https://m2.mtmt.hu/ hun 2026-09-22 02:41 JournalArticle 33550141 APPROVED true 0 false 2026-06-05T11:36:18.203+0000 2026-06-05T11:23:13.172+0000 2023-01-10T08:28:20.853+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-06-05T11:23:14.380+0000 2026-06-05T11:23:14.380+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Stylianou, O. Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment true true /api/journal/20064447 REVIEWED true false false 20064447 true 2504-3110 Journal FOREIGN 6 12 737 737 13 2022 Dopaminergic treatment (DT), the standard therapy for Parkinson's disease (PD), alters the dynamics of functional brain networks at specific time scales. Here, we explore the scale-free functional connectivity (FC) in the PD population and how it is affected by DT. We analyzed the electroencephalogram of: (i) 15 PD patients during DT (ON) and after DT washout (OFF) and (ii) 16 healthy control individuals (HC). We estimated FC using bivariate focus-based multifractal analysis, which evaluated the long-term memory (H(2)) and multifractal strength (ΔH15) of the connections. Subsequent analysis yielded network metrics (node degree, clustering coefficient and path length) based on FC estimated by H(2) or ΔH15. Cognitive performance was assessed by the Mini Mental State Examination (MMSE) and the North American Adult Reading Test (NAART). The node degrees of the ΔH15 networks were significantly higher in ON, compared to OFF and HC, while clustering coefficient and path length significantly decreased. No alterations were observed in the H(2) networks. Significant positive correlations were also found between the metrics of H(2) networks and NAART scores in the HC group. These results demonstrate that DT alters the multifractal coupled dynamics in the brain, warranting the investigation of scale-free FC in clinical and pharmacological studies. true 2023 true true true false true false GOLD 2026-06-05 true https://doi.org/10.3390/fractalfract6120737 11 0 11 8 2 11 11 11 10 11 11 8 8 8 3 0 11 8 11 8 0 5 5 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 2 2 2 2024 0 3 1 3 1 2025 0 4 3 4 3 2026 0 2 2 2 2 Q2 false 10024096 false false false 2023-01-09T08:38:05.867+0000 Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 6 12 2 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106234919 /api/authorship/106234919 1 0.111 true false false Author 10071680 /api/author/10071680 Stylianou Orestis true true Stylianou O. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234920 /api/authorship/106234920 2 0.111 false false false Author 10081142 /api/author/10081142 Káposzta Zalán true true Káposzta Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234921 /api/authorship/106234921 3 0.111 false false false Author 10081139 /api/author/10081139 Czoch Ákos true true Czoch Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234922 /api/authorship/106234922 4 0.11111111 false false false Stefanovski L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234923 /api/authorship/106234923 5 0.11111111 false false false Yabluchanskiy A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234924 /api/authorship/106234924 6 0.111 false false false Author 10059431 /api/author/10059431 Rácz Frigyes Sámuel true 10059431 true Rácz F.S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234925 /api/authorship/106234925 7 0.11111111 false false false Ritter P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234926 /api/authorship/106234926 8 0.111 false false true Author 10024096 /api/author/10024096 Eke András true 10024096 true Eke A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106234927 /api/authorship/106234927 9 0.111 false true true Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22811727 /api/publicationidentifier/22811727 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/fractalfract6120737 https://doi.org/10.3390/fractalfract6120737 false true PublicationIdentifier 22871188 /api/publicationidentifier/22871188 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000902553900001 https://www.webofscience.com/wos/woscc/full-record/000902553900001 true true PublicationIdentifier 22811726 /api/publicationidentifier/22811726 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85144679384 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85144679384 false true PublicationIdentifier 29500490 /api/publicationidentifier/29500490 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38106971 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38106971&dopt=Abstract true true Classification 11608 /api/classification/11608 true true SjrRating 11307054 /api/sjrrating/11307054 61 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2603 /api/classificationexternal/2603 true 2603 true Q2 DIRECT true true /api/publication/33550141 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071680"><a href="/gui2/?type=authors&mode=browse&sel=10071680" target="_blank">Stylianou O. (<span class="authorship-author-name">Stylianou Orestis</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081142"><a href="/gui2/?type=authors&mode=browse&sel=10081142" target="_blank">Káposzta Z. (<span class="authorship-author-name">Káposzta Zalán</span> <span class="authorAux-mtmt"> Fraktálélettan és Hálózatelméleti Analízis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081139"><a href="/gui2/?type=authors&mode=browse&sel=10081139" target="_blank">Czoch Á. (<span class="authorship-author-name">Czoch Ákos</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stefanovski L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059431"><a href="/gui2/?type=authors&mode=browse&sel=10059431" target="_blank">Rácz F.S. (<span class="authorship-author-name">Rácz Frigyes Sámuel</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ritter P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024096"><a href="/gui2/?type=authors&mode=browse&sel=10024096" target="_blank">Eke A. ✉ (<span class="authorship-author-name">Eke András</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli P. ✉ (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33550141" target="_blank">Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment</a></div> <div> <span class="journal-title">FRACTAL AND FRACTIONAL</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2504-3110">2504-3110</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">12</span> <span class="page"> Paper 737. 13 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/fractalfract6120737" target="_blank" href="https://doi.org/10.3390/fractalfract6120737"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000902553900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000902553900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85144679384" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85144679384"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38106971" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38106971&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Statistical and Nonlinear Physics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Statistics and Probability&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 8 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33550141&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33550141</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.05. 13:23 Sonnevend Kinga (SE_AOK_Élettan_Admin5_SK, admin) </div> </div></div>