https://m2.mtmt.hu/hun2024-03-28 19:18JournalArticle3356697APPROVEDtrueLab. “Neuropeptide”, Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 23, Sofia, 1113, Bulgaria
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest, H-1083, Hungary
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. bl. 21, Sofia, 1113, Bulgaria
Faculty of Biology, Sofia University St. Kliment Ohridski, Dragan Tsankov Str. 8, Sofia, 1164, Bulgaria
Cited By :10
Export Date: 7 September 2021
CODEN: BRBUD
Correspondence Address: Rakovska, A.; Lab. “Neuropeptide”, Acad. G. Bonchev Str., bl. 23, Bulgaria; email: arakovska@yahoo.com
Chemicals/CAS: 3 o methyldopamine, 554-52-9; 3,4 dihydroxyphenylacetic acid, 102-32-9; acetaldehyde, 75-07-0; cocaine and amphetamine regulated transcript peptide, 213994-61-7; dopamine, 51-61-6, 62-31-7; homovanillic acid, 306-08-1; hydroxytyrosol, 10597-60-1; noradrenalin, 1407-84-7, 51-41-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; phenethyl alcohol, 60-12-8; 3,4-dihydroxyphenylacetaldehyde; 3,4-Dihydroxyphenylacetic Acid; 3,4-dihydroxyphenylethanol; 3-methoxytyramine; Cocaine; cocaine- and amphetamine-regulated transcript protein (55-102); Dopamine; dopamine quinone; Dopamine Uptake Inhibitors; Homovanillic Acid; Nerve Tissue Proteins; Norepinephrine; Peptide Fragments; Phenylethyl Alcohol02018-10-02T08:54:25.000+0000false33566972024-03-28T11:23:50.790+00002021-03-31T07:07:44.694+00002018-04-08T23:54:28.000+0000true91BaranyiMária
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REVIEWEDtruefalse796false796true0361-92301873-2747JournalFOREIGN13424625224672017CART (Cocaine- and Amphetamine-Regulated Transcript) peptide is a neurotransmitter naturally occurring in the CNS and found mostly in nucleus accumbens, ventrotegmental area, ventral pallidum, amygdalae and striatum, brain regions associated with drug addiction. In the nucleus accumbens, known for its significant role in motivation, pleasure, reward and reinforcement learning, CART peptide inhibits cocaine and amphetamine-induced dopamine-mediated increases in locomotor activity and behavior, suggesting a CART peptide interaction with the dopaminergic system. Thus in the present study, we examined the effect of CART (55-102) peptide on the basal, electrical field stimulation-evoked (EFS-evoked) (30V, 2Hz, 120 shocks) and returning basal dopamine (DA) release and on the release of the DA metabolites 3,4-dihydroxyphenyl acetaldehyde (DOPAL), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3,4-dihydroxyphenylethanol (DOPET), 3-methoxytyramine (3-MT) as well as on norepinephrine (NE) and dopamine-o-quinone (Daq) in isolated mouse nucleus accumbens, in a preparation, in which any CART peptide effects on the dendrites or soma of ventral tegmental projection neurons have been excluded. We further extended our study to assess the effect of CART (55-102) peptide on basal cocaine-induced release of dopamine and its metabolites DOPAL, DOPAC, HVA, DOPET and 3-MT as well as on NE and Daq. To analyze the amount of [(3)H]dopamine, dopamine metabolites, Daq and NE in the nucleus accumbens superfusate, a high-pressure liquid chromatography (HPLC), coupled with electrochemical, UV and radiochemical detections was used. CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET. At the same concentration, 0.1muM, CART (55-102) peptide did not have any effect on the release of noradrenaline. In the presence of CART (55-102) peptide, 0.1muM, the effect of cocaine, 30muM, on the basal dopamine release was inhibited and the effect on the basal DOPAC release substantially increased. To our knowledge, our findings are the first to show direct neurochemical evidence that CART (55-102) peptide plays a neuromodulatory role on the dopaminergic reward system by decreasing dopamine in the mouse nucleus accumbens and by attenuating cocaine-induced effects on dopamine release.2018660095truetruetruefalsetruefalsePAY2024-03-28false140141401414141414141414140014141414066FolyóiratcikkJournal Article2413KönyvrészletChapter in Book251KönyvBook230Egyéb konferenciaközleményConference paper310Egyéb konferenciakötetConference proceedings320Oltalmi formákProtection forms260DisszertációThesis280EgyébMiscellaneous290AlkotásAchievement220Kutatási adatResearch data330FolyóiratcikkJournal Article24000KönyvrészletChapter in Book25000KönyvBook23000Egyéb konferenciaközleményConference paper31000Egyéb konferenciakötetConference proceedings32000Oltalmi formákProtection forms26000DisszertációThesis28000EgyébMiscellaneous29000AlkotásAchievement22000Kutatási adatResearch data33000201801111201904444202002222202105555202200000202302222Q2falsefalsefalsefalse2019-01-31T22:59:00.000+00002018-04-08T23:57:02.000+0000Farmakológiai Kutatócsoport (KOKI / GYO); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO)28260trueLanguage10002
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Rakovska, A </span> <span class="author-type"> </span> ; <span class="author-name" mtid="91"> <a href="/gui2/?type=authors&mode=browse&sel=91" target="_blank">Baranyi, M</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="81"> <a href="/gui2/?type=authors&mode=browse&sel=81" target="_blank">Windisch, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Petkova-Kirova, P </span> <span class="author-type"> </span> ; <span class="author-name" > Gagov, H </span> <span class="author-type"> </span> ; <span class="author-name" > Kalfin, R </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3356697" mtid="3356697" target="_blank">Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.</a></div> <div class="pub-info"> <span class="journal-title">BRAIN RESEARCH BULLETIN</span> <span class="journal-volume">134</span> <span class="page"> pp. 246-252. , 7 p. </span> <span class="year">(2017)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/j.brainresbull.2017.08.005" target="_blank" href="https://doi.org/10.1016/j.brainresbull.2017.08.005"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000411847400032" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000411847400032"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85028453774" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85028453774"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="28802898" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28802898&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3356697 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 14 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 14 | Scopus jelölt: 14 | WoS/Scopus jelölt: 14 | DOI jelölt: 14 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;3356697" target="_blank">Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.</a></div> <div> <span class="journal-title">BRAIN RESEARCH BULLETIN</span>
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span>
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Forrás Idéző
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<div class="lastModified">Utolsó módosítás: 2021.03.31. 09:07 Turek Márta (KOKI admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Lab. “Neuropeptide”, Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 23, Sofia, 1113, Bulgaria
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest, H-1083, Hungary
Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences...</pre>
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