https://m2.mtmt.hu/ hun 2026-05-25 00:41 JournalArticle 33652227 VALIDATED true 0 false 2026-05-22T18:39:40.869+0000 2024-01-10T15:11:34.940+0000 2023-02-22T07:29:35.419+0000 true 10066331 Vida Zsuzsa Ágnes /api/admin/10066331 Admin Vida Zsuzsa Ágnes (DE/ÁOK/ElettI Admin 5, admin) true 2026-03-25T08:08:26.758+0000 2023-12-23T20:56:03.480+0000 true 10036259 Zékány László /api/admin/10036259 Admin Zékány László (DE/TTK/BOI, DE/TTK/FizKemT, DE/TTK/KemI, DE/TTK/KemI/SZAKemT admin 5) true 10036259 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv (MTMT API user, admin) Ladányi Gusztáv true true Admin 10063514 /api/admin/10063514 Mikola Katalin (MTMT 3, admin) Mikola Katalin true 10063514 true 2024-10-17T16:43:16.160+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kacsir, István true true /api/journal/10051491 REVIEWED FRONTIERS IN CHEMISTRY 2296-2646 2296-2646 true false 10051491 false 10051491 true 2296-2646 2296-2646 Journal FOREIGN 11 1086267 1086267 18 2023 The toxicity of and resistance to platinum complexes as cisplatin, oxaliplatin or carboplatin calls for the replacement of these therapeutic agents in clinical settings. We have previously identified a set of half sandwich-type osmium, ruthenium and iridium complexes with bidentate glycosyl heterocyclic ligands exerting specific cytostatic activity on cancer cells but not on non-transformed primary cells. The apolar nature of the complexes, conferred by large, apolar benzoyl protective groups on the hydroxyl groups of the carbohydrate moiety, was the main molecular feature to induce cytostasis. We exchanged the benzoyl protective groups to straight chain alkanoyl groups with varying length (3 to 7 carbon units) that increased the IC 50 value as compared to the benzoyl-protected complexes and rendered the complexes toxic. These results suggest a need for aromatic groups in the molecule. The pyridine moiety of the bidentate ligand was exchanged for a quinoline group to enlarge the apolar surface of the molecule. This modification decreased the IC 50 value of the complexes. The complexes containing [(η 6 - p -cymene)Ru(II)], [(η 6 - p -cymene)Os(II)] or [(η 5 -Cp*)Ir(III)] were biologically active unlike the complex containing [(η 5 -Cp*)Rh(III)]. The complexes with cytostatic activity were active on ovarian cancer (A2780, ID8), pancreatic adenocarcinoma (Capan2), sarcoma (Saos) and lymphoma cell lines (L428), but not on primary dermal fibroblasts and their activity was dependent on reactive oxygen species production. Importantly, these complexes were cytostatic on cisplatin-resistant A2780 ovarian cancer cells with similar IC 50 values as on cisplatin-sensitive A2780 cells. In addition, the quinoline-containing Ru and Os complexes and the short chain alkanoyl-modified complexes (C3 and C4) proved to be bacteriostatic in multiresistant Gram-positive Enterococcus and Staphylococcus aureus isolates. Hereby, we identified a set of complexes with submicromolar to low micromolar inhibitory constants against a wide range of cancer cells, including platinum resistant cells and against multiresistant Gram-positive bacteria. Funding 2024467 /api/funding/2024467 Kapcsolatok a lipid metabolizmus és a DNS repair rendszer között - a stresszválasz és a metaboliz...(K 123975) Támogató: NKFIH false true Funding 2024468 /api/funding/2024468 C-Glikopiranozil-heterociklusok új típusai és új biológiai alkalmazásai(FK 125067) Támogató: NKFIH false true Funding 2024469 /api/funding/2024469 Big Data, Biotechnológia, Energetika, Terápiás célú fejlesztés, Vízzel kapcsolatos kutatások és a...(TKP2020-IKA-04) Támogató: ITM false true Funding 2024470 /api/funding/2024470 (TKP2021-EGA-19) Támogató: NKFIH false true Funding 2024471 /api/funding/2024471 (TKP2021-EGA-20) Támogató: NKFIH false true true true 2023 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3389/fchem.2023.1086267 14 0 14 6 6 14 14 14 13 14 14 6 6 6 8 0 14 6 14 6 0 14 14 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 2 3 2 2024 0 4 2 4 2 2025 0 7 2 7 2 Q1 false 10037471 false false false 2023-03-19T07:55:37.329+0000 ELKH-DE Sejtbiológiai és Jelátviteli Kutatócsoport (DE / ÁOK); Kémiai Tudományok Doktori Iskola (DE / TMTDT); MTA-DE Lendület Sejtmetabolizmus Kutatócsoport (DE / ÁOK); Metagenomikai Intézet (DE); Molekuláris Medicina Kutató Központ (DE / ÁOK); Népegészség- és Járványtani Intézet (DE / ÁOK); Orvosi Vegytani Intézet (DE / ÁOK); Szerves Kémiai Tanszék (DE / TTK / KemI); Szervetlen és Analitikai Kémiai Tanszék (DE / TTK / KemI) 10 44 9 11 0 true 10063514 10067876 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 106776967 /api/authorship/106776967 