https://m2.mtmt.hu/ eng 2026-04-15 14:55 JournalArticle 33577682 VALIDATED true 0 false 2026-04-15T06:51:30.542+0000 2024-11-28T08:16:50.368+0000 2023-01-20T09:59:11.242+0000 true 10067747 Reményiné Kállai Zsuzsa /api/admin/10067747 Admin true 2024-11-28T08:16:51.087+0000 2024-11-28T08:16:51.087+0000 2023-05-23T06:03:07.122+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2026-04-15T06:50:15.073+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Fekete, Klára Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke : A prospective single center study true true /api/journal/10020902 REVIEWED true false 10020902 false 10020902 true 1664-2295 1664-2295 Journal FOREIGN 14 1 1080046 1080046 2023 Introduction: Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) is an effective treatment with a 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the risk factors and long-term clinical outcomes of ICH in patients after rt-PA treatment. Methods: Consecutive patients with AIS, thrombolysed at the Department of Neurology, University of Debrecen, between 1 January 2004 and 31 August 2016 were enrolled prospectively. Risk factors, stroke severity based on the National Institute of Health Stroke Scale (NIHSS), functional outcome using the modified Rankin scale, and mortality at 1 year were compared in patients with and without ICH following rt-PA treatment. We evaluated clinical characteristics and prognosis by hemorrhage type based on the Heidelberg Bleeding Classification. Descriptive statistics, the chi-square test, the Mann–Whitney U-test, ANOVA, the Kruskal–Wallis test, a survival analysis, and logistic regression were performed as appropriate. Results: Out of 1,252 patients with thrombolysis, ICH developed in 138 patients, with 37 (2.95%) being symptomatic. Mean ages in the ICH and non-ICH groups differed significantly (p = 0.041). On admission, the 24-h NIHSS after thrombolysis was higher in patients with ICH (p < 0.0001). Large vessel occlusion was more prevalent in patients with ICH (p = 0.0095). The ICH risk was lower after intravenous thrombolysis than intra-arterial or combined thrombolysis (p < 0.0001). Both at 3 months and 1 year, the outcome was worse in patients with ICH compared to patients without ICH group (p < 0.0001). Mortality and poor outcome were more prevalent in all hemorrhage types with a tendency for massive bleeding associated with unfavorable prognosis. At 3 months with the logistic regression model, the worse outcome was detected in patients with ICH after thrombolysis, at 1 year in patients with ICH after thrombolysis and smoking. Discussion: Older age, higher NIHSS, large vessel occlusion, and intra-arterial thrombolysis may correlate with ICH. The unfavorable outcome is more common in patients with ICH. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patient's prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA. Copyright © 2023 2023 true true true false true false GOLD 2026-04-15 true https://doi.org/10.3389/fneur.2023.1080046 19 0 16 15 2 16 13 10 11 12 12 11 11 17 2 0 19 17 16 15 0 4 4 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 3 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 1 2 1 2024 0 6 5 6 5 2025 0 10 10 10 10 2026 0 1 1 1 1 Q2 false 10038837,10039291,10002463,10058707 false false false 2023-04-20T08:59:17.095+0000 Gyógyszerfelügyelet és Gyógyszergazdálkodási Ta... (DE / GYTK); Neurológiai Klinika (DE / KK); Neurológiai Tanszék (DE / ÁOK); Politikatudományi és Szociológiai Intézet (DE / BTK) 6 17 4 7 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106367650 /api/authorship/106367650 1 0.143 true false Author 10038837 /api/author/10038837 Fekete Klára true 10038837 true Fekete Klára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367651 /api/authorship/106367651 2 0.143 false false Author 10087526 /api/author/10087526 Héja Máté true true Héja Máté true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367652 /api/authorship/106367652 3 0.143 false false Author 10039291 /api/author/10039291 Márton Sándor József true 10039291 true Márton Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367653 /api/authorship/106367653 4 0.14285715 false false Tóth Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367654 /api/authorship/106367654 5 0.143 false false Author 10058707 /api/author/10058707 Horváth László true 10058707 true Horváth László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367655 /api/authorship/106367655 6 0.14285715 false false Author 10038812 /api/author/10038812 Harman Aletta Andrea true 10038812 true Harman Aletta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106367656 /api/authorship/106367656 7 0.14285715 false true Author 10002463 /api/author/10002463 Fekete István true 10002463 true Fekete István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22876266 /api/publicationidentifier/22876266 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fneur.2023.1080046 https://doi.org/10.3389/fneur.2023.1080046 false true PublicationIdentifier 23635195 /api/publicationidentifier/23635195 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000932236400001 https://www.webofscience.com/wos/woscc/full-record/000932236400001 false true PublicationIdentifier 23172935 /api/publicationidentifier/23172935 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85148346981 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148346981 false true PublicationIdentifier 23172936 /api/publicationidentifier/23172936 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36816554 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36816554&dopt=Abstract false true Classification 12124 /api/classification/12124 true true SjrRating 11402044 /api/sjrrating/11402044 104 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true Q2 DIRECT true true /api/publication/33577682 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10038837"><a href="/gui2/?type=authors&mode=browse&sel=10038837" target="_blank">Fekete Klára (<span class="authorship-author-name">Fekete Klára</span> <span class="authorAux-mtmt"> neurológia, klinikai neurofiziologia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087526"><a href="/gui2/?type=authors&mode=browse&sel=10087526" target="_blank">Héja Máté (<span class="authorship-author-name">Héja Máté</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Klinikai Központ">KK</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039291"><a href="/gui2/?type=authors&mode=browse&sel=10039291" target="_blank">Márton Sándor (<span class="authorship-author-name">Márton Sándor József</span> <span class="authorAux-mtmt"> alkalmazott statisztika, társadalomtudományok m...</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Arts">Faculty of Arts</span>/Institute of Political Science and Sociology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóth Judit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058707"><a href="/gui2/?type=authors&mode=browse&sel=10058707" target="_blank">Horváth László (<span class="authorship-author-name">Horváth László</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Pharmacy">Faculty of Pharmacy</span>/Gyógyszerfelügyelet és Gyógyszergazdálkodási Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038812"><a href="/gui2/?type=authors&mode=browse&sel=10038812" target="_blank">Harman Aletta (<span class="authorship-author-name">Harman Aletta Andrea</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002463"><a href="/gui2/?type=authors&mode=browse&sel=10002463" target="_blank">Fekete István (<span class="authorship-author-name">Fekete István</span> <span class="authorAux-mtmt"> Idegbetegségek, neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33577682" target="_blank">Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke : A prospective single center study</a></div> <div> <span class="journal-title">FRONTIERS IN NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2295">1664-2295</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-2295">1664-2295</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 1080046. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fneur.2023.1080046" target="_blank" href="https://doi.org/10.3389/fneur.2023.1080046"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000932236400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000932236400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85148346981" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148346981"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36816554" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36816554&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Neurology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 19</span> | Independent citation: 17 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;11 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33577682&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33577682</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.11.28. 09:16 Magdolna Király (DE admin 4) </div> <div class="lockedBy">Centrally managed 2026.04.15. 08:50 György Wolf (MTMT Központi admin) </div> </div></div>