https://m2.mtmt.hu/ eng 2026-05-01 18:18 JournalArticle 33543493 VALIDATED true 0 false 2026-04-29T13:11:29.759+0000 2025-06-06T08:02:23.594+0000 2023-01-06T05:37:03.850+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-04-29T06:04:54.379+0000 2024-04-15T09:47:05.680+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2024-01-18T08:31:41.494+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vas, Szilvia Prolactin-releasing peptide contributes to stress-related mood disorders and inhibits sleep/mood regulatory melanin-concentrating hormone neurons in rats. true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 43 5 846 862 846 17 2023 Stress disorders impair sleep, quality of life, however, their pathomechanisms are unknown. Prolactin-releasing peptide (PrRP) is a stress mediator, therefore, we hypothesised that PrRP may be involved in the development of stress disorders. PrRP is produced by the medullary A1/A2 noradrenaline (NA) cells, which transmit stress signals to forebrain centers, and by non-NA cells in the hypothalamic dorsomedial nucleus. We found in male rats that both PrRP and PrRP-NA cells innervate melanin-concentrating hormone (MCH) producing neurons in the dorsolateral hypothalamus (DLH). These cells serve as a key hub for regulating sleep and affective states. Ex vivo, PrRP hyperpolarized MCH neurons and further increased the hyperpolarization caused by NA. Following sleep deprivation, intracerebroventricular PrRP injection reduced the number of REM sleep-active MCH cells. PrRP expression in the dorsomedial nucleus was up-regulated by sleep deprivation, while down-regulated by REM sleep rebound. Both in learned helplessness paradigm and after peripheral inflammation, impaired coping with sustained stress was associated with (i) overactivation of PrRP cells, (ii) PrRP protein and receptor depletion in the DLH, and (iii) dysregulation of MCH expression. Exposure to stress in PrRP insensitive period led to increased passive coping with stress. Normal PrRP signaling, therefore, seems to protect animals against stress-related disorders. PrRP signaling in the DLH is important component of the PrRP's action, which may be mediated by MCH neurons. Moreover, PrRP receptors were downregulated in the DLH of human suicidal victims. As stress-related mental disorders are the leading cause of suicide, our findings may have particular translational relevance.SIGNIFICANCE STATEMENT:Treatment resistance to monoaminergic antidepressants is a major problem. Neuropeptides that modulate the central monoaminergic signaling are promising targets for developing alternative therapeutic strategies. We found that stress-responsive prolactin-releasing peptide (PrRP) cells innervated melanin-concentrating hormone (MCH) neurons that are crucial in the regulation of sleep and mood. PrRP inhibited MCH cell activity and enhanced the inhibitory effect evoked by noradrenaline, a classic monoamine, on MCH neurons. We observed that impaired PrRP signaling led to failure in coping with chronic/repeated stress and was associated with altered MCH expression. We found alterations of the PrRP system also in suicidal human subjects. PrRP dysfunction may underlie stress disorders, and fine-tuning MCH activity by PrRP may be an important part of the mechanism. Funding 2023383 /api/funding/2023383 false true Funding 2033279 /api/funding/2033279 false true Funding 2033280 /api/funding/2033280 false true Funding 2023382 /api/funding/2023382 false true Funding 2023384 /api/funding/2023384 false true Funding 2023385 /api/funding/2023385 false true true true 2023 true true true false true false GREEN 2026-04-29 true http://real.mtak.hu/160987 7 0 7 3 4 7 7 7 7 7 7 3 3 3 4 0 7 3 7 3 0 11 11 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 3 1 3 1 2026 0 1 0 1 0 Q1 false 10011497,10001325 false false false 2023-02-07T08:13:49.717+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Endokrin Neurobiológiai Kutatócsoport (HRN KOKI); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Gyógyszerhatástani Intézet (SE / GYTK); Humán Agyminta Bank (SE / AOK / I / ASZFI_2016); Kísérleti Orvostudományi Kutatóintézet; MTA-SE Neuropszichofarmakológiai és Neurokémiai... (SE / GYTK / GYHATAS); Magatartásélettan és Stressz Kutatócsoport (KOKI / MO); Molekuláris Neuroendokrinológiai Kutatócsoport (HRN KOKI); NAP-2-SE Új Antidepresszív Gyógyszercélpont Kut... (SE / GYTK / GYHATAS); Orálbiológiai Tanszék (SE / FOK); Reproduktív Neurobiológia Laboratórium (HRN KOKI); Szentágothai János Kutatóközpont (PTE); Élettani Intézet (PTE / ÁOK) 23 63 14 23 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 106196569 /api/authorship/106196569 1 0.043 true false false Author 10024146 /api/author/10024146 Vas Szilvia true 10024146 true Vas Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106196570 /api/authorship/106196570 2 0.043 false false false Author 10024761 /api/author/10024761 Papp Rege Sugárka true 10024761 true Papp Rege S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 106196571 /api/authorship/106196571 3 0.043 false false false Author 10024762 /api/author/10024762 Könczöl Katalin true 10024762 true Könczöl Katalin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024146"><a href="/gui2/?type=authors&mode=browse&sel=10024146" target="_blank">Vas Szilvia (<span class="authorship-author-name">Vas Szilvia</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024761"><a href="/gui2/?type=authors&mode=browse&sel=10024761" target="_blank">Papp Rege S (<span class="authorship-author-name">Papp Rege Sugárka</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024762"><a href="/gui2/?type=authors&mode=browse&sel=10024762" target="_blank">Könczöl Katalin (<span class="authorship-author-name">Könczöl Katalin</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045708"><a href="/gui2/?type=authors&mode=browse&sel=10045708" target="_blank">Bogáthy Emese (<span class="authorship-author-name">Bogáthy Emese</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055910"><a href="/gui2/?type=authors&mode=browse&sel=10055910" target="_blank">Papp Noémi (<span class="authorship-author-name">Papp Noémi</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034343"><a