https://m2.mtmt.hu/ hun 2026-05-25 03:18 JournalArticle 33635331 VALIDATED true Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, Budapest, H-1094, Hungary Department of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, Budapest, H-1117, Hungary MS Metabolomics Research Group, Centre for Structural Study, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar Tudósok Krt. 2, Budapest, H-1117, Hungary Research Group of Analytical Chemistry, University of Pannonia, Egyetem utca 10, Veszprém, H-8200, Hungary Cited By :2 Export Date: 30 July 2024 Correspondence Address: Csala, M.; Department of Molecular Biology, Tűzoltó u. 37-47, Hungary; email: csala.miklos@med.semmelweis-univ.hu Correspondence Address: Csámpai, A.; Department of Organic Chemistry, Pázmány P. Sétány 1/A, Hungary; email: antal.csampai@ttk.elte.hu 0 false 2026-05-22T18:03:30.413+0000 2024-02-09T19:14:54.424+0000 2023-02-11T21:10:48.135+0000 true 10000786 Csala Miklós /api/author/10000786 Author Csala Miklós (Biokémia) true 10000786 2025-05-06T09:31:57.640+0000 2023-03-07T08:40:35.534+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Murányi, József true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 4 3456 3456 18 2023 In a search for novel therapeutic options for head and neck squamous cell carcinomas (HNSCCs) generally treated with limited therapeutic success, we synthesized a series of novel erlotinib–chalcone molecular hybrids with 1,2,3-triazole and alkyne linkers and evaluated them for their anticancer activity on Fadu, Detroit 562 and SCC-25 HNSCC cell lines. Time- and dose-dependent cell viability measurements disclosed a significantly increased efficiency of the hybrids compared to the 1:1 combination of erlotinib and a reference chalcone. The clonogenic assay demonstrated that hybrids eradicate HNSCC cells in low micromolar concentrations. Experiments focusing on potential molecular targets indicate that the hybrids trigger the anticancer effect by a complementary mechanism of action that is independent of the canonical targets of their molecular fragments. Confocal microscopic imaging and real-time apoptosis/necrosis detection assay pointed to slightly different cell death mechanisms induced by the most prominent triazole- and alkyne-tethered hybrids (6a and 13, respectively). While 6a featured the lowest IC50 values on each of the three HNSCC cell lines, in Detroit 562 cells, this hybrid induced necrosis more markedly compared to 13. The therapeutic potential indicated by the observed anticancer efficacy of our selected hybrid molecules validates the concept of development and justifies further investigation to reveal the underlying mechanism of action. Funding 2024302 /api/funding/2024302 (K-129037) Támogató: OTKA false true Funding 2024303 /api/funding/2024303 (NVKP_16-1-2016-0036) false true Funding 2024304 /api/funding/2024304 (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH false true Funding 2024305 /api/funding/2024305 (K124813) false true Funding 2024306 /api/funding/2024306 (2020-4.1.1.-TKP2020) false true Funding 2024307 /api/funding/2024307 (TKP2021-EGA-24) false true true 2023 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/ijms24043456 5 0 5 5 0 5 5 5 5 5 5 5 5 5 0 0 5 5 5 5 0 4 4 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 false 10093972,10047778,10008627,10000786,10076057 false false false 2023-02-13T06:28:20.285+0000 Hevesy György Kémia Doktori Iskola (ELTE / TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Szerves Kémiai Tanszék (ELTE / TTK / KI); Természettudományi Központ (PE / MK) 9 39 4 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 106707043 /api/authorship/106707043 Murányi, József [Murányi, József (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.111 true false false Author 10047778 /api/author/10047778 Murányi József (Biokémia) Murányi József true 10047778 true Murányi József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707044 /api/authorship/106707044 Duró, Cintia [Jernei-Duró, Cintia (Szerves kémia), szerző] Hevesy György Kémia Doktori Iskola (ELTE / TTK) 2 0.11111111 false false false Author 10093972 /api/author/10093972 Jernei-Duró Cintia (Szerves kémia) Jernei-Duró Cintia true true Duró Cintia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707045 /api/authorship/106707045 Gurbi, Bianka [Gurbi, Bianka (célzott daganatte...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.111 false false false Author 10059086 /api/author/10059086 Gurbi Bianka (célzott daganatterápia) Gurbi Bianka true 10059086 true Gurbi Bianka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707046 /api/authorship/106707046 Móra, István [Móra , István András (Biomérnök), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.111 false false false Author 10082532 /api/author/10082532 Móra István András (Biomérnök) Móra István András true true Móra István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707047 /api/authorship/106707047 Varga, Attila [Varga, Attila (molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 5 0.111 false false false Author 10040840 /api/author/10040840 Varga Attila (molekuláris biológia) Varga Attila true 10040840 true Varga Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707048 /api/authorship/106707048 Németh, Krisztina [Németh, Krisztina (Tömegspektrometria), szerző] 6 0.11111111 false false false Author 10076057 /api/author/10076057 