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      <abstractText>Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12–1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16–1.70; p &lt; 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 ± SD: 0.99 vs. oPGSHG: 2.70 ± SD: 1.06; p &lt; 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.</abstractText>
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      <label>Pikó Péter et al. Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 5</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10061786&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10061786&quot; target=&quot;_blank&quot;&gt;Pikó, Péter&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10015227&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10015227&quot; target=&quot;_blank&quot;&gt;Bácsné Bába, Éva&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10038661&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10038661&quot; target=&quot;_blank&quot;&gt;Kósa, Zsigmond&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; 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&lt;img title=&quot;Forrásközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-core-icon.png&quot;&gt; &lt;img title=&quot;Idézőközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-citation-icon.png&quot;&gt; &lt;div class=&quot;autype autype0&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10061786&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10061786&quot; target=&quot;_blank&quot;&gt;Pikó Péter (&lt;span class=&quot;authorship-author-name&quot;&gt;Pikó Péter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Népegészségügy&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Epidemiológiai és Surveillance Központ; &lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/&lt;span title=&quot;Népegészség- és Járványtani Intézet&quot;&gt;NegJtI&lt;/span&gt;/ELKH-DE Népegészségügyi Kutatócsoport&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10015227&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10015227&quot; target=&quot;_blank&quot;&gt;Bácsné Bába Éva (&lt;span class=&quot;authorship-author-name&quot;&gt;Bácsné Bába Éva&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gazdálkodás- és szervezéstudományok&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Gazdaságtudományi Kar&quot;&gt;GTK&lt;/span&gt;/Sportgazdasági és -menedzsment Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10038661&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10038661&quot; target=&quot;_blank&quot;&gt;Kósa Zsigmond (&lt;span class=&quot;authorship-author-name&quot;&gt;Kósa Zsigmond&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; egészségtudomány&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Egészségtudományi Kar&quot;&gt;ETK&lt;/span&gt;/&lt;span title=&quot;Egészségtudományi Intézet&quot;&gt;EgTudInt&lt;/span&gt;/Védőnői Módszertani és Prevenciós Tanszék&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10012757&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10012757&quot; target=&quot;_blank&quot;&gt;Sándor János (&lt;span class=&quot;authorship-author-name&quot;&gt;Sándor János&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Népegészségtan&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Népegészség- és Járványtani Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10053985&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10053985&quot; target=&quot;_blank&quot;&gt;Kovács Nóra (&lt;span class=&quot;authorship-author-name&quot;&gt;Kovács Nóra&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; egészségtudományok&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Népegészség- és Járványtani Intézet; &lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/&lt;span title=&quot;Népegészség- és Járványtani Intézet&quot;&gt;NegJtI&lt;/span&gt;/ELKH-DE Népegészségügyi Kutatócsoport&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10010418&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010418&quot; target=&quot;_blank&quot;&gt;Bács Zoltán (&lt;span class=&quot;authorship-author-name&quot;&gt;Bács Zoltán&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Számvitel&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Gazdaságtudományi Kar&quot;&gt;GTK&lt;/span&gt;/&lt;span title=&quot;Számviteli és Pénzügyi Intézet&quot;&gt;SZamvPuI&lt;/span&gt;/Számviteli Tanszék&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;1131057&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=1131057&quot; target=&quot;_blank&quot;&gt;Ádány Róza ✉ (&lt;span class=&quot;authorship-author-name&quot;&gt;Ádány Róza&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Népegészségügy, genetikai epidemiológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Népegészségtani Intézet; &lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Népegészség- és Járványtani Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Epidemiológiai és Surveillance Központ; &lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/&lt;span title=&quot;Népegészség- és Járványtani Intézet&quot;&gt;NegJtI&lt;/span&gt;/ELKH-DE Népegészségügyi Kutatócsoport&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;33679402&quot; target=&quot;_blank&quot;&gt;Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES&lt;/span&gt; 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