https://m2.mtmt.hu/ hun 2026-09-20 17:48 JournalArticle 33588788 VALIDATED true Export Date: 3 February 2023 CODEN: PAREA 0 false 2026-08-27T10:34:24.994+0000 2025-06-24T13:33:45.451+0000 2023-01-24T10:28:36.346+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-07-15T18:03:43.026+0000 2023-01-30T10:48:51.168+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Ferdinandy, Péter Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning true true /api/journal/3623 REVIEWED true false 3623 false 3623 true 0031-6997 1521-0081 Journal FOREIGN 75 1 159 216 159 58 2023 Preconditioning, postconditioning and remote conditioning of the myocardium enhance the ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to provide novel therapeutic paradigms for cardioprotection. While many signaling pathways leading to endogenous cardioprotection have been elucidated in experimental studies over the last 30 years, no cardioprotective drug is on the market yet for that indication. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic preclinical evaluation of promising cardioprotective therapies prior to their clinical evaluation, since ischemic heart disease in humans is a complex disorder caused by or associated with cardiovascular risk factors and comorbidities. These risk factors and comorbidities induce fundamental alterations in cellular signaling cascades that affect the development of ischemia/reperfusion injury and responses to cardioprotective interventions. Moreover, some of the medications used to treat these comorbidities may impact on cardioprotection by again modifying cellular signaling pathways. The aim of this article is to review the recent evidence that cardiovascular risk factors as well as comorbidities and their medications may modify the response to cardioprotective interventions. We emphasize the critical need for taking into account the presence of cardiovascular risk factors as well as comorbidities and their concomitant medications when designing preclinical studies for the identification and validation of cardioprotective drug targets and clinical studies. This will hopefully maximize the success rate of developing rational approaches to effective cardioprotective therapies for the majority of patients with multiple comorbidities. Significance Statement Ischemic heart disease is a major cause of mortality, however, there are still no cardioprotective drugs on the market. Most studies on cardioprotection have been undertaken in animal models of ischemia/reperfusion in the absence of comorbidities, however, ischemic heart disease develops with other systemic disorders e.g. hypertension, hyperlipidemia, diabetes, atherosclerosis, etc. Here we focus on the preclinical and clinical evidence showing how these comorbidities and their routine medications affect ischemia/reperfusion injury and interfere with cardioprotective strategies. 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32 2025 0 55 44 55 44 2026 0 17 16 17 16 D1 false 10010125 false false false 2023-01-29T10:48:50.696+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 17 1 13 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106421168 /api/authorship/106421168 1 0.077 true false true Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421169 /api/authorship/106421169 2 0.07692308 false false false Andreadou Ioanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421170 /api/authorship/106421170 3 0.07692308 false false false Baxter Gary F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421171 /api/authorship/106421171 4 0.07692308 false false false Botker Hans Erik true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421172 /api/authorship/106421172 5 0.07692308 false false false Davidson Sean M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421173 /api/authorship/106421173 6 0.07692308 false false false Dobrev Dobromir true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421174 /api/authorship/106421174 7 0.07692308 false false false Gersh Bernard J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421175 /api/authorship/106421175 8 0.07692308 false false false Heusch Gerd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421176 /api/authorship/106421176 9 0.07692308 false false false Lecour Sandrine true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421177 /api/authorship/106421177 10 0.07692308 false false false Ruiz-Meana Marisol true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421178 /api/authorship/106421178 11 0.07692308 false false false Zuurbier Coert J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421179 /api/authorship/106421179 12 0.077 false true false Hausenloy Derek J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106421180 /api/authorship/106421180 13 0.07692308 false true false Schulz Rainer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22924657 /api/publicationidentifier/22924657 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1124/pharmrev.121.000348 https://doi.org/10.1124/pharmrev.121.000348 false true 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36753049 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36753049&dopt=Abstract true true Classification 12197 /api/classification/12197 true true SjrRating 11406112 /api/sjrrating/11406112 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true D1 DIRECT true true /api/publication/33588788 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter ✉ (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Andreadou Ioanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Baxter Gary F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Botker Hans Erik </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Davidson Sean M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dobrev Dobromir </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gersh Bernard J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heusch Gerd </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lecour Sandrine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ruiz-Meana Marisol </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zuurbier Coert J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hausenloy Derek J<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33588788" target="_blank">Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning</a></div> <div> <span class="journal-title">PHARMACOLOGICAL REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0031-6997">0031-6997</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-0081">1521-0081</a>)</span>: <span class="journal-volume">75</span> <span class="journal-issue">1</span> <span class="page"> pp 159-216 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="10.1124/pharmrev.121.000348" target="_blank" href="https://doi.org/10.1124/pharmrev.121.000348"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000958833700006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000958833700006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85146466594" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146466594"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36753049" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36753049&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 138</span> | Független: 106 | Függő: 32 | Nem jelölt: 0 | WoS jelölt: 130 | Scopus jelölt:&nbsp;117 | WoS/Scopus jelölt:&nbsp;133 | DOI jelölt:&nbsp;132 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33588788&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 59 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33588788</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, (Therapeutic Development thematic program of the Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2025.06.24. 15:33 Tóth-Lipták Péter (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 3 February 2023 CODEN: PAREA</pre> </div></div>