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      <abstractText>Based on a systematic review and meta-analysis, our study aimed to provide information about the factors that influence the success of tympanic membrane reconstruction.Our systematic search was conducted on November 24, 2021, using the CENTRAL, Embase, and MEDLINE databases. Observational studies with a minimum of 12 months of follow-up on type I tympanoplasty or myringoplasty were included, while non-English articles, patients with cholesteatoma or specific inflammatory diseases, and ossiculoplasty cases were excluded. The protocol was registered on PROSPERO (registration number: CRD42021289240) and PRISMA reporting guideline was used. Risk of bias was evaluated with the QUIPS tool. A random effect model was used in the analyses. Primary outcome was the rate of closed tympanic cavities.After duplicate removal, 9454 articles were found, of which 39 cohort studies were included. Results of four analyses showed significant effects: age (OR: 0.62, CI 0.50; 0.78, p value: 0.0002), size of the perforation (OR: 0.52, CI 0.29; 0.94, p value: 0.033), opposite ear condition (OR: 0.32, CI 0.12; 0.85, p value: 0.028), and the surgeon's experience (OR: 0.42, CI 0.26; 0.67, p value: 0.005), while prior adenoid surgery, smoking, the site of the perforation, and discharge of the ear did not. Four factors: etiology, Eustachian tube function, concomitant allergic rhinitis, and duration of the ear discharge were analyzed qualitatively.The age of the patient, the size of the perforation, the opposite ear status, and the surgeon's experience have a significant effect on the success of tympanic membrane reconstruction. Further comprehensive studies are needed to analyze the interactions between the factors.Not applicable.</abstractText>
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Veterinary Medicine Budapest&quot;&gt;UVMB&lt;/span&gt;/&lt;span title=&quot;Élelmiszerlánc-biztonsági és Járványvédelmi Intézet&quot;&gt;ÉBJI&lt;/span&gt;/&lt;span title=&quot;Institute of Economics and Biostatistics&quot;&gt;IEB&lt;/span&gt;/Department of Biomathematics and Informatics; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Centre for Translational Medicine&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10037621&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10037621&quot; target=&quot;_blank&quot;&gt;Bánvölgyi András
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Bánvölgyi András&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; bőrgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/Department of Dermatology, Dermatooncology and Venerology; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Centre for Translational Medicine&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10001143&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10001143&quot; target=&quot;_blank&quot;&gt;Csupor Dezső
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Csupor Dezső&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Klinikai gyógyszerészet; Fitokémia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Szeged&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Faculty of Pharmacy&quot;&gt;FP&lt;/span&gt;/Department of Clinical Pharmacy; &lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute for Translational Medicine; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Centre for Translational Medicine&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;Hegyi Péter
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Péter&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute for Translational Medicine; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Centre for Translational Medicine; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/Institute of Pancreatic Diseases&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10064479&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10064479&quot; target=&quot;_blank&quot;&gt;Horváth Tamás ✉
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Horváth Tamás&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Fül- orr- gégészet&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Centre for Translational Medicine&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;33662217&quot; target=&quot;_blank&quot;&gt;Factors influencing successful reconstruction of tympanic membrane perforations : a systematic review and meta-analysis&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0937-4477&quot;&gt;0937-4477&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1434-4726&quot;&gt;1434-4726&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;280&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;6&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 2639-2652
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2023)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Language:
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	&lt;span class=&quot;identifiers&quot;&gt;
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							&lt;a style=&quot;color:blue&quot; title=&quot;10.1007/s00405-023-07831-2&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1007/s00405-023-07831-2&quot;&gt;
									DOI
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									WoS
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
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						&lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot;	Green
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							&lt;a style=&quot;color:blue&quot; title=&quot;26998&quot; target=&quot;_blank&quot; href=&quot;http://publicatio.bibl.u-szeged.hu/26998&quot;&gt;
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	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Otorhinolaryngology&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Medicine (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q2&lt;/div&gt;
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	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
		&lt;span title=&quot;&quot; class=&quot;citingPub-count&quot;&gt;Citing papers: 24&lt;/span&gt;
		| Independent citation: 24
		| Self citation: 0
		| Unknown citation: 0
		| Number of citations in WoS: 15 
		|  Number of citations in Scopus:&amp;nbsp;15 
		|  WoS/Scopus assigned:&amp;nbsp;16 
		|  Number of citations with DOI:&amp;nbsp;22 
		
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		&lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;33662217&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt;
			Number of cited publications: 2
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Publication: 33662217&lt;/span&gt;
    | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; 	Validated
  &lt;/span&gt;
        
	
	
Core	 Citing
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Journal Article
			( Survey paper
			
			)
		&lt;/span&gt;
      		| &lt;span class=&quot;pub-category&quot;&gt;Scientific&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;PubMed XML&lt;/span&gt;
&lt;/div&gt;

&lt;div class=&quot;funder&quot;&gt; (Open access funding provided by Semmelweis University)   &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Last Modified: 2024.12.06. 19:03 Róbert Milánkovics (PTE ÁOK admin 4)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Comments&lt;/u&gt;: Export Date: 01 April 2025; CODEN: EAOTE&lt;/pre&gt;
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