https://m2.mtmt.hu/ hun 2026-07-26 10:36 JournalArticle 3365326 VALIDATED true 0 2018-09-27T22:20:08.000+0000 false 3365326 2026-07-05T07:51:13.294+0000 2022-10-12T08:00:48.578+0000 2018-04-30T21:39:01.000+0000 true 10020938 Kaló Zoltán /api/author/10020938 Author true 10020938 2022-12-05T22:53:30.237+0000 2022-12-05T22:53:30.237+0000 2019-10-24T07:57:42.687+0000 true 10028858 Nagy Timea /api/admin/10028858 Admin true 10028858 2022-10-12T08:00:47.662+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Brixner, D An Evidence Framework for Off-Patent Pharmaceutical Review (EFOR) for Health Technology Assessment in Emerging Markets. true true /api/journal/10028933 REVIEWED true false 10028933 false 10028933 true 2212-1099 2212-1102 Journal FOREIGN 16 9 13 9 5 2018 OBJECTIVE: This article introduces an Evidence Framework for Off-Patent Pharmaceutical Review (EFOR), which establishes value-based criteria in a template that manufacturers use to provide evidence showing how their products meet those criteria. Health authorities in emerging markets can then use the evidence presented in the EFOR to evaluate off-patent pharmaceuticals (OPPs) in a consistent, transparent, and evidence-based manner to support policy decisions, including pricing, reimbursement, formulary listing, and drug procurement. METHODS: A literature search found no multi-criteria evidence framework for evaluating OPPs in emerging markets. An International Outcomes Research Board (IORB) of academia and industry experts conducted extensive research, meetings, and workshops to define high-priority criteria to incorporate into an evidence-based health technology assessment (HTA) tool using the multi-criteria decision analysis (MCDA) technique. The resulting framework was further tailored for country-specific needs in workshops in three emerging countries (Kazakhstan, Vietnam, and Indonesia). RESULTS: The IORB defined nine criteria four categories (Product, Manufacturing, Service, and Value Assessment), which OPP manufacturers can use to provide evidence for reimbursement and health policy decision making. Then the IORB developed the EFOR as a base case document, which can be adapted and used as a template by health authorities in emerging countries. CONCLUSIONS: Emerging countries have a significant need for an HTA tool that balances affordability with accurate evidence showing the value differentiation of OPPs. The value attributes in this setting often are different from those in developed markets, which emphasize new products and have high regulation and manufacturing standards. The EFOR is an easy-to-use, adaptable framework that emerging countries can use to increase the consistency, transparency, and effectiveness of drug decision making. The open source EFOR is available as Supplemental Materials. 2018 87002 true true true false false GREEN 2026-07-05 true https://edit.elte.hu/xmlui/handle/10831/66492 17 0 17 10 4 17 14 11 11 12 12 6 6 10 7 0 17 10 17 10 0 4 4 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2018 0 3 1 3 1 2019 0 2 0 2 0 2020 0 2 1 2 1 2021 0 1 1 1 1 2022 0 2 1 2 1 2023 0 3 2 3 2 2024 0 2 2 2 2 2025 0 1 1 1 1 2026 0 1 1 1 1 Q2 C nemzetközi false 10020938 false false false 2019-01-31T22:59:00.000+0000 2018-04-30T21:40:26.000+0000 Egészségpolitikai és Egészség-gazdaságtan Tanszék (ELTE / TATK) 1 8 1 5 0 false Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 10062222 /api/authorship/10062222 1 0.2 true false Brixner D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28190368 true PersonAuthorship 10062223 /api/authorship/10062223 2 0.2 false false Author 10020938 /api/author/10020938 Kaló Zoltán true 10020938 true Kalo Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28190367 true PersonAuthorship 10062224 /api/authorship/10062224 3 0.2 false false Maniadakis N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28190366 true PersonAuthorship 10062225 /api/authorship/10062225 4 0.2 false false Kim K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28190365 true PersonAuthorship 10062226 /api/authorship/10062226 5 0.2 false true Wijaya K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 28190364 true PublicationIdentifier 1293695 /api/publicationidentifier/1293695 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.vhri.2018.01.003 https://doi.org/10.1016/j.vhri.2018.01.003 false 1765159 true PublicationIdentifier 20936796 /api/publicationidentifier/20936796 SwordSource 92 /api/publicationsource/92 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true EDIT EDIT https://edit.elte.hu/xmlui/handle/10831/@@@ true true 92 true GREEN true 66492 https://edit.elte.hu/xmlui/handle/10831/66492 false true PublicationIdentifier 1293694 /api/publicationidentifier/1293694 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85044660700 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85044660700 false 1842385 true PublicationIdentifier 1293696 /api/publicationidentifier/1293696 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 29605800 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29605800&dopt=Abstract false 1765160 true Classification 12125 /api/classification/12125 true true Classification 12215 /api/classification/12215 true true Classification 12776 /api/classification/12776 true true MtaRating 520762 /api/mtarating/520762 RatingType 10012 /api/ratingtype/10012 GMB Institute 19066 /api/institute/19066 0 false true false Gazdaságtudományi Doktori Minősítő Bizottság Committee on Economics true 19066 true true true C nemzetközi true 20762 true SjrRating 10789136 /api/sjrrating/10789136 103 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2001 /api/classificationexternal/2001 true 2001 true Q2 DIRECT true true /api/publication/3365326 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Brixner D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020938"><a href="/gui2/?type=authors&mode=browse&sel=10020938" target="_blank">Kalo Z (<span class="authorship-author-name">Kaló Zoltán</span> <span class="authorAux-mtmt"> Egészség-gazdaságtan</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Társadalomtudományi Kar">TATK</span>/<span title="Közgazdaságtudományi Intézet">Közgazdtud_Int</span>/Egészségpolitikai és Egészség-gazdaságtan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maniadakis N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wijaya K </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3365326" target="_blank">An Evidence Framework for Off-Patent Pharmaceutical Review (EFOR) for Health Technology Assessment in Emerging Markets.</a></div> <div> <span class="journal-title">VALUE IN HEALTH REGIONAL ISSUES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2212-1099">2212-1099</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2212-1102">2212-1102</a>)</span>: <span class="journal-volume">16</span> <span class="page"> pp 9-13 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.vhri.2018.01.003" target="_blank" href="https://doi.org/10.1016/j.vhri.2018.01.003"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="66492" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/66492"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85044660700" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85044660700"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29605800" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29605800&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Economics, Econometrics and Finance (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Health Policy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Gazdaságtudományi Doktori Minősítő Bizottság IXGJO GMB [1901-]&nbsp;&nbsp;&nbsp;C nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 10 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;12 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3365326&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3365326</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3365326</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.10.12. 10:00 Ladányi Gusztáv (MTMT API user, admin) </div> </div></div>