(TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium
(TKP-NVA-20)
(ICGEB CRP/HUN21-05_EC)
(739593) Támogató: Horizon 2020
(NKFIH K-125161)
(FEIF/646-4/2021-ITM_SZERZ)
Szakterületek:
Fogászat, szájsebészet és -gyógyászat
Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under
appropriate environmental cues, multipotency enables MSCs to serve as progenitors
for several lineage-specific, differentiated cell types. In vitro expansion and differentiation
of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons.
The neurogenic potential of MSCs makes them a promising, autologous source to restore
damaged tissue and as such, they have received much attention in the field of regenerative
medicine. Several stem cell pool candidates have been studied thus far, but only a
few of them showed neurogenic differentiation potential. Due to their embryonic ontology,
stem cells residing in the stroma of the dental pulp chamber are an exciting source
for in vitro neural cell differentiation. In this study, we review the key properties
of dental pulp stem cells (DPSCs), with a particular focus on their neurogenic potential.
Moreover, we summarize the various presently available methods used for neural differentiation
of human DPSCs also emphasizing the difficulties in reproducibly high production of
such cells. We postulate that because DPSCs are stem cells with very close ontology
to neurogenic lineages, they may serve as excellent targets for neuronal differentiation
in vitro and even for direct reprogramming.
