https://m2.mtmt.hu/ eng 2026-04-17 04:57 JournalArticle 33580336 VALIDATED true 0 false 2026-04-10T07:32:19.644+0000 2025-10-30T10:42:38.125+0000 2023-01-20T20:03:23.886+0000 true 10081959 Szalóky-Siki Ágnes /api/admin/10081959 Admin Ágnes Szalóky-Siki (SE_ÁOK_Transzlációs_Admin5_SZSÁ, admin) true 2025-10-30T10:42:38.364+0000 2025-10-30T10:42:38.364+0000 2024-12-06T18:03:11.100+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 Admin 10073918 /api/admin/10073918 Marcell Kovács (MTMT Közp., admin) Kovács Marcell true true 2025-10-07T15:13:22.424+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Szabó, Anett true true /api/journal/10007253 REVIEWED REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 1477-7827 1477-7827 true false 10007253 false 10007253 true 1477-7827 1477-7827 Journal FOREIGN 21 1 5 5 9 2023 Infertility affects one in every six couples in developed countries, and approximately 50% is of male origin. In 2021, sperm DNA fragmentation (SDF) testing became an evidence-based test for fertility evaluations depicting fertility more clearly than standard semen parameters. Therefore, we aimed to summarize the potential prognostic factors of a higher SDF.We conducted a systematic search in three medical databases and included studies investigating any risk factors for SDF values. We calculated mean differences (MD) in SDF with 95% confidence interval (CI) for exposed and non-exposed individuals.We included 190 studies in our analysis. In the group of associated health conditions, varicocele (MD = 13.62%, CI: 9.39-17.84) and impaired glucose tolerance (MD = 13.75%, CI: 6.99-20.51) had the most significant increase in SDF. Among malignancies, testicular tumors had the highest impact, with a maximum of MD = 11.3% (CI: 7.84-14.76). Among infections, the overall effects of both Chlamydia and HPV were negligible. Of lifestyle factors, smoking had the most disruptive effect on SDF - an increase of 9.19% (CI: 4.33-14.06). Different periods of sexual abstinence did not show significant variations in SDF values. Age seemed to have a more drastic effect on SDF from age 50 onwards, with a mean difference of 12.58% (CI: 7.31-17.86). Pollution also had a detrimental effect - 9.68% (CI: 6.85-12.52).Of the above risk factors, varicocele, impaired glucose tolerance, testicular tumors, smoking, pollution, and paternal age of over 50 were associated with the highest SDF.CRD42021282533. Funding 2022450 /api/funding/2022450 (Open access funding provided by Semmelweis University) false true true 2023 true true true false true false GOLD 2026-04-10 true https://doi.org/10.1186/s12958-023-01054-0 78 0 78 76 2 78 75 69 69 78 78 76 76 76 2 0 78 76 78 76 0 1 1 Folyóiratcikk Journal Article 24 78 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 11 11 11 11 2024 0 25 25 25 25 2025 0 33 31 33 31 2026 0 9 9 9 9 D1 false 10086438,10057579 false false false 2023-01-22T07:44:20.865+0000 Intervenciós Radiológiai Tanszék (SE / AOK / K); Pankreász Betegségek Intézete (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Urológiai Klinika (SE / AOK / K) 10 55 6 11 0 true 10073918 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 106376795 /api/authorship/106376795 Szabó, Anett [Szabó, Anett (urológia, andrológia), author] Department of Urology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 1 0.091 true false false Author 10086438 /api/author/10086438 Anett Szabó (urológia, andrológia) Szabó Anett true true Szabó Anett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376796 /api/authorship/106376796 Váncsa, Szilárd [Váncsa, Szilárd (Orvostudomány, eg...), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 2 0.091 false false false Author 10071961 /api/author/10071961 Szilárd Váncsa (Orvostudomány, egészségtudomány) Váncsa Szilárd true true Váncsa Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376797 /api/authorship/106376797 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 3 0.091 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376798 /api/authorship/106376798 Váradi, Alex [Váradi, Alex (Biológia), author] Centre for Translational Medicine (SU / KSZE) 4 0.091 false false false Author 10057579 /api/author/10057579 Alex Váradi (Biológia) Váradi Alex true 10057579 true Váradi Alex true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376799 /api/authorship/106376799 Forintos, Attila 5 0.09090909 false false false Forintos Attila true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376800 /api/authorship/106376800 Filipov, Teodóra [Filipov, Teodóra (Orvostudomány, eg...), author] Intervenciós Radiológiai Tanszék (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 6 0.091 false false false Author 10086478 /api/author/10086478 Teodóra Filipov (Orvostudomány, egészségtudomány) Filipov Teodóra true true Filipov Teodóra true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376801 /api/authorship/106376801 Ács, Júlia [Ács, Júlia (Urológia), author] Department of Urology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 7 0.091 false false false Author 10092650 /api/author/10092650 Júlia Ács (Urológia) Ács Júlia true true Ács Júlia true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376802 /api/authorship/106376802 Ács, Nándor [Ács, Nándor (Szülészet-nőgyógy...), author] Centre for Translational Medicine (SU / KSZE); Department of Obsterics and Gynecology Üllői St... (SU / FM / C / DOG) 8 0.091 false false false Author 10013998 /api/author/10013998 Nándor Ács (Szülészet-nőgyógyászat) Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376803 /api/authorship/106376803 Szarvas, Tibor [Szarvas, Tibor (urológia), author] Department of Urology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 