Kacsir, István [Kacsir, István (szénhidrát- és ko...), szerző] Szerves Kémiai Tanszék (DE / TTK / KemI); Kémiai Tudományok Doktori Iskola (DE / TMTDT) 1 0.09090909 true false false Author 10093384 /api/author/10093384 Kacsir István (szénhidrát- és komplexkémia) Kacsir István true true Kacsir István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643617 /api/authorship/106643617 Sipos, Adrienn* [Sipos, Adrienn (jelátvitel), szerző] Orvosi Vegytani Intézet (DE / ÁOK) 2 0.091 true false false Author 10037471 /api/author/10037471 Sipos Adrienn (jelátvitel) Sipos Adrienn true 10037471 true Sipos Adrienn true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643618 /api/authorship/106643618 Kiss, Tímea [Kiss, Tímea (molekuláris bioló...), szerző] Népegészség- és Járványtani Intézet (DE / ÁOK) 3 0.091 false false false Author 10048422 /api/author/10048422 Kiss Tímea (molekuláris biológia, genetika) Kiss Tímea true 10048422 true Kiss Tímea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643619 /api/authorship/106643619 Major, Evelin [Major, Evelin (molekuláris biológia), szerző] Orvosi Vegytani Intézet (DE / ÁOK) 4 0.091 false false false Author 10073315 /api/author/10073315 Major Evelin (molekuláris biológia) Major Evelin true true Major Evelin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106776971 /api/authorship/106776971 Bajusz, Nikolett 5 0.091 false false false Bajusz Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643621 /api/authorship/106643621 Tóth, Emese [Tóth, Emese (molekuláris biológia), szerző] Orvosi Vegytani Intézet (DE / ÁOK) 6 0.091 false false false Author 10047768 /api/author/10047768 Tóth Emese (molekuláris biológia) Tóth Emese true 10047768 true Tóth Emese true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643622 /api/authorship/106643622 Buglyó, Péter [Buglyó, Péter (Biokoordinációs k...), szerző] Szervetlen és Analitikai Kémiai Tanszék (DE / TTK / KemI) 7 0.091 false false false Author 10010536 /api/author/10010536 Buglyó Péter (Biokoordinációs kémia) Buglyó Péter true 10010536 true Buglyó Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643623 /api/authorship/106643623 Somsák, László [Somsák, László (Szerves kémia, sz...), szerző] Szerves Kémiai Tanszék (DE / TTK / KemI) 8 0.091 false false false Author 10004159 /api/author/10004159 Somsák László (Szerves kémia, szénhidrátkémia) Somsák László true 10004159 true Somsák László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643624 /api/authorship/106643624 Kardos, Gábor [Kardos, Gábor (klinikai mikrobio...), szerző] Metagenomikai Intézet (DE) 9 0.091 false false false Author 10036771 /api/author/10036771 Kardos Gábor (klinikai mikrobiológia) Kardos Gábor true 10036771 true Kardos Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643625 /api/authorship/106643625 Bai, Péter ✉ [Bay, Péter (Biokémia), szerző] Orvosi Vegytani Intézet (DE / ÁOK); Molekuláris Medicina Kutató Központ (DE / ÁOK); MTA-DE Lendület Sejtmetabolizmus Kutatócsoport (DE / ÁOK); ELKH-DE Sejtbiológiai és Jelátviteli Kutatócsoport (DE / ÁOK) 10 0.091 false false true Author 10000080 /api/author/10000080 Bay Péter (Biokémia) Bay Péter true 10000080 true Bai Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106643626 /api/authorship/106643626 Bokor, Éva ✉ [Bokor, Éva (Szénhidrát kémia), szerző] Szerves Kémiai Tanszék (DE / TTK / KemI) 11 0.091 false true true Author 10021977 /api/author/10021977 Bokor Éva (Szénhidrát kémia) Bokor Éva true 10021977 true Bokor Éva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23106031 /api/publicationidentifier/23106031 DOI: 10.3389/fchem.2023.1086267 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fchem.2023.1086267 https://doi.org/10.3389/fchem.2023.1086267 false true PublicationIdentifier 23254938 /api/publicationidentifier/23254938 WoS: 000932979600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000932979600001 https://www.webofscience.com/wos/woscc/full-record/000932979600001 false true PublicationIdentifier 23106032 /api/publicationidentifier/23106032 Scopus: 85147979908 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85147979908 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85147979908 false true PublicationIdentifier 23106049 /api/publicationidentifier/23106049 PubMed: 36793764 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36793764 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36793764&dopt=Abstract false true PublicationIdentifier 23044727 /api/publicationidentifier/23044727 Egyéb URL: https://www.frontiersin.org/articles/10.3389/fchem.2023.1086267/full PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.frontiersin.org/articles/10.3389/fchem.2023.1086267/full https://www.frontiersin.org/articles/10.3389/fchem.2023.1086267/full false true PublicationIdentifier 25138051 /api/publicationidentifier/25138051 SciFinder: 2023:481480 PlainSource 24 /api/publicationsource/24 SciFinder PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true SciFinder https://scifinder.cas.org/scifinder/view/link_v1/answerset.jsf?l=@@@ true true 24 true IDENTICAL 2023:481480 https://scifinder.cas.org/scifinder/view/link_v1/answerset.jsf?l=2023:481480 true true Classification 10293 /api/classification/10293 Kémiai tudományok true true Keyword 16801 /api/keyword/16801 SARCOMA true 16801 true Keyword 1060770 /api/keyword/1060770 Ovarian cancer true 1060770 true Keyword 1071365 /api/keyword/1071365 VRE true 1071365 true Keyword 1072043 /api/keyword/1072043 MRSA true 1072043 true Keyword 1155093 /api/keyword/1155093 QUINOLINE true 1155093 true Keyword 1585269 /api/keyword/1585269 reactive oxygen species production true true Keyword 2364308 /api/keyword/2364308 Half-sandwich complex true true Keyword 2976265 /api/keyword/2976265 glycosyl triazole true true SjrRating 11362308 /api/sjrrating/11362308 sjr:Q1 (2023) Scopus - Chemistry (miscellaneous) FRONTIERS IN CHEMISTRY 2296-2646 2296-2646 109 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1601 /api/classificationexternal/1601 Scopus - Chemistry (miscellaneous) true 1601 true Q1 DIRECT true true Reference 38591454 /api/reference/38591454 1. Ayala, A., Muñoz, M. F., and Argüelles, S. (2014). Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid. Med. Cell Longev. 2014, 1–31. doi:10.1155/2014/360438. 1 false true Reference 38591455 /api/reference/38591455 2. Bai, P., Bakondi, E., Szabó, E., Gergely, P., Szabó, C., and Virág, L. (2001). Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes. Free Radic. Biol. Med. 31, 1616–1623. doi:10.1016/s0891-5849(01)00756-0. 2 false true Reference 38591456 /api/reference/38591456 3. Bakewell, S., Conde, I., Fallah, Y., McCoy, M., Jin, L., and Shajahan-Haq, A. N. (2020). Inhibition of DNA repair pathways and induction of ROS are potential mechanisms of action of the small molecule inhibitor BOLD-100 in breast cancer. Cancers (Basel) 12, 2647. doi:10.3390/cancers12092647. 3 false true Reference 38591457 /api/reference/38591457 4. Bakondi, E., Gönczi, M., Szabó, E., Bai, P., Pacher, P., Gergely, P., et al. (2003). Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121, 88–95. doi:10.1046/j.1523-1747.2003.12329.x. 4 false true Reference 38591458 /api/reference/38591458 5. Balázs, B., Tóth, Z., Kacsir, I., Sipos, A., Buglyó, P., Somsák, L., et al. (2022). Targeting multiresistant Gram-positive bacteria by ruthenium, osmium, iridium and rhodium half-sandwich type complexes with bidentate monosaccharide ligands. Front. Chem. 10, 868234. doi:10.3389/fchem.2022.868234. 5 false true Reference 38591459 /api/reference/38591459 6. Berger, I., Hanif, M., Nazarov, A. A., Hartinger, C. G., John, R. O., Kuznetsov, M. L., et al. (2008). In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chemistry—A Eur. J. 14, 9046–9057. doi:10.1002/chem.200801032. 6 false true Reference 38591460 /api/reference/38591460 7. Bononi, G., Iacopini, D., Cicio, G., Di Pietro, S., Granchi, C., Di Bussolo, V., et al. (2020). Glycoconjugated metal complexes as cancer diagnostic and therapeutic agents. Chemmedchem 16, 30–64. doi:10.1002/cmdc.202000456. 7 false true Reference 38591461 /api/reference/38591461 8. Box, G. E. P., and Cox, D. R. (1964). An analysis of transformations. J. R. Stat. Soc. B 26, 211–243. doi:10.1111/j.2517-6161.1964.tb00553.x. 8 false true Reference 38591462 /api/reference/38591462 9. Brown, A., Kumar, S., and Tchounwou, P. B. (2019). Cisplatin-based chemotherapy of human cancers. J. Cancer Sci. Ther. 11, 97. 9 false true Reference 38591463 /api/reference/38591463 10. Burris, H. A., Bakewell, S., Bendell, J. C., Infante, J., Jones, S. F., Spigel, D. R., et al. (2016). Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort. ESMO Open 1, e000154. doi:10.1136/esmoopen-2016-000154. 10 false true Reference 38591464 /api/reference/38591464 11. De Camargo, M. S., De Grandis, R. A., Da Silva, M. M., Da Silva, P. B., Santoni, M. M., Eismann, C. E., et al. (2019). Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors. Biometals 32, 89–100. doi:10.1007/s10534-018-0160-0. 11 false true Reference 38591465 /api/reference/38591465 12. EUCAST (2021). MIC determination of non-fastidious and fastidious organisms. [Online]. Available at: https://www.eucast.org/ast_of_bacteria/mic_determination/?no_cache=1 (Accessed 11 04, 2021. 