https://m2.mtmt.hu/ hun 2026-09-21 03:17 JournalArticle 33541689 VALIDATED true Department of Molecular Biology, Semmelweis University, Budapest, 1094, Hungary MTA-SE Pathobiochemistry Research Group, Semmelweis University, Budapest, 1094, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1089, Hungary HCEMM-SU Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, 1085, Hungary IQVIA Hungary, Budapest, 1117, Hungary Cited By :2 Export Date: 24 August 2024 Correspondence Address: Varga, A.; Department of Molecular Biology, Hungary; email: varga.attila@med.semmelweis-univ.hu Correspondence Address: Sőti, C.; Department of Molecular Biology, Hungary; email: soti.csaba@med.semmelweis-univ.hu 0 false 2026-09-14T16:34:42.948+0000 2024-05-30T12:05:26.227+0000 2023-01-04T20:16:05.639+0000 true 10000786 Csala Miklós /api/author/10000786 Author Csala Miklós (Biokémia) true 10000786 2026-06-02T07:42:25.133+0000 2026-06-02T07:42:25.133+0000 2024-05-30T12:05:26.448+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Varga, Attila true true /api/journal/10051562 REVIEWED CELLS 2073-4409 true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 12 2 212 212 15 2023 Prostate cancer metastasis is a significant cause of mortality in men. PKD3 facilitates tumor growth and metastasis, however, its regulation is largely unclear. The Hsp90 chaperone stabilizes an array of signaling client proteins, thus is an enabler of the malignant phenotype. Here, using different prostate cancer cell lines, we report that Hsp90 ensures PKD3 conformational stability and function to promote cancer cell migration. We found that pharmacological inhibition of either PKDs or Hsp90 dose-dependently abrogated the migration of DU145 and PC3 metastatic prostate cancer cells. Hsp90 inhibition by ganetespib caused a dose-dependent depletion of PKD2, PKD3, and Akt, which are all involved in metastasis formation. Proximity ligation assay and immunoprecipitation experiments demonstrated a physical interaction between Hsp90 and PKD3. Inhibition of the chaperone–client interaction induced misfolding and proteasomal degradation of PKD3. PKD3 siRNA combined with ganetespib treatment demonstrated a specific involvement of PKD3 in DU145 and PC3 cell migration, which was entirely dependent on Hsp90. Finally, ectopic expression of PKD3 enhanced migration of non-metastatic LNCaP cells in an Hsp90-dependent manner. Altogether, our findings identify PKD3 as an Hsp90 client and uncover a potential mechanism of Hsp90 in prostate cancer metastasis. The molecular interaction revealed here may regulate other biological and pathological functions. Funding 2023250 /api/funding/2023250 (K 124813) Támogató: NKFIH false true Funding 2023251 /api/funding/2023251 (OTKA K116525) Támogató: NKFI false true Funding 2023252 /api/funding/2023252 (K131458) false true Funding 2023253 /api/funding/2023253 (TKP2021-EGA-24) false true true 2023 true true true false true false GOLD 2026-09-14 true https://doi.org/10.3390/cells12020212 8 0 8 8 0 8 8 8 7 8 8 8 8 8 0 0 8 8 8 8 0 3 3 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 4 4 4 4 2026 0 2 2 2 2 Q1 false 10047778,10059086,10000786,10076784 false false false 2023-02-07T09:20:06.387+0000 Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I); HCEMM-SE Molekuláris Onkohematológiai Kutatócso... (SE / AOK / I / PKRI); MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Orvosi Mikrobiológiai Intézet (SE / AOK / I) 11 20 5 11 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 106185297 /api/authorship/106185297 Varga, Attila ✉ [Varga, Attila (molekuláris biológia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.091 true false true Author 10040840 /api/author/10040840 Varga Attila (molekuláris biológia) Varga Attila true 10040840 true Varga Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185298 /api/authorship/106185298 Nguyen, Minh Tu [Nguyen, Minh Tu (biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 0.091 false false false Author 10030308 /api/author/10030308 Nguyen Minh Tu (biokémia, molekuláris biológia) Nguyen Minh Tu true 10030308 true Nguyen Minh Tu true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185299 /api/authorship/106185299 Pénzes, Kinga [Pénzes, Kinga (sejtbiológia, bio...), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Orvosi Mikrobiológiai Intézet (SE / AOK / I); Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 3 0.091 false false false Author 10044963 /api/author/10044963 Pénzes Kinga (sejtbiológia, biokémia) Pénzes Kinga true 10044963 true Pénzes Kinga true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185300 /api/authorship/106185300 Bátai, Bence [Bátai, Bence (Onkohematológia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); HCEMM-SE Molekuláris Onkohematológiai Kutatócso... (SE / AOK / I / PKRI) 4 0.091 false false false Author 10076784 /api/author/10076784 Bátai Bence (Onkohematológia) Bátai Bence true true Bátai Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185301 /api/authorship/106185301 Gyulavári, Pál [Gyulavári, Pál (Biokémia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 5 0.091 false false false Author 10028916 /api/author/10028916 Gyulavári Pál (Biokémia) Gyulavári Pál true 10028916 true Gyulavári Pál true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185302 /api/authorship/106185302 Gurbi, Bianka [Gurbi, Bianka (célzott daganatte...), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 6 0.091 false false false Author 10059086 /api/author/10059086 Gurbi Bianka (célzott daganatterápia) Gurbi Bianka true 10059086 true Gurbi Bianka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185303 /api/authorship/106185303 Murányi, József [Murányi, József (Biokémia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 7 0.091 false false false Author 10047778 /api/author/10047778 Murányi József (Biokémia) Murányi József true 10047778 true Murányi József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185304 /api/authorship/106185304 Csermely, Péter [Csermely, Péter (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 8 0.091 false false false Author 1035707 /api/author/1035707 Csermely Péter (Biokémia) Csermely Péter true 1035707 true Csermely Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185305 /api/authorship/106185305 Csala, Miklós [Csala, Miklós (Biokémia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 9 0.091 false false false Author 10000786 /api/author/10000786 Csala Miklós (Biokémia) Csala Miklós true 10000786 true Csala Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185306 /api/authorship/106185306 Vántus, Tibor [Vántus, Tibor (Biokémia), szerző] MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Biokémiai és Molekuláris Biológiai Intézet (SE / AOK / I) 10 0.091 false false false Author 10009602 /api/author/10009602 Vántus Tibor (Biokémia) Vántus Tibor true 10009602 true Vántus Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 106185307 /api/authorship/106185307 Sőti, Csaba ✉ [Sőti, Csaba (Biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 11 0.091 false true true Author 10012506 /api/author/10012506 Sőti Csaba (Biokémia, molekuláris biológia) Sőti Csaba true 10012506 true Sőti Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 22792367 /api/publicationidentifier/22792367 DOI: 10.3390/cells12020212 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cells12020212 https://doi.org/10.3390/cells12020212 false true PublicationIdentifier 23180784 /api/publicationidentifier/23180784 WoS: 000916995200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000916995200001 https://www.webofscience.com/wos/woscc/full-record/000916995200001 true true PublicationIdentifier 23044793 /api/publicationidentifier/23044793 Scopus: 85146784516 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85146784516 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146784516 true true PublicationIdentifier 23044794 /api/publicationidentifier/23044794 PubMed: 36672148 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36672148 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36672148&dopt=Abstract true true SjrRating 11358179 /api/sjrrating/11358179 sjr:Q1 (2023) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELLS 2073-4409 43 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q1 DIRECT true true Reference 37066581 /api/reference/37066581 1. Sharifi 2005: Androgen deprivation therapy for prostate cancer., JAMA, 294, p. 238, DOI: 10.1001/jama.294.2.238 