https://m2.mtmt.hu/ eng 2026-10-22 23:14 JournalArticle 33616443 VALIDATED true 0 false 2026-10-22T09:53:08.003+0000 2024-11-15T13:15:31.897+0000 2023-02-03T13:14:15.109+0000 true 10000768 Molnár Béla /api/author/10000768 Author true 10000768 2026-08-27T07:57:06.849+0000 2024-11-15T13:15:32.124+0000 true 10080073 Bolgár Andrea /api/admin/10080073 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080073 /api/admin/10080073 Bolgár Andrea true true 2024-10-17T17:10:18.585+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kalmár, Alexandra Patterns of Somatic Variants in Colorectal Adenoma and Carcinoma Tissue and Matched Plasma Samples from the Hungarian Oncogenome Program true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 15 3 907 907 24 2023 Analysis of circulating cell-free DNA (cfDNA) of colorectal adenoma (AD) and cancer (CRC) patients provides a minimally invasive approach that is able to explore genetic alterations. It is unknown whether there are specific genetic variants that could explain the high prevalence of CRC in Hungary. Whole-exome sequencing (WES) was performed on colon tissues (27 AD, 51 CRC) and matched cfDNAs (17 AD, 33 CRC); furthermore, targeted panel sequencing was performed on a subset of cfDNA samples. The most frequently mutated genes were APC, KRAS, and FBN3 in AD, while APC, TP53, TTN, and KRAS were the most frequently mutated in CRC tissue. Variants in KRAS codons 12 (AD: 8/27, CRC: 11/51 (0.216)) and 13 (CRC: 3/51 (0.06)) were the most frequent in our sample set, with G12V (5/27) dominance in ADs and G12D (5/51 (0.098)) in CRCs. In terms of the cfDNA WES results, tumor somatic variants were found in 6/33 of CRC cases. Panel sequencing revealed somatic variants in 8 out of the 12 enrolled patients, identifying 12/20 tumor somatic variants falling on its targeted regions, while WES recovered only 20% in the respective regions in cfDNA of the same patients. In liquid biopsy analyses, WES is less efficient compared to the targeted panel sequencing with a higher coverage depth that can hold a relevant clinical potential to be applied in everyday practice in the future. Funding 2023505 /api/funding/2023505 false true Funding 2023506 /api/funding/2023506 false true Funding 2023507 /api/funding/2023507 false true Funding 2023508 /api/funding/2023508 false true true 2023 true true true false true false GOLD 2026-10-22 true https://doi.org/10.3390/cancers15030907 9 0 9 7 2 9 9 7 8 9 9 7 7 7 2 0 9 7 9 7 0 7 7 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 2 2 2 2 2025 0 3 1 3 1 2026 0 2 2 2 2 Q1 false 10000768 false false false 2023-02-12T09:18:39.208+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Endokrinológiai Tanszék (SE / AOK / K / BOK); Komplex Rendszerek Fizikája Tanszék (ELTE / TTK / FizCsill_I); MTA-SE Molekuláris Medicina Kutatócsoport (SE / AOK / K / BOK) 13 36 4 13 0 true 10080073 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106565839 /api/authorship/106565839 1 0.077 true false true Author 10035287 /api/author/10035287 Kalmár Alexandra true 10035287 true Kalmár Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565840 /api/authorship/106565840 2 0.077 false false false Author 10001335 /api/author/10001335 Udvardyné Galamb Orsolya true 10001335 true Galamb Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565841 /api/authorship/106565841 3 0.077 false false false Author 10064551 /api/author/10064551 Szabó Gitta true 10064551 true Szabó Gitta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565842 /api/authorship/106565842 4 0.07692308 false false false Author 10060440 /api/author/10060440 Pipek Orsolya Anna true 10060440 true Pipek Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565843 /api/authorship/106565843 5 0.077 false false false Author 10042851 /api/author/10042851 Medgyes-Horváth Anna true 10042851 true Medgyes-Horváth Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565844 /api/authorship/106565844 6 0.077 false false false Author 10038772 /api/author/10038772 Barták Barbara Kinga true 10038772 true Barták Barbara K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565845 /api/authorship/106565845 7 0.077 false false false Author 10038783 /api/author/10038783 Nagy Zsófia Brigitta true 10038783 true Nagy Zsófia B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565846 /api/authorship/106565846 8 0.077 false false false Author 10079934 /api/author/10079934 Szigeti Krisztina Andrea true true Szigeti Krisztina A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565847 /api/authorship/106565847 9 0.077 false false false Author 10056823 /api/author/10056823 Zsigrai Sára true 10056823 true Zsigrai Sára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565848 /api/authorship/106565848 10 0.077 false false false Author 10000521 /api/author/10000521 Csabai István true 10000521 true Csabai István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565849 /api/authorship/106565849 11 0.077 false false false Author 10000070 /api/author/10000070 Igaz Péter true 10000070 true Igaz Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565850 /api/authorship/106565850 12 0.077 false false false Author 10000768 /api/author/10000768 Molnár Béla true 10000768 true Molnár Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106565851 /api/authorship/106565851 13 0.077 false true false Author 10024031 /api/author/10024031 Takács István true 10024031 true Takács István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22995404 /api/publicationidentifier/22995404 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cancers15030907 