12 false true Reference 38591466 /api/reference/38591466 13. Fernandes, A. C. (2019). Synthesis, biological activity and medicinal applications of ruthenium complexes containing carbohydrate ligands. Curr. Med. Chem. 26, 6412–6437. doi:10.2174/0929867326666190124124350. 13 false true Reference 38591467 /api/reference/38591467 14. Fetoni, A. R., Paciello, F., Mezzogori, D., Rolesi, R., Eramo, S. L., Paludetti, G., et al. (2015). Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and nrf-2 signalling. Br. J. Cancer 113, 1434–1444. doi:10.1038/bjc.2015.359. 14 false true Reference 38591468 /api/reference/38591468 15. Florindo, P., Marques, I. J., Nunes, C. D., and Fernandes, A. C. (2014). Synthesis, characterization and cytotoxicity of cyclopentadienyl ruthenium(II) complexes containing carbohydrate-derived ligands. J. Organomet. Chem. 760, 240–247. doi:10.1016/j.jorganchem.2013.09.004. 15 false true Reference 38591469 /api/reference/38591469 16. Florindo, P. R., Pereira, D. M., Borralho, P. M., Rodrigues, C. M. P., Piedade, M. F. M., and Fernandes, A. C. (2015). Cyclopentadienyl-Ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents. J. Med. Chem. 58, 4339–4347. doi:10.1021/acs.jmedchem.5b00403. 16 false true Reference 38591470 /api/reference/38591470 17. Florindo, P. R., Pereira, D. M., Borralho, P. M., Costa, P. J., Piedade, M. F. M., Rodrigues, C. M. P., et al. (2016). New [(η5-C5H5)Ru(N–N)(PPh3)] [PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Trans. 45, 11926–11930. doi:10.1039/c6dt01571a. 17 false true Reference 38591471 /api/reference/38591471 18. Frei, A., Ramu, S., Lowe, G. J., Dinh, H., Semenec, L., Elliott, A. G., et al. (2021). Platinum cyclooctadiene complexes with activity against gram-positive bacteria. ChemMedChem 16, 3165–3171. doi:10.1002/cmdc.202100157. 18 false true Reference 38591472 /api/reference/38591472 19. Gano, L., Pinheiro, T., Matos, A. P., Tortosa, F., Jorge, T. F., Gonçalves, M. S., et al. (2019). Antitumour and toxicity evaluation of a Ru(II)-Cyclopentadienyl complex in a prostate cancer model by imaging tools. Anti-Cancer Agents Med. Chem. 19, 1262–1275. doi:10.2174/1871520619666190318152726. 19 false true Reference 38591473 /api/reference/38591473 20. Gesztelyi, R., Zsuga, J., Kemény-Beke, A., Varga, B., Juhász, B., and Tósaki, A. (2012). The Hill equation and the origin of quantitative pharmacology. Archive Hist. Exact Sci. 66, 427–438. doi:10.1007/s00407-012-0098-5. 20 false true Reference 38591474 /api/reference/38591474 21. Gichumbi, J. M., and Friedrich, H. B. (2018). Half-sandwich complexes of platinum group metals (Ir, Rh, Ru and Os) and some recent biological and catalytic applications. J. Organomet. Chem. 866, 123–143. doi:10.1016/j.jorganchem.2018.04.021. 21 false true Reference 38591475 /api/reference/38591475 22. Godó, A. J., Bényei, A. C., Duff, B., Egan, D. A., and Buglyó, P. (2012). Synthesis and X-ray diffraction structures of novel half-sandwich Os(II)-and Ru(II)-hydroxamate complexes. RSC Adv. 2, 1486–1495. doi:10.1039/c1ra00998b. 22 false true Reference 38591476 /api/reference/38591476 23. Hamala, V., Martišová, A., Červenková Šťastná, L., Karban, J., Dančo, A., Šimarek, A., et al. (2020). Ruthenium tetrazene complexes bearing glucose moieties on their periphery: Synthesis, characterization, and in vitro cytotoxicity. Appl. Organomet. Chem. 34, e5896. doi:10.1002/aoc.5896. 23 false true Reference 38591477 /api/reference/38591477 24. Hanif, M., Meier, S., Nazarov, A., Risse, J., Legin, A., Casini, A., et al. (2013). Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. Front. Chem. 1, 27. doi:10.3389/fchem.2013.00027. 24 false true Reference 38591478 /api/reference/38591478 25. Hanif, M., Babak, M. V., and Hartinger, C. G. (2014). Development of anticancer agents: wizardry with osmium. Drug Discov. Today 19, 1640–1648. doi:10.1016/j.drudis.2014.06.016. 25 false true Reference 38591479 /api/reference/38591479 26. Hartinger, C. G., Nazarov, A. A., Ashraf, S. M., Dyson, P. J., and Keppler, B. K. (2008). Carbohydrate-metal complexes and their potential as anticancer agents. Curr. Med. Chem. 15, 2574–2591. doi:10.2174/092986708785908978. 26 false true Reference 38591480 /api/reference/38591480 27. Hartinger, C. G., Phillips, A. D., and Nazarov, A. A. (2011). Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics. Curr. Top. Med. Chem. 11, 2688–2702. doi:10.2174/156802611798040769. 27 false true Reference 38591481 /api/reference/38591481 28. Henslee, E. A., Torcal Serrano, R. M., Labeed, F. H., Jabr, R. I., Fry, C. H., Hughes, M. P., et al. (2016). Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach. Analyst 141, 6408–6415. doi:10.1039/c6an01596d. 28 false true Reference 38591482 /api/reference/38591482 29. Hildebrandt, J., Häfner, N., Kritsch, D., Görls, H., Dürst, M., Runnebaum, I. B., et al. (2022). Highly cytotoxic osmium(II) compounds and their ruthenium(II) analogues targeting ovarian carcinoma cell lines and evading cisplatin resistance mechanisms. Int. J. Mol. Sci. 23, 4976. doi:10.3390/ijms23094976. 29 false true Reference 38591483 /api/reference/38591483 30. Holzer, I., Desiatkina, O., Anghel, N., Johns, S. K., Boubaker, G., Hemphill, A., et al. (2022). Trithiolato-bridged dinuclear arene ruthenium(ll)- glycoconjugates: Synthesis and antiparasitic activity. Cambridge: Cambridge Open Engage. ChemRxiv. 30 false true Reference 38591484 /api/reference/38591484 31. Hummell, N. A., and Kirienko, N. V. (2020). Repurposing bioactive compounds for treating multidrug-resistant pathogens. J. Med. Microbiol. 69, 881–894. doi:10.1099/jmm.0.001172. 31 false true Reference 38591485 /api/reference/38591485 32. Iacopini, D., Vančo, J., Di Pietro, S., Bordoni, V., Zacchini, S., Marchetti, F., et al. (2022). New glycoconjugation strategies for ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity. Bioorg. Chem. 126, 105901. doi:10.1016/j.bioorg.2022.105901. 32 false true Reference 38591486 /api/reference/38591486 33. Kacsir, I., Sipos, A., Ujlaki, G., Buglyó, P., Somsák, L., Bai, P., et al. (2021). Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species production. Int. J. Mol. Sci. 22, 10454. doi:10.3390/ijms221910454. 33 false true Reference 38591487 /api/reference/38591487 34. Kacsir, I., Sipos, A., Bényei, A., Janka, E., Buglyó, P., Somsák, L., et al. (2022). Reactive oxygen species production is responsible for antineoplastic activity of osmium, ruthenium, iridium and rhodium half-sandwich type complexes with bidentate glycosyl hetero-cyclic ligands in various cancer cell models. Int. J. Mol. Sci. 23, 813. doi:10.3390/ijms23020813. 34 false true Reference 38591488 /api/reference/38591488 35. Kenny, R. G., and Marmion, C. J. (2019). Toward multi-targeted platinum and ruthenium drugs-A new paradigm in cancer drug treatment regimens? Chem. Rev. 119, 1058–1137. doi:10.1021/acs.chemrev.8b00271. 35 false true Reference 38591489 /api/reference/38591489 36. Konkankit, C. C., Marker, S. C., Knopf, K. M., and Wilson, J. J. (2018). Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium. Dalton Trans. 47, 9934–9974. doi:10.1039/c8dt01858h. 36 false true Reference 38591490 /api/reference/38591490 37. Kovács, P., Csonka, T., Kovács, T., Sári, Z., Ujlaki, G., Sipos, A., et al. (2019). Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer. Cancers (Basel) 11, 1255. doi:10.3390/cancers11091255. 37 false true Reference 38591517 /api/reference/38591517 38. Štarha, P., and Trávníček, Z. (2019). Non-platinum complexes containing releasable biologically active ligands. Coord. Chem. Rev. 395, 130–145. doi:10.1016/j.ccr.2019.06.001. 38 false true Reference 38591491 /api/reference/38591491 39. Kulkarni, G. S., Lilge, L., Nesbitt, M., Dumoulin-White, R. J., Mandel, A., and Jewett, M. a. S. (2022). A phase 1b clinical study of intravesical photodynamic therapy in patients with Bacillus calmette-guérin-unresponsive non-muscle-invasive bladder cancer. Eur. Urol. Open Sci. 41, 105–111. doi:10.1016/j.euros.2022.04.015. 39 false true Reference 38591492 /api/reference/38591492 40. Leijen, S., Burgers, S. A., Baas, P., Pluim, D., Tibben, M., Van Werkhoven, E., et al. (2015). Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy. Investig. New Drugs 33, 201–214. doi:10.1007/s10637-014-0179-1. 40 false true Reference 38591493 /api/reference/38591493 41. Leung, C. H., Zhong, H. J., Chan, D. S. H., and Ma, D. L. (2013). Bioactive iridium and rhodium complexes as therapeutic agents. Coord. Chem. Rev. 257, 1764–1776. doi:10.1016/j.ccr.2013.01.034. 41 false true Reference 38591494 /api/reference/38591494 42. Li, G., Liu, H., Feng, R., Kang, T. S., Wang, W., Ko, C. N., et al. (2021). A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury. Redox Biol. 48, 102129. doi:10.1016/j.redox.2021.102129. 42 false true Reference 38591495 /api/reference/38591495 43. Li, Y., Liu, B., Shi, H., Wang, Y., Sun, Q., and Zhang, Q. (2021). Metal complexes against breast cancer stem cells. Dalton Trans. 50, 14498–14512. doi:10.1039/d1dt02909f. 43 false true Reference 38591496 /api/reference/38591496 44. Liu, Z., and Sadler, P. J. (2014). Organoiridium complexes: anticancer agents and catalysts. Accounts Chem. Res. 47, 1174–1185. doi:10.1021/ar400266c. 44 false true Reference 38591497 /api/reference/38591497 45. Liu, J., Lai, H., Xiong, Z., Chen, B., and Chen, T. (2019). Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy. Chem. Commun. 55, 9904–9914. doi:10.1039/c9cc04098f. 45 false true Reference 38591498 /api/reference/38591498 46. Lund, R. J., Huhtinen, K., Salmi, J., Rantala, J., Nguyen, E. V., Moulder, R., et al. (2017). DNA methylation and transcriptome changes associated with cisplatin resistance in ovarian cancer. Sci. Rep. 7, 1469. doi:10.1038/s41598-017-01624-4. 46 false true Reference 38591499 /api/reference/38591499 47. Máliková, K., Masaryk, L., and Štarha, P. (2021). Anticancer half-sandwich rhodium(III) complexes. Inorganics 9, 26. doi:10.3390/inorganics9040026. 47 false true Reference 38591500 /api/reference/38591500 48. Mansour, A. M. (2021). Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans. RSC Adv. 11, 39748–39757. doi:10.1039/d1ra06559a. 48 false true Reference 38591501 /api/reference/38591501 49. Márton, J., Fodor, T., Nagy, L., Vida, A., Kis, G., Brunyánszki, A., et al. (2018). PARP10 (ARTD10) modulates mitochondrial function. PLoS One 13, e0187789. doi:10.1371/journal.pone.0187789. 49 false true Reference 38591502 /api/reference/38591502 50. Mccarron, A. J., Armstrong, C., Glynn, G., Millar, B. C., Rooney, P. J., Goldsmith, C. E., et al. (2012). Antibacterial effects on acinetobacter species of commonly employed antineoplastic agents used in the treatment of haematological malignancies: an in vitro laboratory evaluation. Br. J. Biomed. Sci. 69, 14–17. doi:10.1080/09674845.2012.11669916. 50 false true Reference 38591503 /api/reference/38591503 51. Mcmullen, M., Madariaga, A., and Lheureux, S. (2020). New approaches for targeting platinum-resistant ovarian cancer. Semin. Cancer Biol. 77, 167–181. doi:10.1016/j.semcancer.2020.08.013. 51 false true Reference 38591516 /api/reference/38591516 52. Smolková, K., Mikó, E., Kovács, T., Leguina-Ruzzi, A., Sipos, A., and Bai, P. (2020). Nuclear factor erythroid 2-related factor 2 in regulating cancer metabolism. Antioxid. Redox Signal. 33, 966–997. doi:10.1089/ars.2020.8024. 52 false true Reference 38591504 /api/reference/38591504 53. Meier-Menches, S. M., Gerner, C., Berger, W., Hartinger, C. G., and Keppler, B. K. (2018). Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development. Chem. Soc. Rev. 47, 909–928. doi:10.1039/c7cs00332c. 53 false true Reference 38591505 /api/reference/38591505 54. MelChart, M., and Sadler, P. J. (2005). “Ruthenium arene anticancer complexes,” in Bioorganometallics, 39–64. 54 false true Reference 38591506 /api/reference/38591506 55. Mello-Andrade, F., Cardoso, C. G., Silva, C. R. E., Chen-Chen, L., Melo-Reis, P. R., Lima, A. P., et al. (2018). Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos. Biomed. Pharmacother. 107, 1082–1092. doi:10.1016/j.biopha.2018.08.051. 55 false true Reference 38591507 /api/reference/38591507 56. Mihajlovic, K., Milosavljevic, I., Jeremic, J., Savic, M., Sretenovic, J., Srejovic, I. M., et al. (2020). Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart. Can. J. Physiology Pharmacol. 99, 207–217. doi:10.1139/cjpp-2020-0349. 56 false true Reference 38591508 /api/reference/38591508 57. Mukherjea, D., Dhukhwa, A., Sapra, A., Bhandari, P., Woolford, K., Franke, J., et al. (2020). Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity. Expert Opin. Drug Metab. Toxicol. 16, 965–982. doi:10.1080/17425255.2020.1806235. 57 false true Reference 38591509 /api/reference/38591509 58. Nabiyeva, T., Marschner, C., and Blom, B. (2020). Synthesis, structure and anti-cancer activity of osmium complexes bearing pi-bound arene substituents and phosphane Co-ligands: A review. Eur. J. Med. Chem. 201, 112483. doi:10.1016/j.ejmech.2020.112483. 58 false true Reference 38591510 /api/reference/38591510 59. Parveen, S., Hanif, M., Leung, E., Tong, K. K. H., Yang, A., Astin, J., et al. (2019). Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity. Chem. Commun. 55, 12016–12019. doi:10.1039/c9cc03822a. 59 false true Reference 38591511 /api/reference/38591511 60. Quirante, J., Ruiz, D., Gonzalez, A., López, C., Cascante, M., Cortés, R., et al. (2011). Platinum(II) and palladium(II) complexes with (N, N') and (C, N, N')- ligands derived from pyrazole as anticancer and antimalarial agents: synthesis, characterization and in vitro activities. J. Inorg. Biochem. 105, 1720–1728. doi:10.1016/j.jinorgbio.2011.09.021. 60 false true Reference 38591512 /api/reference/38591512 61. Sári, Z., Mikó, E., Kovács, T., Boratkó, A., Ujlaki, G., Jankó, L., et al. (2020a). Indoxylsulfate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors and induction of oxidative stress. Cancers (Basel) 12, 2915. doi:10.3390/cancers12102915. 