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      <title>The necessity of pyloric drainage in esophagectomies: protocol of a meta-analysis and a systematic review of randomized controlled trials.</title>
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      <abstractText>Background: Esophageal carcinoma is the 8th most common malignant tumour in the world with more than 600 000 cases (3.1% of all), while being the 6th most common reason of tumour mortality, causing more than 500 000 deaths (5.5% of all) annually. The 1, 3 and 5 year-prevalence are 2.4%, 1.6% and 1.3% respectively. The question of this meta-analysis is whether pyloric drainage is preferable over the lack of pyloric drainage during elective esophagectomies in patients suffering from esophageal cancer, regarding mortality, anastomosis leakage, respiratory morbidity, vomiting, gastric emptying time. Methods: We plan to identify randomized controlled trials to investigate the question by performing extensive search in multiple databases. Based on of predefined criteria, two independent authors will perform the steps of selection, after which appropriate statistical analysis will be performed to identify potential significant differences. Cochrane Risk of Bias Tool 2, and GRADE approach will be used to estimate the risk of bias and quality of results. Dissemination plans: We plan to distribute our results in peer-reviewed journal.</abstractText>
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      <directInstitutesForSort>Bioanalitikai Intézet (PTE / ÁOK); Sebészeti Klinika (PTE / ÁOK); Sürgősségi Orvostani Tanszék, Sürgősségi Betege... (PTE / ÁOK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs medicina kutatócsoport (PTE / SZKK)</directInstitutesForSort>
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Sindler &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;P., Hegyi&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10016574&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10016574&quot; target=&quot;_blank&quot;&gt;A., Papp&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; &lt;/div &gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;33588407&quot; mtid=&quot;33588407&quot; target=&quot;_blank&quot;&gt;The necessity of pyloric drainage in esophagectomies: protocol of a meta-analysis and a systematic review of randomized controlled trials.&lt;/a&gt; &lt;span class=&quot;page&quot;&gt; &lt;/span&gt; (2022) &lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;description0&quot;&gt;medRxiv &lt;/span &gt;, &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;10.1101/2022.08.24.22279164&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1101/2022.08.24.22279164&quot;&gt; Preprint DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;PPRN:12370244&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/PPRN:12370244&quot;&gt; WoS preprint &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;short-pub-prop-list&quot;&gt; &lt;span class=&quot;deleted-record&quot;&gt;Centrally managed&lt;/span&gt; &lt;span class=&quot;short-pub-mtid&quot;&gt; Publication:33588407 &lt;/span&gt; &lt;span class=&quot;status-holder&quot;&gt;&lt;span class=&quot;status-data status-APPROVED&quot;&gt; Published &lt;/span&gt;&lt;/span&gt; &lt;span class=&quot;pub-core&quot;&gt;Core &lt;/span&gt; &lt;span class=&quot;pub-type&quot;&gt;Miscellaneous (Publication in repository ) &lt;/span&gt; &lt;!-- &amp;&amp; !record.category.scientific --&gt; &lt;span class=&quot;pub-category&quot;&gt;Scientific&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</template><template2>&lt;div class=&quot;PublicationOther Publication long-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;img title=&quot;Forrásközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-core-icon.png&quot;&gt; &lt;div class=&quot;autype autype0&quot;&gt; &lt;span class=&quot;author-name&quot; &gt;A. Csontos &lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10071583&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10071583&quot; target=&quot;_blank&quot;&gt;D. Nemeth (&lt;span class=&quot;authorship-author-name&quot;&gt;Németh Dávid&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Biostatisztikus&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute of Bioanalysis; &lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute for Translational Medicine&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10070994&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10070994&quot; target=&quot;_blank&quot;&gt;L. Szako (&lt;span class=&quot;authorship-author-name&quot;&gt;Szakó Lajos&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute for Translational Medicine; &lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Szentágothai Research Centre&quot;&gt;SZRC&lt;/span&gt;/Translational Medicine Research Group; &lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Department of Emergency Medicine&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; &gt;G. Berke &lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; &gt;L. D. Sindler &lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;P. Hegyi (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Péter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Institute for Translational Medicine&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10016574&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10016574&quot; target=&quot;_blank&quot;&gt;A. Papp (&lt;span class=&quot;authorship-author-name&quot;&gt;Papp András&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Sebészet, Gasztroenterológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Pécs&quot;&gt;UP&lt;/span&gt;/&lt;span title=&quot;Medical School&quot;&gt;UPMS&lt;/span&gt;/Surgery Clinic&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;33588407&quot; target=&quot;_blank&quot;&gt;The necessity of pyloric drainage in esophagectomies: protocol of a meta-analysis and a systematic review of randomized controlled trials.&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;description&quot;&gt; &lt;div class=&quot;description0&quot;&gt;medRxiv &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;country&quot;&gt; Country: &lt;span class=&quot;publishedYear&quot;&gt;(2022)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-footer&quot;&gt; &lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Language: English | &lt;/span&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;10.1101/2022.08.24.22279164&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1101/2022.08.24.22279164&quot;&gt; Preprint DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;PPRN:12370244&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/PPRN:12370244&quot;&gt; WoS preprint &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Publication: 33588407&lt;/span&gt; | &lt;span class=&quot;status-data status-APPROVED&quot;&gt; Published &lt;/span&gt; Core | &lt;span class=&quot;type-subtype&quot;&gt;Miscellaneous ( Publication in repository ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Scientific&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS TAGGED&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Last Modified: 2023.08.31. 13:00 Róbert Milánkovics (PTE ÁOK admin 4) &lt;/div&gt; &lt;div class=&quot;lockedBy&quot;&gt;Centrally managed 2025.04.28. 15:21 Katalin Lévayné Deseő (MTMT Központi admin) &lt;/div&gt; &lt;/div&gt;&lt;/div&gt;</template2>
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