https://m2.mtmt.hu/ eng 2026-06-25 14:26 JournalArticle 33552513 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office [K132393, FK132474, FK134267]; Ministry of Innovation and Technology [TKP2021-EGA-25, UNKP-19-3-IV-SE-3]; Deutsche Forschungsgemeinschaft [TRR186] Funding text: National Research, Development and Innovation Office K132393 Krisztina Kaldir National Research, Development and Innovation Office FK132474 Norbert Gyongyosir National Research, Development and Innovation Office FK134267 Orsolya Kapuyr Ministry of Innovation and Technology TKP2021-EGA-25 Krisztina Kaldir Ministry of Innovation and Technology UNKP-19-3-IV-SE-3 Anita Szoker Deutsche Forschungsgemeinschaft TRR186 Michael Brunner 0 false 2026-05-22T15:40:55.997+0000 2026-04-08T13:14:01.982+0000 2023-01-11T07:10:05.422+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-04-08T13:14:01.875+0000 2024-07-25T07:37:25.124+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szőke, Anita Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa. true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 12 e79765 e79765 26 2023 The circadian clock governs rhythmic cellular functions by driving the expression of a substantial fraction of the genome and thereby significantly contributes to the adaptation to changing environmental conditions. Using the circadian model organism Neurospora crassa, we show that molecular timekeeping is robust even under severe limitation of carbon sources, however, stoichiometry, phosphorylation and subcellular distribution of the key clock components display drastic alterations. Protein kinase A, protein phosphatase 2 A and glycogen synthase kinase are involved in the molecular reorganization of the clock. RNA-seq analysis reveals that the transcriptomic response of metabolism to starvation is highly dependent on the positive clock component WC-1. Moreover, our molecular and phenotypic data indicate that a functional clock facilitates recovery from starvation. We suggest that the molecular clock is a flexible network that allows the organism to maintain rhythmic physiology and preserve fitness even under long-term nutritional stress. Funding 2042487 /api/funding/2042487 false true Funding 2042488 /api/funding/2042488 false true Funding 2042489 /api/funding/2042489 false true Funding 2042490 /api/funding/2042490 false true Funding 2042491 /api/funding/2042491 false true 2023 true true true false true false GOLD 2026-05-22 true https://doi.org/10.7554/eLife.79765 3 0 3 2 0 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 6 6 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 0 0 0 0 2025 0 1 0 1 0 D1 false 10023423,10009913 false false false 2023-01-15T11:56:45.209+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Élettani Intézet (SE / AOK / I) 5 11 2 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106245327 /api/authorship/106245327 1 0.125 true false false Author 10060609 /api/author/10060609 Szőke Anita true 10060609 true Szőke Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245328 /api/authorship/106245328 2 0.125 false false false Author 10074006 /api/author/10074006 Sárkány Orsolya true true Sárkány Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245329 /api/authorship/106245329 3 0.125 false false false Schermann Géza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245330 /api/authorship/106245330 4 0.125 false false false Author 10026330 /api/author/10026330 Kapuy Orsolya true 10026330 true Kapuy Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245331 /api/authorship/106245331 5 0.125 false false false Diernfellner Axel C R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245332 /api/authorship/106245332 6 0.125 false false false Brunner Michael true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245333 /api/authorship/106245333 7 0.125 false true false Author 10023423 /api/author/10023423 Gyöngyösi Norbert true 10023423 true Gyöngyösi Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106245334 /api/authorship/106245334 8 0.125 false true true Author 10009913 /api/author/10009913 Káldi Krisztina true 10009913 true Káldi Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22817686 /api/publicationidentifier/22817686 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.7554/eLife.79765 https://doi.org/10.7554/eLife.79765 false true PublicationIdentifier 23243244 /api/publicationidentifier/23243244 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000933104100001 https://www.webofscience.com/wos/woscc/full-record/000933104100001 true true PublicationIdentifier 22852927 /api/publicationidentifier/22852927 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85145957354 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85145957354 true true PublicationIdentifier 22817685 /api/publicationidentifier/22817685 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36625037 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36625037&dopt=Abstract false true Classification 12124 /api/classification/12124 true true Keyword 4354 /api/keyword/4354 true 4354 true Keyword 5963 /api/keyword/5963 true 5963 true Keyword 7975 /api/keyword/7975 true 7975 true Keyword 16494 /api/keyword/16494 true 16494 true Keyword 1027454 /api/keyword/1027454 true 1027454 true Keyword 1034819 /api/keyword/1034819 true 1034819 true Keyword 1037334 /api/keyword/1037334 true 1037334 true Keyword 1200071 /api/keyword/1200071 true 1200071 true Keyword 1236369 /api/keyword/1236369 true 1236369 true Keyword 1789457 /api/keyword/1789457 true true Keyword 2956279 /api/keyword/2956279 true true SjrRating 11358157 /api/sjrrating/11358157 16 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true D1 DIRECT true true /api/publication/33552513 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060609"><a href="/gui2/?type=authors&mode=browse&sel=10060609" target="_blank">Szőke Anita (<span class="authorship-author-name">Szőke Anita</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074006"><a href="/gui2/?type=authors&mode=browse&sel=10074006" target="_blank">Sárkány Orsolya (<span class="authorship-author-name">Sárkány Orsolya</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schermann Géza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy Orsolya (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diernfellner Axel C R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brunner Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023423"><a href="/gui2/?type=authors&mode=browse&sel=10023423" target="_blank">Gyöngyösi Norbert<sup>**</sup> (<span class="authorship-author-name">Gyöngyösi Norbert</span> <span class="authorAux-mtmt"> cirkadián ritmusok, alvás-ébrenlét szabályozása...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009913"><a href="/gui2/?type=authors&mode=browse&sel=10009913" target="_blank">Káldi Krisztina ✉ (<span class="authorship-author-name">Káldi Krisztina</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33552513" target="_blank">Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa.</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper e79765. 26 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.79765" target="_blank" href="https://doi.org/10.7554/eLife.79765"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000933104100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000933104100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85145957354" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85145957354"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36625037" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36625037&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 3</span> | Independent citation: 2 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 3 | Number of citations in Scopus:&nbsp;3 | WoS/Scopus assigned:&nbsp;3 | Number of citations with DOI:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33552513&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33552513</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (K 132393), (FK 132474), (FK-134267), (TKP2021-EGA-25), (ÚNKP-19-3-IV-SE-3) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2026.04.08. 15:14 Kinga Sonnevend (SE_AOK_Élettan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office [K132393, FK132474, FK134267]; Ministry of Innovation and Technology [TKP2021-EGA-25, UNKP-19-3-IV-SE-3]; Deutsche Forschungsgemeinschaft [TRR186] Funding text: National Research, Development and Innovation Office K132393 Krisztina Kaldir National Research, Development and Innovation Office FK13247...</pre> </div></div>