Aldosterone as a stress hormone

Zelena, D [Zelena, Dóra (Neuroendokrinológia), szerző] Magatartásélettan és Stressz Kutatócsoport (KOKI / MO)

Angol nyelvű Tudományos Könyvfejezet (Könyvrészlet)
    Stress is an important pathogenic factor in many disorders and the hypothalamic-pituitary-adrenocortical axis is one of the main components of stress-adaptation. The endhormones of the axis are glucocorticoids, however, the pituitary component of the axis, adrenocorticotropin is a potent regulator of mineralocorticoid secretion as well. The primary role of mineralocorticoids is the regulation of salt-water homeostasis, which function can be a key element of stress-adaptation. In this respect the perinatal period seems to be especially important, as the water content of a newborn is even higher than that of an adult. Therefore its regulated maintenance seems to be utmost important. Moreover, positive developmental impact of low stressor-induced glucocorticoid levels in early development has been also recognized for a long time. Indeed, our studies using early postnatal rats confirmed that at this age-group animals react to stressors with higher mineralo- (aldosterone) than glucocorticoid (corticosterone) elevation. However, this reactivity type changes with age. Namely, in adults the same stressor triggered higher corticosterone and lower aldosterone secretion. In this review we aim to summarize the present knowledge about the role of aldosterone in stress adaptation with special emphasize to age-dependent changes. © 2017 Nova Science Publishers, Inc.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-05-17 15:01