https://m2.mtmt.hu/ eng 2026-05-25 07:44 JournalArticle 33555063 VALIDATED true Institute of Translational Medicine, Semmelweis University, Budapest, 1094, Hungary Eötvös Loránd Research Network, Semmelweis University (ELKH-SU), Cerebrovascular and Neurocognitive Disorders Research Group, Budapest, 1094, Hungary Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, OK, United States Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Departments of Public Health and Translational Medicine, Semmelweis University, Budapest, 1085, Hungary The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, OK, United States Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1082, Hungary Workgroup for Science Management, Semmelweis University, Budapest, 1085, Hungary Export Date: 20 May 2025; Cited By: 53; Correspondence Address: É. Pál; Institute of Translational Medicine, Semmelweis University, Budapest, 1094, Hungary; email: pal.eva@med.semmelweis-univ.hu 0 false 2026-05-22T15:43:27.994+0000 2025-05-06T08:41:22.979+0000 2023-01-11T14:52:40.675+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-04-20T10:04:46.487+0000 2025-05-06T08:41:23.391+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Pál, Éva Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 15 2 334 334 25 2023 Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects approximately 24% to 40% of the population of the Western world. In addition to its well-documented effects on the musculoskeletal system, VitD also contributes importantly to the promotion and preservation of cardiovascular health via modulating the immune and inflammatory functions and regulating cell proliferation and migration, endothelial function, renin expression, and extracellular matrix homeostasis. This brief overview focuses on the cardiovascular and cerebrovascular effects of VitD and the cellular, molecular, and functional changes that occur in the circulatory system in VitD deficiency (VDD). It explores the links among VDD and adverse vascular remodeling, endothelial dysfunction, vascular inflammation, and increased risk for cardiovascular and cerebrovascular diseases. Improved understanding of the complex role of VDD in the pathogenesis of atherosclerotic cardiovascular diseases, stroke, and vascular cognitive impairment is crucial for all cardiologists, dietitians, and geriatricians, as VDD presents an easy target for intervention. 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(SE / AOK / I / TMI); Népegészségtani Intézet (SE / AOK / I); Szülészeti és Nőgyógyászati Klinika Üllői úti r... (SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (SE / AOK / I) 4 38 5 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106257180 /api/authorship/106257180 1 0.25 true false true Author 10056835 /api/author/10056835 Pál Éva true 10056835 true Pál Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106257181 /api/authorship/106257181 2 0.25 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvári Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106257182 /api/authorship/106257182 3 0.25 false true false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106257183 /api/authorship/106257183 4 0.25 false true false Author 10011316 /api/author/10011316 Várbíró Szabolcs true 10011316 true Várbíró Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22824090 /api/publicationidentifier/22824090 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/nu15020334 https://doi.org/10.3390/nu15020334 false true PublicationIdentifier 23140631 /api/publicationidentifier/23140631 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000916332100001 https://www.webofscience.com/wos/woscc/full-record/000916332100001 true true PublicationIdentifier 22992902 /api/publicationidentifier/22992902 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85146812454 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146812454 false true PublicationIdentifier 23038529 /api/publicationidentifier/23038529 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36678205 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36678205&dopt=Abstract false true PublicationIdentifier 31511442 /api/publicationidentifier/31511442 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/2072-6643/15/2/334 https://www.mdpi.com/2072-6643/15/2/334 false true SjrRating 11379425 /api/sjrrating/11379425 22 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true D1 DIRECT true true /api/publication/33555063 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10056835"><a href="/gui2/?type=authors&mode=browse&sel=10056835" target="_blank">Pál Éva ✉ (<span class="authorship-author-name">Pál Éva</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SU Cerebrovascular and Neurocognitive Diseases Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvári Zoltán (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán<sup>**</sup> (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SU Cerebrovascular and Neurocognitive Diseases Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33555063" target="_blank">Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">2</span> <span class="page"> Paper 334. 25 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nu15020334" target="_blank" href="https://doi.org/10.3390/nu15020334"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000916332100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000916332100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85146812454" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146812454"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36678205" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36678205&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/2072-6643/15/2/334" target="_blank" href="https://www.mdpi.com/2072-6643/15/2/334"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Food Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 99</span> | Independent citation: 95 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 79 | Number of citations in Scopus:&nbsp;80 | WoS/Scopus assigned:&nbsp;88 | Number of citations with DOI:&nbsp;99 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33555063&sort=publishedYear,desc&sort=title"> Number of cited publications: 34 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33555063</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (STIA-KFI-2021), (STIA-OTKA-2021), (2020-1.1.6-JÖVŐ-2021-00010), (2020-1.1.6-JOVO-2021-00013), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Funder: NRDIO, (TKP2021-EGA-25), (TKP2021-NKTA-47), (ÚNKP-22-4-II-SE-17), (K-139230) Funder: NRDIO, (K-125174) Funder: HSRF, (PD-143327) </div> <div class="lastModified">Last Modified: 2025.05.06. 10:41 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Translational Medicine, Semmelweis University, Budapest, 1094, Hungary Eötvös Loránd Research Network, Semmelweis University (ELKH-SU), Cerebrovascular and Neurocognitive Disorders Research Group, Budapest, 1094, Hungary Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Agin...</pre> </div></div>