61 false true Reference 38591513 /api/reference/38591513 62. Sári, Z., Mikó, E., Kovács, T., Jankó, L., Csonka, T., Sebő, E., et al. (2020b). Indolepropionic acid, a metabolite of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress. Cancers (Basel) 12, 2411. doi:10.3390/cancers12092411. 62 false true Reference 38591514 /api/reference/38591514 63. Sipos, A., Ujlaki, G., Mikó, E., Maka, E., Szabó, J., Uray, K., et al. (2021). The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling. Mol. Med. 27, 33. doi:10.1186/s10020-021-00295-2. 63 false true Reference 38591515 /api/reference/38591515 64. Skehan, P., Storeng, R., Scudiero, D., Monks, A., Mcmahon, J., Vistica, D., et al. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82, 1107–1112. doi:10.1093/jnci/82.13.1107. 64 false true Reference 38591518 /api/reference/38591518 65. Vieites, M., Smircich, P., Pagano, M., Otero, L., Fischer, F. L., Terenzi, H., et al. (2011). DNA as molecular target of analogous palladium and platinum anti-trypanosoma cruzi compounds: a comparative study. J. Inorg. Biochem. 105, 1704–1711. doi:10.1016/j.jinorgbio.2011.07.018. 65 false true Reference 38591519 /api/reference/38591519 66. Virág, L., Salzman, A. L., and Szabó, C. (1998). Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J. Immunol. 161, 3753–3759. doi:10.4049/jimmunol.161.7.3753. 66 false true Reference 38591520 /api/reference/38591520 67. Xu, Z., Kong, D., He, X., Guo, L., Ge, X., Liu, X., et al. (2018). Mitochondria-targeted half-sandwich rutheniumII diimine complexes: anticancer and antimetastasis via ROS-mediated signalling. Inorg. Chem. Front. 5, 2100–2105. doi:10.1039/c8qi00476e. 67 false true Reference 38591521 /api/reference/38591521 68. Yu, C., Wang, Z., Sun, Z., Zhang, L., Zhang, W., Xu, Y., et al. (2020). Platinum-based combination therapy: Molecular rationale, current clinical uses, and future perspectives. J. Med. Chem. 63, 13397–13412. doi:10.1021/acs.jmedchem.0c00950. 68 false true Reference 38591522 /api/reference/38591522 69. Yuan, M., Chua, S. L., Liu, Y., Drautz-Moses, D. I., Yam, J. K. H., Aung, T. T., et al. (2018). Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents. Beilstein J. Org. Chem. 14, 3059–3069. doi:10.3762/bjoc.14.284. 69 false true Reference 38591523 /api/reference/38591523 70. Yufanyi, D. M., Abbo, H. S., Titinchi, S. J. J., and Neville, T. (2020). Platinum(II) and ruthenium(II) complexes in medicine: Antimycobacterial and anti-HIV activities. Coord. Chem. Rev. 414, 213285. doi:10.1016/j.ccr.2020.213285. 70 false true Reference 38591524 /api/reference/38591524 71. Yusoh, N. A., Ahmad, H., and Gill, M. R. (2020). Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy. ChemMedChem 15, 2121–2135. doi:10.1002/cmdc.202000391. 71 false true Reference 38591525 /api/reference/38591525 72. Zeng, L., Gupta, P., Chen, Y., Wang, E., Ji, L., Chao, H., et al. (2017). The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials. Chem. Soc. Rev. 46, 5771–5804. doi:10.1039/c7cs00195a. 72 false true Reference 38591526 /api/reference/38591526 73. Zhang, H., and Forman, H. J. (2017). 4-hydroxynonenal-mediated signaling and aging. Free Radic. Biol. Med. 111, 219–225. doi:10.1016/j.freeradbiomed.2016.11.032. 73 false true Reference 38591527 /api/reference/38591527 74. Zhang, L., Zheng, Y., Callahan, B., Belfort, M., and Liu, Y. (2011). Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria. J. Biol. Chem. 286, 1277–1282. doi:10.1074/jbc.m110.171124 74 false true /api/publication/33652227 Kacsir István et al. Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria. (2023) FRONTIERS IN CHEMISTRY 2296-2646 2296-2646 11<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10093384"><a href="/gui2/?type=authors&mode=browse&sel=10093384" target="_blank">Kacsir István (<span class="authorship-author-name">Kacsir István</span> <span class="authorAux-mtmt"> szénhidrát- és komplexkémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szerves Kémiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi Doktori Tanács">TtDt</span>/Kémiai Tudományok Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037471"><a href="/gui2/?type=authors&mode=browse&sel=10037471" target="_blank">Sipos Adrienn^* (<span class="authorship-author-name">Sipos Adrienn</span> <span class="authorAux-mtmt"> jelátvitel</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048422"><a href="/gui2/?type=authors&mode=browse&sel=10048422" target="_blank">Kiss Tímea (<span class="authorship-author-name">Kiss Tímea</span> <span class="authorAux-mtmt"> molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Népegészség- és Járványtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073315"><a href="/gui2/?type=authors&mode=browse&sel=10073315" target="_blank">Major Evelin (<span class="authorship-author-name">Major Evelin</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bajusz Nikolett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047768"><a href="/gui2/?type=authors&mode=browse&sel=10047768" target="_blank">Tóth Emese (<span class="authorship-author-name">Tóth Emese</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010536"><a href="/gui2/?type=authors&mode=browse&sel=10010536" target="_blank">Buglyó Péter (<span class="authorship-author-name">Buglyó Péter</span> <span class="authorAux-mtmt"> Biokoordinációs kémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szervetlen és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004159"><a href="/gui2/?type=authors&mode=browse&sel=10004159" target="_blank">Somsák László (<span class="authorship-author-name">Somsák László</span> <span class="authorAux-mtmt"> Szerves kémia, szénhidrátkémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szerves Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036771"><a href="/gui2/?type=authors&mode=browse&sel=10036771" target="_blank">Kardos Gábor (<span class="authorship-author-name">Kardos Gábor</span> <span class="authorAux-mtmt"> klinikai mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/Metagenomikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000080"><a href="/gui2/?type=authors&mode=browse&sel=10000080" target="_blank">Bai Péter ✉ (<span class="authorship-author-name">Bay Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Molekuláris Medicina Kutató Központ; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/MTA-DE Lendület Sejtmetabolizmus Kutatócsoport; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/ELKH-DE Sejtbiológiai és Jelátviteli Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021977"><a href="/gui2/?type=authors&mode=browse&sel=10021977" target="_blank">Bokor Éva ✉ (<span class="authorship-author-name">Bokor Éva</span> <span class="authorAux-mtmt"> Szénhidrát kémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szerves Kémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33652227" target="_blank">Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria</a></div> <div> <span class="journal-title">FRONTIERS IN CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-2646">2296-2646</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2296-2646">2296-2646</a>)</span>: <span class="journal-volume">11</span> <span class="page"> Paper 1086267. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fchem.2023.1086267" target="_blank" href="https://doi.org/10.3389/fchem.2023.1086267"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000932979600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000932979600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85147979908" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85147979908"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36793764" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36793764&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.frontiersin.org/articles/10.3389/fchem.2023.1086267/full" target="_blank" href="https://www.frontiersin.org/articles/10.3389/fchem.2023.1086267/full"> Egyéb URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="2023:481480" target="_blank" href="https://scifinder.cas.org/scifinder/view/link_v1/answerset.jsf?l=2023:481480"> SciFinder </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 6 | Függő: 8 | Nem jelölt: 0 | WoS jelölt: 14 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;14 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33652227&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33652227</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Bibtex</span> </div> <div class="funder"> Kapcsolatok a lipid metabolizmus és a DNS repair rendszer között - a stresszválasz és a metaboliz...(K 123975) Támogató: NKFIH, C-Glikopiranozil-heterociklusok új típusai és új biológiai alkalmazásai(FK 125067) Támogató: NKFIH, Big Data, Biotechnológia, Energetika, Terápiás célú fejlesztés, Vízzel kapcsolatos kutatások és a...(TKP2020-IKA-04) Támogató: ITM, (TKP2021-EGA-19) Támogató: NKFIH, (TKP2021-EGA-20) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2024.01.10. 16:11 Zékány László (DE/TTK/BOI, DE/TTK/FizKemT, DE/TTK/KemI, DE/TTK/KemI/SZAKemT admin 5) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:43 Ladányi Gusztáv (MTMT API user, admin) Mikola Katalin (MTMT 3, admin) </div> </div></div>