https://m2.mtmt.hu/ eng 2026-09-22 12:44 JournalArticle 33642580 VALIDATED true 0 false 2026-08-04T08:50:11.659+0000 2024-04-17T14:19:00.357+0000 2023-02-16T07:55:10.073+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-08-26T10:17:48.208+0000 2026-08-26T10:17:48.208+0000 2024-04-17T14:19:00.650+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mut-Arbona, Paula Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development. true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 43 7 1125 1142 1125 18 2023 At high levels, extracellular ATP operates as a “danger” molecule under pathologic conditions through purinergic receptors, including the ionotropic P2X7 receptor (P2X7R). Its endogenous activation is associated with neurodevelopmental disorders; however, its function during early embryonic stages remains largely unclear. Our objective was to determine the role of P2X7R in the regulation of neuronal outgrowth. For this purpose, we performed Sholl analysis of dendritic branches on primary hippocampal neurons and in acute hippocampal slices from WT mice and mice with genetic deficiency or pharmacological blockade of P2X7R. Because abnormal dendritic branching is a hallmark of certain neurodevelopmental disorders, such as schizophrenia, a model of maternal immune activation (MIA)-induced schizophrenia, was used for further morphologic investigations. Subsequently, we studied MIA-induced behavioral deficits in young adult mice females and males. Genetic deficiency or pharmacological blockade of P2X7R led to branching deficits under physiological conditions. Moreover, pathologic activation of the receptor led to deficits in dendritic outgrowth on primary neurons from WT mice but not those from P2X7R KO mice exposed to MIA. Likewise, only MIA-exposed WT mice displayed schizophrenia-like behavioral and cognitive deficits. Therefore, we conclude that P2X7R has different roles in the development of hippocampal dendritic arborization under physiological and pathologic conditions. 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071685"><a href="/gui2/?type=authors&mode=browse&sel=10071685" target="_blank">Mut-Arbona Paula (<span class="authorship-author-name">Mut-Arbona Paula</span> <span class="authorAux-mtmt"> Neuroscience</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070293"><a href="/gui2/?type=authors&mode=browse&sel=10070293" target="_blank">Huang Lumei (<span class="authorship-author-name">Huang Lumei</span> <span class="authorAux-mtmt"> Institute of experimental medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="91"><a href="/gui2/?type=authors&mode=browse&sel=91" target="_blank">Baranyi Mária (<span class="authorship-author-name">Baranyi Mária</span> <span class="authorAux-mtmt"> Molekuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054736"><a href="/gui2/?type=authors&mode=browse&sel=10054736" target="_blank">Tod Pál (<span class="authorship-author-name">Tod Pál</span> <span class="authorAux-mtmt"> Purinerg jelátviteli rendszer a központi idegre...</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032256"><a href="/gui2/?type=authors&mode=browse&sel=10032256" target="_blank">Iring András (<span class="authorship-author-name">Iring András</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Calzaferri Francesco </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >de los Ríos Cristobal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlágh Beáta ✉ (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Pharmacology; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33642580" target="_blank">Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development.</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">43</span> <span class="journal-issue">7</span> <span class="page"> pp 1125-1142 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1523/JNEUROSCI.0805-22.2022" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.0805-22.2022"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000944837500005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000944837500005"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="169950" target="_blank" href="https://real.mtak.hu/169950"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85148307414" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148307414"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36732073" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36732073&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 10 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33642580&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33642580</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO, National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), Hungarian Brain Research Program(NAP2022-I-1/2022), Grant 131629(Hungarian Research and Development Fund), Recovery and Resilience Facility of the European Union within the framework of Program Széchenyi ...(RRF-2.3.1-21-2022-00011), Post-Covid Program of the Hungarian Academy of Sciences(PC-II-2/ 2022), Hungarian Research and Development Fund(131629), (PC-II-2/2022) Funder: Hungarian Academy of Sciences, European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska Curie(766124), Hungarian Academy of Sciences Premium Postdoctoral Research Program(PPD2019-20/2019-439) </div> <div class="lastModified">Last Modified: 2024.04.17. 16:19 Katalin Lévayné 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