https://m2.mtmt.hu/ hun 2026-04-16 06:00 JournalArticle 33683743 APPROVED true Cited By :1 Export Date: 31 October 2023 Correspondence Address: Romero, R.; Pregnancy Research Branch, United States; email: prbchiefstaff@med.wayne.edu Correspondence Address: Tarca, A.L.; Pregnancy Research Branch, United States; email: atarca@med.wayne.edu 0 false 2026-01-01T16:24:18.102+0000 2025-02-26T14:15:57.786+0000 2023-03-06T11:55:09.432+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-06-26T10:20:56.377+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:41:02.153+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bhatti, G. The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 13 1 3136 3136 16 2023 The intra-uterine components of labor, namely, myometrial contractility, cervical ripening, and decidua/membrane activation, have been extensively characterized and involve a local pro-inflammatory milieu of cellular and soluble immune mediators. Targeted profiling has demonstrated that such processes extend to the intra-amniotic space, yet unbiased analyses of the proteome of human amniotic fluid during labor are lacking. Herein, we utilized an aptamer-based platform to characterize 1,310 amniotic fluid proteins and found that the proteome undergoes substantial changes with term labor (251 proteins with differential abundance, q < 0.1, and fold change > 1.25). Proteins with increased abundance in labor are enriched for immune and inflammatory processes, consistent with prior reports of labor-associated changes in the intra-uterine space. By integrating the amniotic fluid proteome with previously generated placental-derived single-cell RNA-seq data, we demonstrated the labor-driven upregulation of signatures corresponding to stromal-3 and decidual cells. We also determined that changes in amniotic fluid protein abundance are reflected in the maternal plasma proteome. Collectively, these findings provide novel insights into the amniotic fluid proteome in term labor and support its potential use as a source of biomarkers to distinguish between true and false labor by using maternal blood samples. true 2023 true true true false true false GOLD 2026-01-01 true https://doi.org/10.1038/s41598-023-28157-3 8 0 8 8 0 8 8 7 6 8 8 8 8 8 0 0 8 8 8 8 0 7 7 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 2 2 2 2 2025 0 5 5 5 5 D1 A nemzetközi false false false false 2023-03-05T12:00:28.685+0000 Enzimológiai Intézet (TTK); Lendület Reprodukció Rendszerbiológiája Kutatóc... 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bhatti G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Romero R. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gomez-Lopez N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chaiworapongsa T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011696"><a href="/gui2/?type=authors&mode=browse&sel=10011696" target="_blank">Than N.G. 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