https://m2.mtmt.hu/ eng 2026-09-23 08:39 JournalArticle 33690496 VALIDATED true Export Date: 13 August 2023 Correspondence Address: Adany, R.; ELKH-DE Public Health Research Group, Hungary; email: adany.roza@med.unideb.hu Chemicals/CAS: glucose, 50-99-7, 84778-64-3, 8027-56-3; lipid, 66455-18-3; mitogen activated protein kinase, 142243-02-5; triacylglycerol lipase, 9001-62-1 0 false 2026-07-14T12:09:53.640+0000 2023-04-14T08:15:44.482+0000 2023-03-09T11:36:00.264+0000 true 10061786 Pikó Péter /api/author/10061786 Author Péter Pikó (Népegészségügy) true 10061786 2025-09-17T12:32:33.941+0000 2025-09-17T12:32:33.941+0000 2023-04-14T08:12:34.975+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Piko, Peter true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 6 5209 5209 16 2023 A specific phenotypic variant of obesity is metabolically healthy (MHO), which is characterized by normal blood pressure and lipid and glucose profiles, in contrast to the metabolically unhealthy variant (MUO). The genetic causes underlying the differences between these phenotypes are not yet clear. This study aims to explore the differences between MHO and MUO and the contribution of genetic factors (single nucleotide polymorphisms—SNPs) in 398 Hungarian adults (81 MHO and 317 MUO). For this investigation, an optimized genetic risk score (oGRS) was calculated using 67 SNPs (related to obesity and to lipid and glucose metabolism). Nineteen SNPs were identified whose combined effect was strongly associated with an increased risk of MUO (OR = 1.77, p < 0.001). Four of them (rs10838687 in MADD, rs693 in APOB, rs1111875 in HHEX, and rs2000813 in LIPG) significantly increased the risk of MUO (OR = 1.76, p < 0.001). Genetic risk groups based on oGRS were significantly associated with the risk of developing MUO at a younger age. We have identified a cluster of SNPs that contribute to the development of the metabolically unhealthy phenotype among Hungarian adults suffering from obesity. Our findings emphasize the significance of considering the combined effect(s) of multiple genes and SNPs in ascertaining cardiometabolic risk in obesity in future genetic screening programs. Funding 2025510 /api/funding/2025510 A magyar gazdaság versenyképességének növelése a lakosság egészségi állapotát javító népegészségü...(GINOP-2.3.2-15-2016-00005) Funder: GINOP false true Funding 2025511 /api/funding/2025511 (TK2016-78) false true Funding 2025512 /api/funding/2025512 (TKCS-2021/32) false true Funding 2025513 /api/funding/2025513 (135784) Funder: NRDIO false true true 2023 true true true false false GOLD 2026-07-14 true https://doi.org/10.3390/ijms24065209 8 0 8 8 1 8 8 6 7 8 8 8 8 8 0 0 8 8 8 8 0 6 6 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 1 1 1 1 2025 0 4 4 4 4 2026 0 2 2 2 2 D1 false 10061786,10039469 false false false 2023-04-13T08:12:34.376+0000 ELKH-DE Népegészségügyi Kutatócsoport (DE / ÁOK / NegJtI); Epidemiológiai és Surveillance Központ (SE / KSZE); Népegészség- és Járványtani Intézet (DE / ÁOK); Népegészségtani Intézet (SE / AOK / I) 4 22 4 4 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 106960354 /api/authorship/106960354 Piko, Peter [Pikó, Péter (Népegészségügy), author] Center of Epidemiology and Survaillance (SU / KSZE); ELKH-DE Public Health Research Group (UD / NegJtI) 1 0.25 true false false Author 10061786 /api/author/10061786 Péter Pikó (Népegészségügy) Pikó Péter true 10061786 true Piko Peter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106960355 /api/authorship/106960355 Llanaj, Erand [Llanaj, Erand (Epidemiologist), author] ELKH-DE Public Health Research Group (UD / NegJtI) 2 0.25 false false false Author 10060835 /api/author/10060835 Erand Llanaj (Epidemiologist) Llanaj Erand true 10060835 true Llanaj Erand true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106960356 /api/authorship/106960356 Nagy, Karoly [Nagy, Károly (népegészségügy), author] Népegészség- és Járványtani Intézet (UD) 3 0.25 false false false Author 10039469 /api/author/10039469 Károly Nagy (népegészségügy) Nagy Károly true 10039469 true Nagy Karoly true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106960357 /api/authorship/106960357 Adany, Roza ✉ [Ádány, Róza (Népegészségügy, g...), author] Department of Public Health (SU / FM / I); Center of Epidemiology and Survaillance (SU / KSZE); ELKH-DE Public Health Research Group (UD / NegJtI) 4 0.25 false true true Author 1131057 /api/author/1131057 Róza Ádány (Népegészségügy, genetikai epidemiológia) Ádány Róza true 1131057 true Adany Roza true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 23210728 /api/publicationidentifier/23210728 DOI: 10.3390/ijms24065209 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24065209 https://doi.org/10.3390/ijms24065209 false true PublicationIdentifier 23373168 /api/publicationidentifier/23373168 WoS: 000957873700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000957873700001 https://www.webofscience.com/wos/woscc/full-record/000957873700001 true true PublicationIdentifier 23361804 /api/publicationidentifier/23361804 Scopus: 85151435418 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85151435418 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151435418 false true PublicationIdentifier 23373173 /api/publicationidentifier/23373173 PubMed: 36982283 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36982283 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36982283&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 39198120 /api/reference/39198120 1. 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Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 6<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10061786"><a href="/gui2/?type=authors&mode=browse&sel=10061786" target="_blank">Piko Peter (<span class="authorship-author-name">Pikó Péter</span> <span class="authorAux-mtmt"> Népegészségügy</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Center of Epidemiology and Survaillance; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/ELKH-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060835"><a href="/gui2/?type=authors&mode=browse&sel=10060835" target="_blank">Llanaj Erand (<span class="authorship-author-name">Llanaj Erand</span> <span class="authorAux-mtmt"> Epidemiologist</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/ELKH-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039469"><a href="/gui2/?type=authors&mode=browse&sel=10039469" target="_blank">Nagy Karoly (<span class="authorship-author-name">Nagy Károly</span> <span class="authorAux-mtmt"> népegészségügy</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Népegészség- és Járványtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1131057"><a href="/gui2/?type=authors&mode=browse&sel=1131057" target="_blank">Adany Roza ✉ (<span class="authorship-author-name">Ádány Róza</span> <span class="authorAux-mtmt"> Népegészségügy, genetikai epidemiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Center of Epidemiology and Survaillance; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/ELKH-DE Public Health Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33690496" target="_blank">Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">6</span> <span class="page"> Paper 5209. 16 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24065209" target="_blank" href="https://doi.org/10.3390/ijms24065209"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000957873700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000957873700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151435418" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151435418"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36982283" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36982283&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 8 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33690496&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33690496</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> A magyar gazdaság versenyképességének növelése a lakosság egészségi állapotát javító népegészségü...(GINOP-2.3.2-15-2016-00005) Funder: GINOP, (TK2016-78), (TKCS-2021/32), (135784) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2023.04.14. 10:15 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 13 August 2023 Correspondence Address: Adany, R.; ELKH-DE Public Health Research Group, Hungary; email: adany.roza@med.unideb.hu Chemicals/CAS: glucose, 50-99-7, 84778-64-3, 8027-56-3; lipid, 66455-18-3; mitogen activated protein kinase, 142243-02-5; triacylglycerol lipase, 9001-62-1</pre> </div></div>