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PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36765865 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36765865&dopt=Abstract false true Classification 12215 /api/classification/12215 true true SjrRating 11403654 /api/sjrrating/11403654 79 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/33616443 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10035287"><a href="/gui2/?type=authors&mode=browse&sel=10035287" target="_blank">Kalmár Alexandra ✉ (<span class="authorship-author-name">Kalmár Alexandra</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/MTA-SE Molecular Medicine Research Unit; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001335"><a href="/gui2/?type=authors&mode=browse&sel=10001335" target="_blank">Galamb Orsolya (<span class="authorship-author-name">Udvardyné Galamb Orsolya</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/MTA-SE Molecular Medicine Research Unit</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064551"><a href="/gui2/?type=authors&mode=browse&sel=10064551" target="_blank">Szabó Gitta (<span class="authorship-author-name">Szabó Gitta</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060440"><a href="/gui2/?type=authors&mode=browse&sel=10060440" target="_blank">Pipek Orsolya (<span class="authorship-author-name">Pipek Orsolya Anna</span> <span class="authorAux-mtmt"> bioinformatika, big data, onkológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics and Astronomy">InstPhysicsAstro</span>/Department of Physics of Complex Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042851"><a href="/gui2/?type=authors&mode=browse&sel=10042851" target="_blank">Medgyes-Horváth Anna (<span class="authorship-author-name">Medgyes-Horváth Anna</span> <span class="authorAux-mtmt"> Sejtciklus</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics and Astronomy">InstPhysicsAstro</span>/Department of Physics of Complex Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038772"><a href="/gui2/?type=authors&mode=browse&sel=10038772" target="_blank">Barták Barbara K. (<span class="authorship-author-name">Barták Barbara Kinga</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038783"><a href="/gui2/?type=authors&mode=browse&sel=10038783" target="_blank">Nagy Zsófia B. (<span class="authorship-author-name">Nagy Zsófia Brigitta</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079934"><a href="/gui2/?type=authors&mode=browse&sel=10079934" target="_blank">Szigeti Krisztina A. (<span class="authorship-author-name">Szigeti Krisztina Andrea</span> <span class="authorAux-mtmt"> Daganatbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056823"><a href="/gui2/?type=authors&mode=browse&sel=10056823" target="_blank">Zsigrai Sára (<span class="authorship-author-name">Zsigrai Sára</span> <span class="authorAux-mtmt"> molekuláris gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000521"><a href="/gui2/?type=authors&mode=browse&sel=10000521" target="_blank">Csabai István (<span class="authorship-author-name">Csabai István</span> <span class="authorAux-mtmt"> Statisztikus fizika</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Physics and Astronomy">InstPhysicsAstro</span>/Department of Physics of Complex Systems</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000070"><a href="/gui2/?type=authors&mode=browse&sel=10000070" target="_blank">Igaz Péter (<span class="authorship-author-name">Igaz Péter</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia, klinikai molekul...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/MTA-SE Molecular Medicine Research Unit; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Endokrinológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000768"><a href="/gui2/?type=authors&mode=browse&sel=10000768" target="_blank">Molnár Béla (<span class="authorship-author-name">Molnár Béla</span> <span class="authorAux-mtmt"> belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/MTA-SE Molecular Medicine Research Unit; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024031"><a href="/gui2/?type=authors&mode=browse&sel=10024031" target="_blank">Takács István (<span class="authorship-author-name">Takács István</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33616443" target="_blank">Patterns of Somatic Variants in Colorectal Adenoma and Carcinoma Tissue and Matched Plasma Samples from the Hungarian Oncogenome Program</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">3</span> <span class="page"> Paper 907. 24 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cancers15030907" target="_blank" href="https://doi.org/10.3390/cancers15030907"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000933805400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000933805400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85147829386" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85147829386"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36765865" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36765865&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 9</span> | Independent citation: 7 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33616443&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33616443</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKVP_16-1-2016-0004 GRANT), (FIEK_16-1-2016-0005), (PIACI-KFI-2021-000298), (TKP2021-EGA-24) </div> <div class="lastModified">Last Modified: 2024.11.15. 14:15 Andrea Bolgár (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Centrally managed 2024.10.17. 19:10 Gusztáv Ladányi (MTMT API user, admin) Andrea Bolgár (MTMT ellenőrzés admin5) </div> </div></div>