During tissue damage caused by infection or sterile inflammation, not only damage-associated
molecular patterns (DAMPs), but also resolution-associated molecular patterns (RAMPs)
can be activated. These dying cell-associated factors stimulate immune cells localized
in the tissue environment and induce the production of inflammatory mediators or specialized
proresolving mediators (SPMs). Within the current prospect of science, apoptotic cell
death is considered the main initiator of resolution. However, more RAMPs are likely
to be released during necrotic cell death than during apoptosis, similar to what has
been observed for DAMPs. The inflammatory potential of many regulated forms of necrotic
cell death modalities, such as pyroptosis, necroptosis, ferroptosis, netosis, and
parthanatos, have been widely studied in necroinflammation, but their possible role
in resolution is less considered. In this review, we aim to summarize the relationship
between necrotic cell death and resolution, as well as present the current available
data regarding the involvement of certain forms of regulated necrotic cell death in
necroresolution.