9 0.091 false false false Author 10052466 /api/author/10052466 Tibor Szarvas (urológia) Szarvas Tibor true 10052466 true Szarvas Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376804 /api/authorship/106376804 Nyirády, Péter [Nyirády, Péter (Urológia), author] Department of Urology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 10 0.091 false false false Author 10013343 /api/author/10013343 Péter Nyirády (Urológia) Nyirády Péter true 10013343 true Nyirády Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 106376805 /api/authorship/106376805 Kopa, Zsolt ✉ [Kopa, Zsolt (Andrológia, urológia), author] Department of Urology (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 11 0.091 false true true Author 10013889 /api/author/10013889 Zsolt Kopa (Andrológia, urológia) Kopa Zsolt true 10013889 true Kopa Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 22887058 /api/publicationidentifier/22887058 DOI: 10.1186/s12958-023-01054-0 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12958-023-01054-0 https://doi.org/10.1186/s12958-023-01054-0 false true PublicationIdentifier 23113476 /api/publicationidentifier/23113476 WoS: 000913471200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000913471200001 https://www.webofscience.com/wos/woscc/full-record/000913471200001 true true PublicationIdentifier 22959782 /api/publicationidentifier/22959782 Scopus: 85146485543 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85146485543 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146485543 false true PublicationIdentifier 22887057 /api/publicationidentifier/22887057 PubMed: 36653793 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36653793 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36653793&dopt=Abstract false true Classification 12358 /api/classification/12358 Meta-analysis true true Classification 12305 /api/classification/12305 Urology true true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11413610 /api/sjrrating/11413610 sjr:D1 (2023) Scopus - Reproductive Medicine REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 1477-7827 1477-7827 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2743 /api/classificationexternal/2743 Scopus - Reproductive Medicine true 2743 true D1 DIRECT true true /api/publication/33580336 Szabó Anett et al. Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation : a systematic review and meta-analysis. (2023) REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 1477-7827 1477-7827 21 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10086438"><a href="/gui2/?type=authors&mode=browse&sel=10086438" target="_blank">Szabó Anett (<span class="authorship-author-name">Szabó Anett</span> <span class="authorAux-mtmt"> urológia, andrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071961"><a href="/gui2/?type=authors&mode=browse&sel=10071961" target="_blank">Váncsa Szilárd (<span class="authorship-author-name">Váncsa Szilárd</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057579"><a href="/gui2/?type=authors&mode=browse&sel=10057579" target="_blank">Váradi Alex (<span class="authorship-author-name">Váradi Alex</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Forintos Attila </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086478"><a href="/gui2/?type=authors&mode=browse&sel=10086478" target="_blank">Filipov Teodóra (<span class="authorship-author-name">Filipov Teodóra</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Intervenciós Radiológiai Tanszék; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092650"><a href="/gui2/?type=authors&mode=browse&sel=10092650" target="_blank">Ács Júlia (<span class="authorship-author-name">Ács Júlia</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády Péter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013889"><a href="/gui2/?type=authors&mode=browse&sel=10013889" target="_blank">Kopa Zsolt ✉ (<span class="authorship-author-name">Kopa Zsolt</span> <span class="authorAux-mtmt"> Andrológia, urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33580336" target="_blank">Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation : a systematic review and meta-analysis</a></div> <div> <span class="journal-title">REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-7827">1477-7827</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-7827">1477-7827</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">1</span> <span class="page"> Paper 5. 9 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12958-023-01054-0" target="_blank" href="https://doi.org/10.1186/s12958-023-01054-0"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000913471200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000913471200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85146485543" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146485543"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36653793" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36653793&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Reproductive Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Obstetrics and Gynecology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 78</span> | Independent citation: 76 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 69 | Number of citations in Scopus:&nbsp;69 | WoS/Scopus assigned:&nbsp;78 | Number of citations with DOI:&nbsp;75 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33580336&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33580336</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Last Modified: 2025.10.30. 11:42 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2025.10.07. 17:13 Marcell Kovács (MTMT Közp., admin) </div> </div></div>