vivo formed FB–autoanti-FB complexes by Western blot. The effect of the autoantibodies on the formation, activity and FH-mediated decay of the C3 convertase in solid phase convertase assays was determined. In order to investigate the effect of the autoantibodies on complement functions, hemolysis assays and fluid phase complement activation assays were performed. The autoantibodies partially inhibited the complement-mediated hemolysis of rabbit red blood cells, inhibited the activity of the solid phase C3-convertase and C3 and C5b-9 deposition on complement activating surfaces. In summary, in ACPA-positive RA patients we identified FB autoantibodies. The characterized FB autoantibodies did not enhance complement activation, rather, they had inhibitory effect on complement. These results support the involvement of the complement system in the pathomechanism of RA and raise the possibility that protective autoantibodies may be generated in some patients against the alternative pathway C3 convertase. However, further analyses are needed to assess the exact role of such autoantibodies. Funding 2024475 /api/funding/2024475 (NKFIH-1157/8/2019, D11206) false true Funding 2024476 /api/funding/2024476 (K125219) Támogató: OTKA false true Funding 2024477 /api/funding/2024477 (0106307) Támogató: MTA false true Funding 2024478 /api/funding/2024478 (FIEK_16-1-2016-0005) false true true 2023 true true true false true false GOLD 2026-09-09 true https://doi.org/10.3389/fimmu.2023.1113015 10 0 10 9 1 10 10 9 9 10 10 9 9 9 1 0 10 9 10 9 0 4 4 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 8 7 8 7 2026 0 1 1 1 1 Q1 false 10019323,10085067,10001984,10035041 false false false 2023-03-09T12:44:44.332+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Budai Irgalmasrendi Kórház Kht.; Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Immunológiai Tanszék (ELTE / TTK / Bio_I); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); MTA-ELTE Komplement Kutatócsoport (ELTE / TTK / Bio_I / Imm_Tsz); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 6 33 7 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 106969560 /api/authorship/106969560 Matola, Alexandra T. [Matola, Alexandra Tünde (Immunológia), szerző] Immunológiai Tanszék (ELTE / TTK / Bio_I); MTA-ELTE Komplement Kutatócsoport (ELTE / TTK / Bio_I / Imm_Tsz) 1 0.143 true false false Author 10085067 /api/author/10085067 Matola Alexandra Tünde (Immunológia) Matola Alexandra Tünde true true Matola Alexandra T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969561 /api/authorship/106969561 Fülöp, Angéla 2 0.14285715 false false false Fülöp Angéla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969562 /api/authorship/106969562 Rojkovich, Bernadette [Rojkovich, Bernadette (reumatológia), szerző] Budai Irgalmasrendi Kórház Kht. 3 0.14285715 false false false Author 10048660 /api/author/10048660 Rojkovich Bernadette (reumatológia) Rojkovich Bernadette true 10048660 true Rojkovich Bernadette true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969563 /api/authorship/106969563 Nagy, György [Nagy, György (Immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 4 0.143 false false false Author 10025749 /api/author/10025749 Nagy György (Immunológia) Nagy György true 10025749 true Nagy György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969564 /api/authorship/106969564 Sármay, Gabriella [Sármay, Gabriella (Immunológia), szerző] Immunológiai Tanszék (ELTE / TTK / Bio_I) 5 0.143 false false false Author 10001984 /api/author/10001984 Sármay Gabriella (Immunológia) Sármay Gabriella true 10001984 true Sármay Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969565 /api/authorship/106969565 Józsi, Mihály** ✉ [Józsi, Mihály (Immunológia), szerző] Immunológiai Tanszék (ELTE / TTK / Bio_I); MTA-ELTE Komplement Kutatócsoport (ELTE / TTK / Bio_I / Imm_Tsz) 6 0.143 false true true Author 10019323 /api/author/10019323 Józsi Mihály (Immunológia) Józsi Mihály true 10019323 true Józsi Mihály true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106969566 /api/authorship/106969566 Uzonyi, Barbara [Uzonyi, Barbara (Immunológia), szerző] Immunológiai Tanszék (ELTE / TTK / Bio_I); MTA-ELTE Komplement Kutatócsoport (ELTE / TTK / Bio_I / Imm_Tsz) 7 0.143 false true false Author 10035041 /api/author/10035041 Uzonyi Barbara (Immunológia) Uzonyi Barbara true 10035041 true Uzonyi Barbara true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23217342 /api/publicationidentifier/23217342 DOI: 10.3389/fimmu.2023.1113015 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fimmu.2023.1113015 https://doi.org/10.3389/fimmu.2023.1113015 false true PublicationIdentifier 23255473 /api/publicationidentifier/23255473 WoS: 000943389700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000943389700001 https://www.webofscience.com/wos/woscc/full-record/000943389700001 false true PublicationIdentifier 23255472 /api/publicationidentifier/23255472 Scopus: 85149694961 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85149694961 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149694961 false true PublicationIdentifier 23217343 /api/publicationidentifier/23217343 PubMed: 36891314 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36891314 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36891314&dopt=Abstract false true Classification 12215 /api/classification/12215 Klinikai orvostan true true SjrRating 11386651 /api/sjrrating/11386651 sjr:Q1 (2023) Scopus - Immunology FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 Scopus - Immunology true 2403 true Q1 DIRECT true true Reference 39227799 /api/reference/39227799 1. 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Autoantibodies against complement factor B in rheumatoid arthritis. (2023) FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10085067"><a href="/gui2/?type=authors&mode=browse&sel=10085067" target="_blank">Matola Alexandra T. (<span class="authorship-author-name">Matola Alexandra Tünde</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Immunológiai Tanszék">Imm_Tsz</span>/MTA-ELTE Komplement Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fülöp Angéla </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048660"><a href="/gui2/?type=authors&mode=browse&sel=10048660" target="_blank">Rojkovich Bernadette (<span class="authorship-author-name">Rojkovich Bernadette</span> <span class="authorAux-mtmt"> reumatológia</span>) </a> </span> <span class="author-affil">Budai Irgalmasrendi Kórház Kht.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001984"><a href="/gui2/?type=authors&mode=browse&sel=10001984" target="_blank">Sármay Gabriella (<span class="authorship-author-name">Sármay Gabriella</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019323"><a href="/gui2/?type=authors&mode=browse&sel=10019323" target="_blank">Józsi Mihály^** ✉ (<span class="authorship-author-name">Józsi Mihály</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Immunológiai Tanszék">Imm_Tsz</span>/MTA-ELTE Komplement Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035041"><a href="/gui2/?type=authors&mode=browse&sel=10035041" target="_blank">Uzonyi Barbara (<span class="authorship-author-name">Uzonyi Barbara</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Immunológiai Tanszék; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/<span title="Immunológiai Tanszék">Imm_Tsz</span>/MTA-ELTE Komplement Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33692946" target="_blank">Autoantibodies against complement factor B in rheumatoid arthritis</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 1113015. 12 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fimmu.2023.1113015" target="_blank" href="https://doi.org/10.3389/fimmu.2023.1113015"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000943389700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000943389700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149694961" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149694961"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36891314" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36891314&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 9 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33692946&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33692946</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH-1157/8/2019, D11206), (K125219) Támogató: OTKA, (0106307) Támogató: MTA, (FIEK_16-1-2016-0005) </div> <div class="lastModified">Utolsó módosítás: 2025.09.25. 19:24 Szabó Regina (ELTE TTK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 20 March 2023 Correspondence Address: Józsi, M.; Department of Immunology, Hungary; email: mihaly.jozsi@ttk.elte.hu</pre> </div></div>