https://m2.mtmt.hu/ hun 2026-10-25 12:42 JournalArticle 3354869 VALIDATED true WoS:hiba:000427081800004 2019-11-12 23:53 első szerző nem egyezik 0 2018-07-02T22:25:37.000+0000 false 3354869 2026-10-18T17:01:34.435+0000 2023-10-24T12:43:15.364+0000 2018-04-03T11:53:45.000+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin Patkósné Hanesz Andrea (SZBK-4-es admin) true 10045852 2023-10-24T12:43:15.630+0000 2023-10-24T12:43:15.630+0000 2019-12-18T07:40:59.634+0000 true 10013822 WoS admin-2 -1 /api/admin/10013822 Admin WoS admin-2 -1 (WoS import 3, admin) true 10013822 2019-12-18T07:41:58.851+0000 true 10013822 WoS admin-2 -1 /api/admin/10013822 Admin WoS admin-2 -1 (WoS import 3, admin) true 10013822 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Villegas, SN true true /api/journal/10022692 REVIEWED CELL REPORTS 2639-1856 2211-1247 true false 10022692 false 10022692 true 2639-1856 2211-1247 Journal FOREIGN 22 10 2541 2549 2541 9 2018 The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to develop drugs with fewer side effects than those currently available. Here, using an unbiased in vivo chemical genetic screen in Drosophila, we identified compounds that inhibit the activity of proinflammatory enzymes nitric oxide synthase (NOS) and lipoxygenase (LOX) as selective suppressors of Notch-PI3K/Akt cooperative oncogenesis. Tumor silencing of NOS and LOX signaling mirrored the antitumor effect of the hit compounds, demonstrating their participation in Notch-PI3K/Akt- induced tumorigenesis. Oncogenic PI3K/Akt signaling triggered inflammation and immunosuppression via aberrant NOS expression. Accordingly, activated Notch tumorigenesis was fueled by hampering the immune response or by NOS overexpression to mimic a protumorigenic environment. Our lead compound, the LOX inhibitor BW B70C, also selectively killed human leukemic cells by dampening the NOTCH1-PI3K/AKT-eNOS axis. 2018 (Patkósné Hanesz Andrea (SZBK-4-es admin); 2018.04.03. 13:46:55) true true true false true false GOLD 2026-10-18 true https://doi.org/10.1016/j.celrep.2018.02.049 81 1 81 78 0 81 81 76 67 81 81 78 78 78 3 0 81 78 81 78 0 0 0 Folyóiratcikk Journal Article 24 80 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2018 0 2 2 2 2 2019 0 11 10 11 10 2020 0 8 8 8 8 2021 0 16 15 16 15 2022 0 9 9 9 9 2023 0 9 9 9 9 2024 0 17 16 17 16 2025 0 7 7 7 7 2026 0 2 2 2 2 D1 false false false false 2018-04-03T12:45:54.000+0000 2018-04-03T12:45:50.000+0000 Genetikai Intézet (HRN SZBK); MTA-SZBK-NAP B Axon növekedés és regeneráció ku... (HRN SZBK / GI) 2 11 2 10 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 9967222 /api/authorship/9967222 Villegas, SN 1 0.1 true false Villegas SN true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002084 true PersonAuthorship 9967223 /api/authorship/9967223 Gombos, R [Gombos, Rita I (Genetika), szerző] Genetikai Intézet (HRN SZBK) 2 0.1 false false Author 10024995 /api/author/10024995 Gombos Rita I (Genetika) Gombos Rita I true 10024995 true Gombos R true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002083 true PersonAuthorship 9967224 /api/authorship/9967224 Garcia-Lopez, L 3 0.1 false false Garcia-Lopez L true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002082 true PersonAuthorship 9967225 /api/authorship/9967225 Gutierrez-Perez, I 4 0.1 false false Gutierrez-Perez I true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002081 true PersonAuthorship 9967226 /api/authorship/9967226 Garcia-Castillo, J 5 0.1 false false Garcia-Castillo J true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002080 true PersonAuthorship 9967227 /api/authorship/9967227 Vallejo, DM 6 0.1 false false Vallejo DM true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002079 true PersonAuthorship 9967228 /api/authorship/9967228 Da, Ros VG 7 0.1 false false Da Ros VG true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002078 true PersonAuthorship 9967229 /api/authorship/9967229 Ballesta-Illan, E 8 0.1 false false Ballesta-Illan E true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002077 true PersonAuthorship 9967230 /api/authorship/9967230 Mihaly, J [Mihály, József (genetika), szerző] MTA-SZBK-NAP B Axon növekedés és regeneráció ku... (HRN SZBK / GI) 9 0.1 false false Author 10010519 /api/author/10010519 Mihály József (genetika) Mihály József true 10010519 true Mihaly J true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002076 true PersonAuthorship 9967231 /api/authorship/9967231 Dominguez, M 10 0.1 false true Dominguez M true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 28002075 true PublicationIdentifier 1287218 /api/publicationidentifier/1287218 DOI: 10.1016/j.celrep.2018.02.049 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true NO 10.1016/j.celrep.2018.02.049 https://doi.org/10.1016/j.celrep.2018.02.049 false 1750421 true PublicationIdentifier 1287217 /api/publicationidentifier/1287217 WoS: 000427081800004 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000427081800004 https://www.webofscience.com/wos/woscc/full-record/000427081800004 false 1750420 true PublicationIdentifier 24560722 /api/publicationidentifier/24560722 Scopus: 85043387436 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 85043387436 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85043387436 false true PublicationIdentifier 1287219 /api/publicationidentifier/1287219 PubMed: 29514083 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 29514083 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29514083&dopt=Abstract false 1750422 true Classification 10545 /api/classification/10545 Biológiai tudományok true true SjrRating 10751783 /api/sjrrating/10751783 sjr:D1 (2018) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELL REPORTS 2211-1247 8 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true D1 DIRECT true true Reference 2305193 /api/reference/2305193 1. 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(2018) CELL REPORTS 2639-1856 2211-1247 22 10 2541-2549<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Villegas SN </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024995"><a href="/gui2/?type=authors&mode=browse&sel=10024995" target="_blank">Gombos R (<span class="authorship-author-name">Gombos Rita I</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Lopez L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gutierrez-Perez I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Castillo J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vallejo DM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Da Ros VG </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ballesta-Illan E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihaly J (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/<span title="Genetikai Intézet">GI</span>/MTA-SZBK-NAP B Axon növekedés és regeneráció kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dominguez M </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3354869" target="_blank">PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation</a></div> <div> <span class="journal-title">CELL REPORTS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2639-1856">2639-1856</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2211-1247">2211-1247</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">10</span> <span class="page"> pp 2541-2549 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="10.1016/j.celrep.2018.02.049" target="_blank" href="https://doi.org/10.1016/j.celrep.2018.02.049"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000427081800004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000427081800004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85043387436" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85043387436"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="29514083" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29514083&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 81</span> | Független: 78 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 76 | Scopus jelölt:&nbsp;67 | WoS/Scopus jelölt:&nbsp;81 | DOI jelölt:&nbsp;81 (Nem nyilvános:&nbsp;1) </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3354869</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3354869</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2023.10.24. 14:43 Patkósné Hanesz Andrea (SZBK-4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: WoS:hiba:000427081800004 2019-11-12 23:53 első szerző nem egyezik</pre> </div></div>