1 10.1001/jama.294.2.238 false true Reference 37066582 /api/reference/37066582 2. Sharifi 2005: A retrospective study of the time to clinical endpoints for advanced prostate cancer., BJU Int., 96, p. 985, DOI: 10.1111/j.1464-410X.2005.05798.x 2 10.1111/j.1464-410X.2005.05798.x false true Reference 37066583 /api/reference/37066583 3. Siegel 2022: Cancer statistics, 2022., CA Cancer J. Clin., 72, p. 7, DOI: 10.3322/caac.21708 3 10.3322/caac.21708 false true Reference 37066584 /api/reference/37066584 4. Chaves, L.P., Melo, C.M., Saggioro, F.P., Reis, R.B.D., and Squire, J.A. (2021). Epithelial-Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision Therapeutics. Genes, 12., DOI: 10.3390/genes12121900 4 10.3390/genes12121900 false true Reference 37066585 /api/reference/37066585 5. Valverde 1994: Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain., Proc. Natl. Acad. Sci. USA, 91, p. 8572, DOI: 10.1073/pnas.91.18.8572 5 10.1073/pnas.91.18.8572 false true Reference 37066586 /api/reference/37066586 6. Sturany 2001: Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases., J. Biol. Chem., 276, p. 3310, DOI: 10.1074/jbc.M008719200 6 10.1074/jbc.M008719200 false true Reference 37066587 /api/reference/37066587 7. Hayashi 1999: PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu., Biochim. Biophys. Acta, 1450, p. 99, DOI: 10.1016/S0167-4889(99)00040-3 7 10.1016/S0167-4889(99)00040-3 false true Reference 37066588 /api/reference/37066588 8. Higuero 2006: Protein kinase D intracellular localization and activity control kinase D-interacting substrate of 220-kDa traffic through a postsynaptic density-95/discs large/zonula occludens-1-binding motif., J. Biol. Chem., 281, p. 18888, DOI: 10.1074/jbc.M603044200 8 10.1074/jbc.M603044200 false true Reference 37066589 /api/reference/37066589 9. Zhang, X., Connelly, J., Chao, Y., and Wang, Q.J. (2021). Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases. Biomolecules, 11., DOI: 10.3390/biom11030483 9 10.3390/biom11030483 false true Reference 37066590 /api/reference/37066590 10. Doppler, H., Bastea, L.I., Borges, S., Spratley, S.J., Pearce, S.E., and Storz, P. (2014). Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration. PLoS ONE, 9., DOI: 10.1371/journal.pone.0098090 10 10.1371/journal.pone.0098090 false true Reference 37066591 /api/reference/37066591 11. Borges 2015: Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101., Mol. Cancer Ther., 14, p. 1306, DOI: 10.1158/1535-7163.MCT-14-0945 11 10.1158/1535-7163.MCT-14-0945 false true Reference 37066592 /api/reference/37066592 12. Chen 2008: Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2., Cancer Res., 68, p. 3844, DOI: 10.1158/0008-5472.CAN-07-5156 12 10.1158/0008-5472.CAN-07-5156 false true Reference 37066593 /api/reference/37066593 13. Li 2019: Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells., J. Cancer, 10, p. 6395, DOI: 10.7150/jca.31254 13 10.7150/jca.31254 false true Reference 37066594 /api/reference/37066594 14. LaValle 2012: Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer., Mol. Cancer Ther., 11, p. 1389, DOI: 10.1158/1535-7163.MCT-11-0887 14 10.1158/1535-7163.MCT-11-0887 false true Reference 37066595 /api/reference/37066595 15. Zou 2012: PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-kappaB- and HDAC1-mediated expression and activation of uPA., J. Cell Sci., 125, p. 4800 15 false true Reference 37066596 /api/reference/37066596 16. Csermely 1998: The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review., Pharmacol. Ther., 79, p. 129, DOI: 10.1016/S0163-7258(98)00013-8 16 10.1016/S0163-7258(98)00013-8 false true Reference 37066597 /api/reference/37066597 17. Biebl 2019: Structure, Function, and Regulation of the Hsp90 Machinery., Cold Spring Harb. Perspect. Biol., 11, p. a034017, DOI: 10.1101/cshperspect.a034017 17 10.1101/cshperspect.a034017 false true Reference 37066598 /api/reference/37066598 18. Taipale 2010: HSP90 at the hub of protein homeostasis: Emerging mechanistic insights., Nat. Rev. Mol. Cell Bio., 11, p. 515, DOI: 10.1038/nrm2918 18 10.1038/nrm2918 false true Reference 37066599 /api/reference/37066599 19. Taipale 2012: Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition., Cell, 150, p. 987, DOI: 