https://m2.mtmt.hu/ hun 2026-09-21 12:36 JournalArticle 33623134 VALIDATED true 0 false 2026-07-16T14:23:42.477+0000 2025-06-27T12:32:27.132+0000 2023-02-06T07:29:11.548+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2025-06-27T12:32:27.310+0000 2025-06-27T12:32:27.310+0000 2023-06-21T07:22:24.243+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Loevner, Laurie A Efficacy and Safety of Gadopiclenol for Contrast-Enhanced MRI of the Central Nervous System The PICTURE Randomized Clinical Trial. true true /api/journal/2148 REVIEWED true false 2148 false 2148 true 0020-9996 1536-0210 Journal FOREIGN 58 5 307 313 307 7 2023 Developing new high relaxivity gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI) allowing dose reduction while maintaining similar diagnostic efficacy is needed, especially in the context of gadolinium retention in tissues. This study aimed to demonstrate that contrast-enhanced MRI of the central nervous system (CNS) with gadopiclenol at 0.05 mmol/kg is not inferior to gadobutrol at 0.1 mmol/kg, and superior to unenhanced MRI.PICTURE is an international, randomized, double-blinded, controlled, cross-over, phase III study, conducted between June 2019 and September 2020. Adult patients with CNS lesions were randomized to undergo 2 MRIs (interval, 2-14 days) with gadopiclenol (0.05 mmol/kg) then gadobutrol (0.1 mmol/kg) or vice versa. The primary criterion was lesion visualization based on 3 parameters (border delineation, internal morphology, and contrast enhancement), assessed by 3 off-site blinded readers. Key secondary outcomes included lesion-to-background ratio, enhancement percentage, contrast-to-noise ratio, overall diagnostic preference, and adverse events.Of the 256 randomized patients, 250 received at least 1 GBCA administration (mean [SD] age, 57.2 [13.8] years; 53.6% women). The statistical noninferiority of gadopiclenol (0.05 mmol/kg) to gadobutrol (0.1 mmol/kg) was achieved for all parameters and all readers (n = 236, lower limit 95% confidence interval of the difference ≥-0.06, above the noninferiority margin [-0.35], P < 0.0001), as well as its statistical superiority over unenhanced images (n = 239, lower limit 95% confidence interval of the difference ≥1.29, P < 0.0001).Enhancement percentage and lesion-to-background ratio were higher with gadopiclenol for all readers (P < 0.0001), and contrast-to-noise ratio was higher for 2 readers (P = 0.02 and P < 0.0001). Three blinded readers preferred images with gadopiclenol for 44.8%, 54.4%, and 57.3% of evaluations, reported no preference for 40.7%, 21.6%, and 23.2%, and preferred images with gadobutrol for 14.5%, 24.1%, and 19.5% (P < 0.001).Adverse events reported after MRI were similar for gadopiclenol (14.6% of patients) and gadobutrol (17.6%). Adverse events considered related to gadopiclenol (4.9%) and gadobutrol (6.9%) were mainly injection site reactions, and none was serious.Gadopiclenol at 0.05 mmol/kg is not inferior to gadobutrol at 0.1 mmol/kg for MRI of the CNS, confirming that gadopiclenol can be used at half the gadolinium dose used for other GBCAs to achieve similar clinical efficacy. true 2023 true true true false true false NONE 2026-07-16 false 71 0 71 71 1 71 67 63 70 71 71 71 71 71 0 0 71 71 71 71 0 1 1 Folyóiratcikk Journal Article 24 71 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 6 6 6 6 2024 0 26 26 26 26 2025 0 22 22 22 22 2026 0 17 17 17 17 D1 false false false false 2023-04-23T11:07:52.092+0000 Idegsebészeti Klinika (PTE / ÁOK); Idegsebészeti Tanszék (DE / ÁOK); Neurológiai Klinika (SE / AOK / K); Országos Klinikai Idegtudományi Intézet 4 34 4 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106600275 /api/authorship/106600275 1 0.143 true false true Loevner Laurie A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600276 /api/authorship/106600276 2 0.14285715 false false false Author 10101083 /api/author/10101083 Kolumbán Bálint true true Kolumban Balint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600277 /api/authorship/106600277 3 0.143 false false false Author 10055580 /api/author/10055580 Hutóczki Gábor true 10055580 true Hutóczki Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600278 /api/authorship/106600278 4 0.14285715 false false false Dziadziuszko Katarzyna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600279 /api/authorship/106600279 5 0.143 false false false Author 10000800 /api/author/10000800 Bereczki Dániel true 10000800 true Bereczki Daniel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600280 /api/authorship/106600280 6 0.143 false false false Author 10026954 /api/author/10026954 Bagó Attila György true 10026954 true Bago Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106600281 /api/authorship/106600281 7 0.14285715 false true false Pichiecchio Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 23024948 /api/publicationidentifier/23024948 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1097/RLI.0000000000000944 https://doi.org/10.1097/RLI.0000000000000944 false true PublicationIdentifier 23859121 /api/publicationidentifier/23859121 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000972163300001 https://www.webofscience.com/wos/woscc/full-record/000972163300001 true true PublicationIdentifier 25958931 /api/publicationidentifier/25958931 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85152618871 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152618871 false true PublicationIdentifier 23024947 /api/publicationidentifier/23024947 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36729404 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36729404&dopt=Abstract false true Classification 12162 /api/classification/12162 true true SjrRating 11397016 /api/sjrrating/11397016 106 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/33623134 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Loevner Laurie A ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10101083"><a href="/gui2/?type=authors&mode=browse&sel=10101083" target="_blank">Kolumban Balint (<span class="authorship-author-name">Kolumbán Bálint</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055580"><a href="/gui2/?type=authors&mode=browse&sel=10055580" target="_blank">Hutóczki Gábor (<span class="authorship-author-name">Hutóczki Gábor</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dziadziuszko Katarzyna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki Daniel (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026954"><a href="/gui2/?type=authors&mode=browse&sel=10026954" target="_blank">Bago Attila (<span class="authorship-author-name">Bagó Attila György</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil">Országos Klinikai Idegtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pichiecchio Anna </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33623134" target="_blank">Efficacy and Safety of Gadopiclenol for Contrast-Enhanced MRI of the Central Nervous System : The PICTURE Randomized Clinical Trial..</a></div> <div> <span class="journal-title">INVESTIGATIVE RADIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0020-9996">0020-9996</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1536-0210">1536-0210</a>)</span>: <span class="journal-volume">58</span> <span class="journal-issue">5</span> <span class="page"> pp 307-313 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1097/RLI.0000000000000944" target="_blank" href="https://doi.org/10.1097/RLI.0000000000000944"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000972163300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000972163300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85152618871" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85152618871"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36729404" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36729404&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 71</span> | Független: 71 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 63 | Scopus jelölt:&nbsp;70 | WoS/Scopus jelölt:&nbsp;71 | DOI jelölt:&nbsp;67 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33623134&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33623134</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.06.27. 14:32 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>