Németh Krisztina (Tömegspektrometria) Németh Krisztina true true Németh Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707049 /api/authorship/106707049 Simon, József [Simon, József (2D korreláció ana...), szerző] Természettudományi Központ (PE / MK) 7 0.11111111 false false false Author 10049429 /api/author/10049429 Simon József (2D korreláció analízis) Simon József true 10049429 true Simon József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707050 /api/authorship/106707050 Csala, Miklós ✉ [Csala, Miklós (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 8 0.111 false false true Author 10000786 /api/author/10000786 Csala Miklós (Biokémia) Csala Miklós true 10000786 true Csala Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106707051 /api/authorship/106707051 Csámpai, Antal ✉ [Csámpai, Antal (Szerves kémia), szerző] Szerves Kémiai Tanszék (ELTE / TTK / KI) 9 0.111 false true true Author 10008627 /api/author/10008627 Csámpai Antal (Szerves kémia) Csámpai Antal true 10008627 true Csámpai Antal true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 23063508 /api/publicationidentifier/23063508 DOI: 10.3390/ijms24043456 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms24043456 https://doi.org/10.3390/ijms24043456 false true PublicationIdentifier 23244187 /api/publicationidentifier/23244187 WoS: 000938691600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000938691600001 https://www.webofscience.com/wos/woscc/full-record/000938691600001 true true PublicationIdentifier 23193775 /api/publicationidentifier/23193775 Scopus: 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 4<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10047778"><a href="/gui2/?type=authors&mode=browse&sel=10047778" target="_blank">Murányi József (<span class="authorship-author-name">Murányi József</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10093972"><a href="/gui2/?type=authors&mode=browse&sel=10093972" target="_blank">Duró Cintia (<span class="authorship-author-name">Jernei-Duró Cintia</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/Hevesy György Kémia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059086"><a href="/gui2/?type=authors&mode=browse&sel=10059086" target="_blank">Gurbi Bianka (<span class="authorship-author-name">Gurbi Bianka</span> <span class="authorAux-mtmt"> célzott daganatterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082532"><a href="/gui2/?type=authors&mode=browse&sel=10082532" target="_blank">Móra István (<span class="authorship-author-name">Móra István András</span> <span class="authorAux-mtmt"> Biomérnök</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040840"><a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga Attila (<span class="authorship-author-name">Varga Attila</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076057"><a href="/gui2/?type=authors&mode=browse&sel=10076057" target="_blank">Németh Krisztina (<span class="authorship-author-name">Németh Krisztina</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049429"><a href="/gui2/?type=authors&mode=browse&sel=10049429" target="_blank">Simon József (<span class="authorship-author-name">Simon József</span> <span class="authorAux-mtmt"> 2D korreláció analízis</span>) </a> </span> <span class="author-affil"><span title="Pannon Egyetem">PE</span>/<span title="Mérnöki Kar">MK</span>/Természettudományi Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós ✉ (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008627"><a href="/gui2/?type=authors&mode=browse&sel=10008627" target="_blank">Csámpai Antal ✉ (<span class="authorship-author-name">Csámpai Antal</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/Szerves Kémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33635331" target="_blank">Novel Erlotinib–Chalcone Hybrids Diminish Resistance in Head and Neck Cancer by Inducing Multiple Cell Death Mechanisms</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">4</span> <span class="page"> Paper 3456. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms24043456" target="_blank" href="https://doi.org/10.3390/ijms24043456"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000938691600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000938691600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85149015206" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85149015206"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36834866" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36834866&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 5 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;5 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33635331&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33635331</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K-129037) Támogató: OTKA, (NVKP_16-1-2016-0036), (2018-1.2.1-NKP-2018-00005) Támogató: NKFIH, (K124813), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (TKP2021-EGA-24) </div> <div class="lastModified">Utolsó módosítás: 2024.02.09. 20:14 Jernei-Duró Cintia (Szerves kémia) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, Budapest, H-1094, Hungary Department of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, Budapest, H-1117, Hungary MS Metabolomics Research Group, Centre for Structural Study, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Mag...</pre> </div></div>