10.1016/j.cell.2012.06.047 19 10.1016/j.cell.2012.06.047 false true Reference 37066600 /api/reference/37066600 20. Azoitei 2014: HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization., Cancer Res., 74, p. 7125, DOI: 10.1158/0008-5472.CAN-14-1017 20 10.1158/0008-5472.CAN-14-1017 false true Reference 37066601 /api/reference/37066601 21. Solit 2002: 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts., Clin. Cancer Res., 8, p. 986 21 false true Reference 37066602 /api/reference/37066602 22. Whitesell 2005: HSP90 and the chaperoning of cancer., Nat. Rev. Cancer, 5, p. 761, DOI: 10.1038/nrc1716 22 10.1038/nrc1716 false true Reference 37066603 /api/reference/37066603 23. Jaeger 2019: HSP90: Enabler of Cancer Adaptation., Annu. Rev. Annu. Rev. Cancer Biol., 97, p. 275, DOI: 10.1146/annurev-cancerbio-030518-055533 23 10.1146/annurev-cancerbio-030518-055533 false true Reference 37066604 /api/reference/37066604 24. Prodromou 1997: Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone., Cell, 90, p. 65, DOI: 10.1016/S0092-8674(00)80314-1 24 10.1016/S0092-8674(00)80314-1 false true Reference 37066605 /api/reference/37066605 25. Ying 2012: Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy., Mol. Cancer Ther., 11, p. 475, DOI: 10.1158/1535-7163.MCT-11-0755 25 10.1158/1535-7163.MCT-11-0755 false true Reference 37066606 /api/reference/37066606 26. Proia 2014: Ganetespib and HSP90: Translating preclinical hypotheses into clinical promise., Cancer Res., 74, p. 1294, DOI: 10.1158/0008-5472.CAN-13-3263 26 10.1158/0008-5472.CAN-13-3263 false true Reference 37066607 /api/reference/37066607 27. Fu 2022: Advances in the role of heat shock protein 90 in prostate cancer., Andrologia, 54, p. e14376, DOI: 10.1111/and.14376 27 10.1111/and.14376 false true Reference 37066608 /api/reference/37066608 28. Alqawi 2006: Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells., Prostate Cancer Prostatic Dis., 9, p. 126, DOI: 10.1038/sj.pcan.4500852 28 10.1038/sj.pcan.4500852 false true Reference 37066609 /api/reference/37066609 29. Peng 2015: The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells., Am. J. Cancer Res., 5, p. 3198 29 false true Reference 37066610 /api/reference/37066610 30. Armstrong 2018: Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion., Sci. Rep., 8, p. 2090, DOI: 10.1038/s41598-018-19871-4 30 10.1038/s41598-018-19871-4 false true Reference 37066611 /api/reference/37066611 31. Nguyen 2013: Hsp90 chaperones PPARgamma and regulates differentiation and survival of 3T3-L1 adipocytes., Cell Death Differ., 20, p. 1654, DOI: 10.1038/cdd.2013.129 31 10.1038/cdd.2013.129 false true Reference 37066612 /api/reference/37066612 32. Sato 2000: Modulation of Akt kinase activity by binding to Hsp90., Proc. Natl. Acad. Sci. USA, 97, p. 10832, DOI: 10.1073/pnas.170276797 32 10.1073/pnas.170276797 false true Reference 37066613 /api/reference/37066613 33. Alam 2018: Proximity Ligation Assay (PLA)., Curr. Protoc. Immunol., 123, p. e58, DOI: 10.1002/cpim.58 33 10.1002/cpim.58 false true Reference 37066614 /api/reference/37066614 34. Basso 2002: Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function., J. Biol. Chem., 277, p. 39858, DOI: 10.1074/jbc.M206322200 34 10.1074/jbc.M206322200 false true Reference 37066615 /api/reference/37066615 35. Giubellino, A., Sourbier, C., Lee, M.J., Scroggins, B., Bullova, P., Landau, M., Ying, W., Neckers, L., Trepel, J.B., and Pacak, K. (2013). Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma. PLoS ONE, 8., DOI: 10.1371/journal.pone.0056083 35 10.1371/journal.pone.0056083 false true Reference 37066616 /api/reference/37066616 36. Eiseler 2009: Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot., Nat. Cell Biol., 11, p. 545, DOI: 10.1038/ncb1861 36 10.1038/ncb1861 false true Reference 37066617 /api/reference/37066617 37. Siebert 2019: Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma., Front. Endocrinol., 10, p. 487, DOI: 10.3389/fendo.2019.00487 37 10.3389/fendo.2019.00487 false true Reference 37066618 /api/reference/37066618 38. Kumar 2020: The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis., Cancer Rep., 5, p. e1261 38 false true Reference 37066619 /api/reference/37066619 39. Rozengurt 2005: Protein kinase D signaling., J. Biol. Chem., 280, p. 13205, DOI: 10.1074/jbc.R500002200 39 10.1074/jbc.R500002200 false true Reference 37066620 /api/reference/37066620 40. Baker, J., Falconer, A.M.D., Wilkinson, D.J., Europe-Finner, G.N., Litherland, G.J., and Rowan, A.D. (2018). Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes. PLoS ONE, 13., DOI: 10.1371/journal.pone.0195864 40 10.1371/journal.pone.0195864 false true Reference 37066621 /api/reference/37066621 41. Rey 2003: Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists., J. Biol. Chem., 278, p. 23773, DOI: 10.1074/jbc.M300226200 41 10.1074/jbc.M300226200 false true Reference 37066622 /api/reference/37066622 42. Rodina 2016: The epichaperome is an integrated chaperome network that facilitates tumour survival., Nature, 538, p. 397, DOI: 10.1038/nature19807 42 10.1038/nature19807 false true Reference 37066623 /api/reference/37066623 43. Moulick 2011: Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90., Nat. Chem. Biol., 7, p. 818, DOI: 10.1038/nchembio.670 43 10.1038/nchembio.670 false true Reference 37066624 /api/reference/37066624 44. Huck 2012: GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity., J. Biol. Chem., 287, p. 34604, DOI: 10.1074/jbc.M112.374652 44 10.1074/jbc.M112.374652 false true Reference 37066625 /api/reference/37066625 45. Chakraborty 2021: HSP90 as a regulator of extracellular matrix dynamics., Biochem. Soc. Trans., 49, p. 2611, DOI: 10.1042/BST20210374 45 10.1042/BST20210374 false true Reference 37066626 /api/reference/37066626 46. Hashmi 2019: Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis., Cell Rep., 28, p. 1894, DOI: 10.1016/j.celrep.2019.07.045 46 10.1016/j.celrep.2019.07.045 false true Reference 37066627 /api/reference/37066627 47. Xu 2019: Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment., J. Exp. Clin. Cancer Res., 38, p. 114, DOI: 10.1186/s13046-019-1118-y 47 10.1186/s13046-019-1118-y false true Reference 37066628 /api/reference/37066628 48. Huck 2014: Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation., J. Biol. Chem., 289, p. 3138, DOI: 10.1074/jbc.M113.502633 48 10.1074/jbc.M113.502633 false true Reference 37066629 /api/reference/37066629 49. Liu 2020: Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c-MYC axis in breast cancer., J. Cell Mol. Med., 24, p. 2135, DOI: 10.1111/jcmm.14772 49 10.1111/jcmm.14772 false true Reference 37066630 /api/reference/37066630 50. Hao 2013: Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells., Anticancer Res., 33, p. 393 50 false true Reference 37066631 /api/reference/37066631 51. Cui 2020: Protein kinase D3 regulates the expression of the immunosuppressive protein, PDL1, through STAT1/STAT3 signaling., Int. J. Oncol., 56, p. 909 51 false true Reference 37066632 /api/reference/37066632 52. Mayer 2019: The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling., Sci. Signal., 12, p. eaav9150, DOI: 10.1126/scisignal.aav9150 52 10.1126/scisignal.aav9150 false true Reference 37066633 /api/reference/37066633 53. Li 2011: Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors., J. Biol. Chem., 286, p. 40782, DOI: 10.1074/jbc.M111.263046 53 10.1074/jbc.M111.263046 false true Reference 37066634 /api/reference/37066634 54. Zhang 2020: Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice., Hepatology, 72, p. 1717, DOI: 10.1002/hep.31176 54 10.1002/hep.31176 false true Reference 37066635 /api/reference/37066635 55. Ellwanger, K., Pfizenmaier, K., Lutz, S., and Hausser, A. (2008). Expression patterns of protein kinase D 3 during mouse development. BMC Dev. Biol., 8., DOI: 10.1186/1471-213X-8-47 55 10.1186/1471-213X-8-47 false true Reference 37066636 /api/reference/37066636 56. Nakai 2001: Cell cycle transition under stress conditions controlled by vertebrate heat shock factors., EMBO J., 20, p. 2885, DOI: 10.1093/emboj/20.11.2885 56 10.1093/emboj/20.11.2885 false true Reference 37066637 /api/reference/37066637 57. Nardai 2002: Chaperone function and chaperone overload in the aged. A preliminary analysis., Exp. Gerontol., 37, p. 1257, DOI: 10.1016/S0531-5565(02)00134-1 57 10.1016/S0531-5565(02)00134-1 false true Reference 37066638 /api/reference/37066638 58. Hipp 2019: The proteostasis network and its decline in ageing., Nat. Rev. Mol. Cell Biol., 20, p. 421, DOI: 10.1038/s41580-019-0101-y 58 10.1038/s41580-019-0101-y false true Reference 37066639 /api/reference/37066639 59. Kurop 2021: The heat shock response and small molecule regulators., Eur. J. Med. Chem., 226, p. 113846, DOI: 10.1016/j.ejmech.2021.113846 59 10.1016/j.ejmech.2021.113846 false true /api/publication/33541689 Varga Attila et al. Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration. (2023) CELLS 2073-4409 12 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10040840"><a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga Attila ✉ (<span class="authorship-author-name">Varga Attila</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030308"><a href="/gui2/?type=authors&mode=browse&sel=10030308" target="_blank">Nguyen Minh Tu (<span class="authorship-author-name">Nguyen Minh Tu</span> <span class="authorAux-mtmt"> biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044963"><a href="/gui2/?type=authors&mode=browse&sel=10044963" target="_blank">Pénzes Kinga (<span class="authorship-author-name">Pénzes Kinga</span> <span class="authorAux-mtmt"> sejtbiológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076784"><a href="/gui2/?type=authors&mode=browse&sel=10076784" target="_blank">Bátai Bence (<span class="authorship-author-name">Bátai Bence</span> <span class="authorAux-mtmt"> Onkohematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Patológiai és Kísérleti Rákkutató Intézet">PKRI</span>/HCEMM-SE Molekuláris Onkohematológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028916"><a href="/gui2/?type=authors&mode=browse&sel=10028916" target="_blank">Gyulavári Pál (<span class="authorship-author-name">Gyulavári Pál</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059086"><a href="/gui2/?type=authors&mode=browse&sel=10059086" target="_blank">Gurbi Bianka (<span class="authorship-author-name">Gurbi Bianka</span> <span class="authorAux-mtmt"> célzott daganatterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047778"><a href="/gui2/?type=authors&mode=browse&sel=10047778" target="_blank">Murányi József (<span class="authorship-author-name">Murányi József</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035707"><a href="/gui2/?type=authors&mode=browse&sel=1035707" target="_blank">Csermely Péter (<span class="authorship-author-name">Csermely Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009602"><a href="/gui2/?type=authors&mode=browse&sel=10009602" target="_blank">Vántus Tibor (<span class="authorship-author-name">Vántus Tibor</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biokémiai és Molekuláris Biológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012506"><a href="/gui2/?type=authors&mode=browse&sel=10012506" target="_blank">Sőti Csaba ✉ (<span class="authorship-author-name">Sőti Csaba</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33541689" target="_blank">Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">2</span> <span class="page"> Paper 212. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells12020212" target="_blank" href="https://doi.org/10.3390/cells12020212"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000916995200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000916995200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85146784516" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85146784516"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36672148" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36672148&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 8 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33541689&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33541689</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K 124813) Támogató: NKFIH, (OTKA K116525) Támogató: NKFI, (K131458), (TKP2021-EGA-24) </div> <div class="lastModified">Utolsó módosítás: 2024.05.30. 14:05 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Molecular Biology, Semmelweis University, Budapest, 1094, Hungary MTA-SE Pathobiochemistry Research Group, Semmelweis University, Budapest, 1094, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1089, Hungary HCEMM-SU Molecular Oncohematology Research Group, Department of Pathology a...</pre> </div></div>