href="/gui2/?type=authors&mode=browse&sel=10034343" target="_blank">Ádori Csaba (<span class="authorship-author-name">Ádori Csaba</span> <span class="authorAux-mtmt"> Neuromorfológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051107"><a href="/gui2/?type=authors&mode=browse&sel=10051107" target="_blank">Durst Máté (<span class="authorship-author-name">Durst Máté</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072403"><a href="/gui2/?type=authors&mode=browse&sel=10072403" target="_blank">Sípos Klaudia (<span class="authorship-author-name">Sípos Klaudia</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074191"><a href="/gui2/?type=authors&mode=browse&sel=10074191" target="_blank">Ocskay Klementina (<span class="authorship-author-name">Ocskay Klementina</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011497"><a href="/gui2/?type=authors&mode=browse&sel=10011497" target="_blank">Farkas Imre (<span class="authorship-author-name">Farkas Imre</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Reproductive Neurobiology; <span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047829"><a href="/gui2/?type=authors&mode=browse&sel=10047829" target="_blank">Bálint Flóra (<span class="authorship-author-name">Bálint Flóra</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Endocrine Neurobiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013609"><a href="/gui2/?type=authors&mode=browse&sel=10013609" target="_blank">Ferenci Szilamér (<span class="authorship-author-name">Ferenczi Szilamér</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Neuroendocrinology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066202"><a href="/gui2/?type=authors&mode=browse&sel=10066202" target="_blank">Török Bibiána (<span class="authorship-author-name">Szocsics-Török Bibiána</span> <span class="authorAux-mtmt"> Biológus</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre; <span title="Institute of Experimental Medicine">IEM</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020538"><a href="/gui2/?type=authors&mode=browse&sel=10020538" target="_blank">Kovács Anita (<span class="authorship-author-name">Kovács Anita</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100730"><a href="/gui2/?type=authors&mode=browse&sel=10100730" target="_blank">Szabó Evelin (<span class="authorship-author-name">Szabó Evelin</span> <span class="authorAux-mtmt"> Idegtudomány, viselkedésfarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011471"><a href="/gui2/?type=authors&mode=browse&sel=10011471" target="_blank">Zelena Dóra (<span class="authorship-author-name">Zelena Dóra</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute of Physiology; <span title="University of Pécs">UP</span>/Szentágothai Research Centre; <span title="Institute of Experimental Medicine">IEM</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovács Krisztina J (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Molecular Neuroendocrinology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="105"><a href="/gui2/?type=authors&mode=browse&sel=105" target="_blank">Földes Anna (<span class="authorship-author-name">Földes Anna</span> <span class="authorAux-mtmt"> Molekulár biológia, Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015479"><a href="/gui2/?type=authors&mode=browse&sel=10015479" target="_blank">Kató Erzsébet (<span class="authorship-author-name">Kató Erzsébet</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015482"><a href="/gui2/?type=authors&mode=browse&sel=10015482" target="_blank">Köles László (<span class="authorship-author-name">Köles László</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Biology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy György (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/NAP-2-SE New Antidepressant Target Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000458"><a href="/gui2/?type=authors&mode=browse&sel=10000458" target="_blank">Palkovits Miklós (<span class="authorship-author-name">Palkovits Miklós</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Anatómiai, Szövet- és Fejlődéstani Intézet">ASZFI_2016</span>/Human Brain Tissue Bank</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001325"><a href="/gui2/?type=authors&mode=browse&sel=10001325" target="_blank">Tóth Zsuzsanna E ✉ (<span class="authorship-author-name">Tóth Zsuzsanna</span> <span class="authorAux-mtmt"> Neuromorfológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33543493" target="_blank">Prolactin-releasing peptide contributes to stress-related mood disorders and inhibits sleep/mood regulatory melanin-concentrating hormone neurons in rats.</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">43</span> <span class="journal-issue">5</span> <span class="page"> pp 846-862 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/JNEUROSCI.2139-21.2022" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.2139-21.2022"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="160987" target="_blank" href="http://real.mtak.hu/160987"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000939233800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000939233800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85147318085" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85147318085"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36564184" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36564184&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 3 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33543493&sort=publishedYear,desc&sort=title"> Number of cited publications: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33543493</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> Agykutatási Kiválósági Központok fejlesztése(KTIA_NAP_13-1-2013-0001) Funder: NRDIO, Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), National Development Agency Grant(KTIA_NAP_13-1-2013-0001), (KTIA_13_NAPA-II/14), NKFIH(K 115422,), (TKP2021-EGA-25) </div> <div class="lastModified">Last Modified: 2025.06.06. 10:02 Róbert Milánkovics (PTE ÁOK admin 4) </div> <div class="lockedBy">Centrally managed 2024.01.18. 09:31 György Wolf (MTMT Központi admin) </div> </div></div>