https://m2.mtmt.hu/ hun 2026-09-21 12:37 JournalArticle 33675278 VALIDATED true 0 false 2026-09-21T09:41:51.828+0000 2026-03-25T17:14:44.949+0000 2023-03-01T13:06:29.608+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-03-25T17:16:11.276+0000 2026-03-25T17:16:11.276+0000 2023-03-16T08:34:23.184+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2024-04-11T07:19:53.187+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Butz, Henriett Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour true true /api/journal/10051562 REVIEWED true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 12 5 784 784 25 2023 Background. The dual role of GCs has been observed in breast cancer; however, due to many concomitant factors, GR action in cancer biology is still ambiguous. In this study, we aimed to unravel the context-dependent action of GR in breast cancer. Methods. GR expression was characterized in multiple cohorts: (1) 24,256 breast cancer specimens on the RNA level, 220 samples on the protein level and correlated with clinicopathological data; (2) oestrogen receptor (ER)-positive and -negative cell lines were used to test for the presence of ER and ligand, and the effect of the GRβ isoform following GRα and GRβ overexpression on GR action, by in vitro functional assays. Results. We found that GR expression was higher in ER- breast cancer cells compared to ER+ ones, and GR-transactivated genes were implicated mainly in cell migration. Immunohistochemistry showed mostly cytoplasmic but heterogenous staining irrespective of ER status. GRα increased cell proliferation, viability, and the migration of ER- cells. GRβ had a similar effect on breast cancer cell viability, proliferation, and migration. However, the GRβ isoform had the opposite effect depending on the presence of ER: an increased dead cell ratio was found in ER+ breast cancer cells compared to ER- ones. Interestingly, GRα and GRβ action did not depend on the presence of the ligand, suggesting the role of the "intrinsic", ligand-independent action of GR in breast cancer. Conclusions. Staining differences using different GR antibodies may be the reason behind controversial findings in the literature regarding the expression of GR protein and clinicopathological data. Therefore, caution in the interpretation of immunohistochemistry should be applied. By dissecting the effects of GRα and GRβ, we found that the presence of the GR in the context of ER had a different effect on cancer cell behaviour, but independently of ligand availability. Additionally, GR-transactivated genes are mostly involved in cell migration, which raises GR's importance in disease progression. Funding 2024163 /api/funding/2024163 false true Funding 2024164 /api/funding/2024164 false true Funding 2024165 /api/funding/2024165 false true Funding 2024166 /api/funding/2024166 false true Funding 2024167 /api/funding/2024167 false true Funding 2024168 /api/funding/2024168 false true true INTERNATIONAL 2023 true true true false true false GOLD 2026-09-21 true https://doi.org/10.3390/cells12050784 5 0 5 3 2 5 5 5 5 5 5 3 3 3 2 0 5 3 5 3 0 6 6 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 1 2 1 2025 0 3 2 3 2 Q1 false 10020420,10062288 false false false 2023-03-07T10:47:57.391+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Laboratóriumi Medicina Intézet (SE / AOK / I); MTA-SE Lendület Örökletes Endokrin Daganatok Ku... (SE / AOK / K / IISZBK); MTA-SE Örökletes Daganatok Kutatócsoport (SE / AOK / I / LABMEDINT); Országos Onkológiai Intézet 9 43 5 12 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106889351 /api/authorship/106889351 1 0.083 true false true Author 10020420 /api/author/10020420 Butz Henriett true 10020420 true Butz Henriett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889352 /api/authorship/106889352 2 0.083 false false Author 10063558 /api/author/10063558 Saskői Éva true 10063558 true Saskői Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889353 /api/authorship/106889353 3 0.083333336 false false Author 10071844 /api/author/10071844 Krokker Lilla true true Krokker Lilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 107009715 /api/authorship/107009715 4 0.083 false false false Author 10024264 /api/author/10024264 Vereczki Viktória true 10024264 true Viktória Vereczki true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889355 /api/authorship/106889355 5 0.083333336 false false Author 10020685 /api/author/10020685 Alpár Alán true 10020685 true Alpár Alán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889356 /api/authorship/106889356 6 0.083333336 false false Author 10025130 /api/author/10025130 Likó István true 10025130 true Likó István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889357 /api/authorship/106889357 7 0.083 false false Author 10062288 /api/author/10062288 Tóth Erika true 10062288 true Tóth Erika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889358 /api/authorship/106889358 8 0.083333336 false false Szőcs Erika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889359 /api/authorship/106889359 9 0.083 false false Author 10050407 /api/author/10050407 Cserepes Tamás Mihály true 10050407 true Cserepes Mihály true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889360 /api/authorship/106889360 10 0.083333336 false false Nagy Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889361 /api/authorship/106889361 11 0.083333336 false false Kacskovics Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106889362 /api/authorship/106889362 12 0.083 false true Author 10001006 /api/author/10001006 Patócs Attila Balázs true 10001006 true Patócs Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23232320 /api/publicationidentifier/23232320 PlainSource 6 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<span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz Henriett ✉ (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063558"><a href="/gui2/?type=authors&mode=browse&sel=10063558" target="_blank">Saskői Éva (<span class="authorship-author-name">Saskői Éva</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071844"><a href="/gui2/?type=authors&mode=browse&sel=10071844" target="_blank">Krokker Lilla (<span class="authorship-author-name">Krokker Lilla</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="II. Sz. Belgyógyászati Klinika">IISZBK</span>/MTA-SE Lendület Örökletes Endokrin Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024264"><a href="/gui2/?type=authors&mode=browse&sel=10024264" target="_blank">Viktória Vereczki (<span class="authorship-author-name">Vereczki Viktória</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020685"><a href="/gui2/?type=authors&mode=browse&sel=10020685" target="_blank">Alpár Alán (<span class="authorship-author-name">Alpár Alán</span> <span class="authorAux-mtmt"> Anatómia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025130"><a href="/gui2/?type=authors&mode=browse&sel=10025130" target="_blank">Likó István (<span class="authorship-author-name">Likó István</span> <span class="authorAux-mtmt"> Bioinformatika-Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062288"><a href="/gui2/?type=authors&mode=browse&sel=10062288" target="_blank">Tóth Erika (<span class="authorship-author-name">Tóth Erika</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szőcs Erika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050407"><a href="/gui2/?type=authors&mode=browse&sel=10050407" target="_blank">Cserepes Mihály (<span class="authorship-author-name">Cserepes Tamás Mihály</span> <span class="authorAux-mtmt"> tumorbiológia, molekuláris biológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagy Katalin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kacskovics Imre </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs Attila (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Laboratóriumi Medicina Intézet">LABMEDINT</span>/MTA-SE Örökletes Daganatok Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33675278" target="_blank">Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">5</span> <span class="page"> Paper 784. 25 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells12050784" target="_blank" href="https://doi.org/10.3390/cells12050784"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000947304600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000947304600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149766866" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149766866"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36899920" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36899920&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 3 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33675278&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33675278</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFI FK 135065) Támogató: OTKA, New National Excellence Program of the Ministry of Human Capacities(UNKP-22-5-SE-1), (TKP2021-EGA/TKP2021-NVA/ TKP2021-NKTA), (Bolyai Research Fellowship of the Hungarian Academy of Sciences), National Laboratories Excellence program (under the National Tumor Biology Laboratory Project(NLP-17), Hungarian Thematic Excellence Program((TKP2021-EGA-44)) </div> <div class="lastModified">Utolsó módosítás: 2026.03.25. 18:14 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.11. 09:19 Wolf György (MTMT Központi admin) </div> </div></div>