https://m2.mtmt.hu/ eng 2026-05-30 13:57 JournalArticle 33628096 VALIDATED true Semmelweis Egyetem, Budapest, Hungary Eötvös Loránd Tudományegyetem, Department of Nuclear Chemistry, Budapest, Hungary Export Date: 18 November 2025; Cited By: 10; Correspondence Address: R. Zelkó; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, 7-9 Hőgyes Street, 1092, Hungary; email: zelko.romana@pharma.semmelweis-univ.hu; I. Sebe; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, 7-9 Hőgyes Street, 1092, Hungary; email: sebe.istvan@pharma.semmelweis-univ.hu 0 false 2026-05-22T17:52:44.228+0000 2025-11-18T11:48:10.429+0000 2023-02-07T17:53:35.846+0000 true 10080598 Benkő Beáta Mária /api/author/10080598 Author true 2026-01-29T19:19:34.608+0000 2023-03-23T11:35:56.688+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Majida Shokoya, Mariam Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices - A Systematic Review true true /api/journal/10024432 REVIEWED true false 10024432 false 10024432 true 1424-8247 Journal FOREIGN 16 2 252 252 39 2023 The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive method during the research process. In addition, the review aims to provide a comprehensive picture of additional medical and pharmaceutical uses, as the application of the PALS test method is limited and not widely known in this sector. We collected the scientific literature of the last 20 years (2002–2022) from several databases (PubMed, Embase, SciFinder-n, and Google Scholar) and evaluated the data gathered in relation to the combination of three directives, namely, the utilization of the PALS method, the testing of solid systems, and their application in the medical and pharmaceutical fields. The application of the PALS method is discussed based on three large groups: substances, drug delivery systems, and medical devices, starting with simpler systems and moving to more complex ones. The results are discussed based on the functionality of the PALS method, via microstructural analysis, the tracking of ageing and microstructural changes during stability testing, the examination of the effects of excipients and external factors, and defect characterization, with a strong emphasis on the benefits of this technique. The review highlights the wide range of possible applications of the PALS method as a non-invasive analytical tool for examining microstructures and monitoring changes; it can be effectively applied in many fields, alone or with complementary testing methods. true 2023 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/ph16020252 18 0 16 13 3 15 15 14 14 14 14 12 12 15 3 0 18 15 16 13 0 39 39 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 2 3 2 2024 0 6 6 6 6 2025 0 5 4 5 4 2026 0 4 3 4 3 Q1 false 10080598,10008061 false false false 2023-02-08T07:41:52.566+0000 Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Magkémiai Laboratórium (ML) (ELTE / TTK / KI) 5 29 2 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106639041 /api/authorship/106639041 1 0.2 true false Author 10087797 /api/author/10087797 Shokoya Mariam Majida true true Majida Shokoya Mariam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106639042 /api/authorship/106639042 2 0.2 false false Author 10080598 /api/author/10080598 Benkő Beáta Mária true true Benkő Beáta-Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106639043 /api/authorship/106639043 3 0.2 false false Author 10008061 /api/author/10008061 Süvegh Károly true 10008061 true Süvegh Károly true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106639044 /api/authorship/106639044 4 0.2 false false true Author 10002587 /api/author/10002587 Zelkó Romána true 10002587 true Zelkó Romána true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106639045 /api/authorship/106639045 5 0.2 false true true Author 10035401 /api/author/10035401 Sebe István true 10035401 true Sebe István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23049985 /api/publicationidentifier/23049985 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ph16020252 https://doi.org/10.3390/ph16020252 false true PublicationIdentifier 23256073 /api/publicationidentifier/23256073 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000940901000001 https://www.webofscience.com/wos/woscc/full-record/000940901000001 true true PublicationIdentifier 23193193 /api/publicationidentifier/23193193 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85148935547 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148935547 false true PublicationIdentifier 26313679 /api/publicationidentifier/26313679 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37259399 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37259399&dopt=Abstract false true Classification 12197 /api/classification/12197 true true SjrRating 11405946 /api/sjrrating/11405946 32 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true Q1 DIRECT true true /api/publication/33628096 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10087797"><a href="/gui2/?type=authors&mode=browse&sel=10087797" target="_blank">Majida Shokoya Mariam (<span class="authorship-author-name">Shokoya Mariam Majida</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080598"><a href="/gui2/?type=authors&mode=browse&sel=10080598" target="_blank">Benkő Beáta-Mária (<span class="authorship-author-name">Benkő Beáta Mária</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008061"><a href="/gui2/?type=authors&mode=browse&sel=10008061" target="_blank">Süvegh Károly (<span class="authorship-author-name">Süvegh Károly</span> <span class="authorAux-mtmt"> nukleáris tudományok</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Insititute of Chemistry">IC</span>/Laboratory of Nuclear Chemistry (ML)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002587"><a href="/gui2/?type=authors&mode=browse&sel=10002587" target="_blank">Zelkó Romána ✉ (<span class="authorship-author-name">Zelkó Romána</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035401"><a href="/gui2/?type=authors&mode=browse&sel=10035401" target="_blank">Sebe István ✉ (<span class="authorship-author-name">Sebe István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33628096" target="_blank">Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices - A Systematic Review</a></div> <div> <span class="journal-title">PHARMACEUTICALS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-8247">1424-8247</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">2</span> <span class="page"> Paper 252. 39 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ph16020252" target="_blank" href="https://doi.org/10.3390/ph16020252"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000940901000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000940901000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85148935547" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148935547"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37259399" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37259399&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 15 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;15 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33628096&sort=publishedYear,desc&sort=title"> Number of cited publications: 39 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33628096</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/33628096/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2025.11.18. 12:48 Gizella Áncsán (SE admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Semmelweis Egyetem, Budapest, Hungary Eötvös Loránd Tudományegyetem, Department of Nuclear Chemistry, Budapest, Hungary Export Date: 18 November 2025; Cited By: 10; Correspondence Address: R. Zelkó; University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, 7-9 Hőgyes Street, 1092, Hungary; email: zelko.romana@phar...</pre> </div></div>