https://m2.mtmt.hu/ eng 2026-10-25 03:59 JournalArticle 33665804 VALIDATED true Department of Pathology, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary Department of Biostatistics, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary Centre for Bioinformatics, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary Department of Internal Medicine and Oncology, Semmelweis University, Korányi Sándor u. 2/a, Budapest, 1083, Hungary Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, Vienna, 1210, Austria University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, Vienna, 1210, Austria Export Date: 23 April 2023 Correspondence Address: Balka, G.; Department of Pathology, István u. 2, Hungary; email: balka.gyula@univet.hu Chemicals/CAS: azaperone, 1649-18-9; embutramide, 15687-14-6; ketamine, 1867-66-9, 6740-88-1, 81771-21-3 Tradenames: narketan, Vetoquinol, Austria; stresnil, Elanco, Germany Manufacturers: Vetoquinol, Austria; Elanco, Germany 0 false 2026-10-23T08:48:15.895+0000 2023-03-31T07:03:21.356+0000 2023-02-27T09:58:29.077+0000 true 10056781 Bikádi Katalin /api/admin/10056781 Admin true 10056781 2026-07-22T07:11:17.846+0000 2023-03-21T09:29:29.915+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Horváth, Dávid G. Quantitative Analysis of Inflammatory Uterine Lesions of Pregnant Gilts with Digital Image Analysis Following Experimental PRRSV-1 Infection true true /api/journal/10021226 REVIEWED true false 10021226 false 10021226 true 2076-2615 2076-2615 Journal FOREIGN 13 5 830 830 18 2023 Reproductive disorders caused by porcine reproductive and respiratory syndrome virus-1 are not yet fully characterized. We report QuPath-based digital image analysis to count inflammatory cells in 141 routinely, and 35 CD163 immunohistochemically stained endometrial slides of vaccinated or unvaccinated pregnant gilts inoculated with a high or low virulent PRRSV-1 strain. To illustrate the superior statistical feasibility of the numerical data determined by digital cell counting, we defined the association between the number of these cells and endometrial, placental, and fetal features. There was strong concordance between the two manual scorers. Distributions of total cell counts and endometrial and placental qPCR results differed significantly between examiner1’s endometritis grades. Total counts’ distribution differed significantly between groups, except for the two unvaccinated. Higher vasculitis scores were associated with higher endometritis scores, and higher total cell counts were expected with high vasculitis/endometritis scores. Cell number thresholds of endometritis grades were determined. A significant correlation between fetal weights and total counts was shown in unvaccinated groups, and a significant positive correlation was found between these counts and endometrial qPCR results. We revealed significant negative correlations between CD163+ counts and qPCR results of the unvaccinated group infected with the highly virulent strain. Digital image analysis was efficiently applied to assess endometrial inflammation objectively. Funding 2023989 /api/funding/2023989 false true true 2023 true true true false true false GOLD 2026-10-23 true https://doi.org/10.3390/ani13050830 3 0 3 1 2 2 3 3 3 3 3 1 1 1 2 0 3 1 3 1 0 7 7 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 2026 0 2 1 2 1 Q1 false false false false 2023-02-26T13:23:04.764+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Bioinformatikai központ (ÁTE / ÁJI); Biomatematikai és számítástechnikai tanszék (ÁTE / GBI); Fertőző Állatbetegségek, Antimikrobiális Rezisz... 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(<span class="authorship-author-name">Horváth Dávid Géza</span> <span class="authorAux-mtmt"> patológia</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Institute of Animal Sciences and Disease Prevention">IASDP</span>/Department of Pathology; <span title="University of Veterinary Medicine Budapest">UVMB</span>/National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022751"><a href="/gui2/?type=authors&mode=browse&sel=10022751" target="_blank">Abonyi-Tóth Zsolt (<span class="authorship-author-name">Abonyi-Tóth Zsolt</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biomathematics and Informatics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071890"><a href="/gui2/?type=authors&mode=browse&sel=10071890" target="_blank">Papp Márton (<span class="authorship-author-name">Papp Márton</span> <span class="authorAux-mtmt"> Bioinformatika, Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Institute of Animal Sciences and Disease Prevention">IASDP</span>/Bioinformatikai központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023803"><a href="/gui2/?type=authors&mode=browse&sel=10023803" target="_blank">Szász Attila Marcell (<span class="authorship-author-name">Szász Attila Marcell</span> <span class="authorAux-mtmt"> emlőpatologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rümenapf Till </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Knecht Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kreutzmann Heinrich </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ladinig Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023087"><a href="/gui2/?type=authors&mode=browse&sel=10023087" target="_blank">Balka Gyula ✉ (<span class="authorship-author-name">Balka Gyula</span> <span class="authorAux-mtmt"> Állatorvosi kórbonctan</span>) </a> </span> <span class="author-affil"><span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Institute of Animal Sciences and Disease Prevention">IASDP</span>/Department of Pathology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33665804" target="_blank">Quantitative Analysis of Inflammatory Uterine Lesions of Pregnant Gilts with Digital Image Analysis Following Experimental PRRSV-1 Infection</a></div> <div> <span class="journal-title">ANIMALS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-2615">2076-2615</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-2615">2076-2615</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">5</span> <span class="page"> Paper 830. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ani13050830" target="_blank" href="https://doi.org/10.3390/ani13050830"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000947251200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000947251200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149794706" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149794706"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36899686" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36899686&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Animal Science and Zoology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 1 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33665804&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33665804</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (RRF-2.3.1-21-2022-00001) </div> <div class="lastModified">Last Modified: 2023.03.31. 09:03 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Pathology, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, István u. 2, Budapest, 1078, Hungary Department of Biostatistics, University of Veterinary M...</pre> </div></div>