Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

https://m2.mtmt.hu/ hun 2026-09-23 02:32 JournalArticle 33649151 APPROVED true 0 false 2026-05-22T18:32:42.853+0000 2025-02-26T14:15:38.876+0000 2023-02-20T14:39:06.732+0000 true 10012617 Arányi Tamás /api/author/10012617 Author Arányi Tamás (Génexpresszió szabályozás) true 10012617 2025-02-26T14:15:39.105+0000 2025-02-26T14:15:39.105+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:40:59.043+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Liang, Xiujie Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment true true /api/journal/2227 REVIEWED JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 1046-6673 1533-3450 true false 2227 false 2227 true 1046-6673 1533-3450 Journal FOREIGN 34 4 572 589 572 18 2023 Epigenetic changes have been proposed to mediate nephron endowment during development, a critical determinant of future renal disease development. Hydroxymethyl cytosine, an epigenetic modification important for gene regulation, is abundant in the human kidney, but its physiologic role and the role of DNA demethylase enzymes encoded by the Tet1, Tet2, or Tet3, which mediate cytosine hydroxymethylation, are unclear. By genetically deleting Tet1, Tet2, or Tet3 in nephron progenitors in mice, the authors showed that combined Tet2 and Tet3 loss in nephron progenitors cause defective kidney development, leading to kidney failure and perinatal death. Tet2 and Tet3 deletion also caused an alteration in demethylation and expression of genes critical for nephron formation. These findings establish that Tet2- and Tet3-mediated cytosine hydroxymethylation in nephron progenitors plays a critical role in nephron endowment. true true 2023 true true true false true false NONE 2026-05-22 false 10 0 10 5 1 9 10 9 7 10 10 5 5 5 5 0 10 5 10 5 0 1 1 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 5 3 5 3 2025 0 3 1 3 1 2026 0 2 1 2 1 D1 false 10012617 false false false 2023-04-17T09:01:31.135+0000 Enzimológiai Intézet (TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 12 2 7 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 106763135 /api/authorship/106763135 Liang, Xiujie 1 0.14285715 true false false Liang Xiujie true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763136 /api/authorship/106763136 Aranyi, Tamas [Arányi, Tamás (Génexpresszió sza...), szerző] Enzimológiai Intézet (TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 0.143 false false false Author 10012617 /api/author/10012617 Arányi Tamás (Génexpresszió szabályozás) Arányi Tamás true 10012617 true Aranyi Tamas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763137 /api/authorship/106763137 Zhou, Jianfu 3 0.14285715 false false false Zhou Jianfu true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763138 /api/authorship/106763138 Guan, Yuting 4 0.14285715 false false false Guan Yuting true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763139 /api/authorship/106763139 Hu, Hailong 5 0.14285715 false false false Hu Hailong true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763140 /api/authorship/106763140 Liu, Hongbo 6 0.14285715 false false false Liu Hongbo true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106763141 /api/authorship/106763141 Susztak, Katalin ✉ 7 0.143 false true true Susztak Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23098460 /api/publicationidentifier/23098460 DOI: 10.1681/ASN.2022040460 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1681/ASN.2022040460 https://doi.org/10.1681/ASN.2022040460 false true PublicationIdentifier 24208887 /api/publicationidentifier/24208887 WoS: 001012255600010 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001012255600010 https://www.webofscience.com/wos/woscc/full-record/001012255600010 true true PublicationIdentifier 23387419 /api/publicationidentifier/23387419 Scopus: 85151575184 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85151575184 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151575184 true true PublicationIdentifier 23098483 /api/publicationidentifier/23098483 PubMed: 36522157 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36522157 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36522157&dopt=Abstract false true SjrRating 11397126 /api/sjrrating/11397126 sjr:D1 (2023) Scopus - Medicine (miscellaneous) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 1046-6673 1533-3450 63 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true D1 DIRECT true true Reference 38529719 /api/reference/38529719 1. 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(2023) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 1046-6673 1533-3450 34 4 572-589<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Liang Xiujie </span> ;    <span class="author-name" mtid="10012617"><a href="/gui2/?type=authors&mode=browse&sel=10012617" target="_blank">Aranyi Tamas (<span class="authorship-author-name">Arányi Tamás</span> <span class="authorAux-mtmt"> Génexpresszió szabályozás</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;    <span class="author-name" >Zhou Jianfu </span> ;    <span class="author-name" >Guan Yuting </span> ;    <span class="author-name" >Hu Hailong </span> ;    <span class="author-name" >Liu Hongbo </span> ;    <span class="author-name" >Susztak Katalin ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33649151" target="_blank">Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment</a></div> <div> <span class="journal-title">JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1046-6673">1046-6673</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-3450">1533-3450</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">4</span> <span class="page"> pp 572-589 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1681/ASN.2022040460" target="_blank" href="https://doi.org/10.1681/ASN.2022040460"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001012255600010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001012255600010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85151575184" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85151575184"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36522157" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36522157&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nephrology   SJR indikátor: D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 5 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt: 7 | WoS/Scopus jelölt: 10 | DOI jelölt: 10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33649151&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33649151</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.02.26. 15:15 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.04. 12:40 Vándor Andrea (VA, admin) </div> </div></div>