Anti-inflammatory Activity of Melampyrum barbatum and Isolation of Iridoid and Flavonoid Compounds

Háznagy-Radnai, Erzsébet [Háznagyné Radnai, Erzsébet (Farmakognózia), author] Department of Pharmacognosy (USZ / FP); Fási, Laura [Fási, Laura (farmakognózia), author] Department of Pharmacognosy (USZ / FP); Wéber, Edit [Wéber, Edit (gyógyszerkémia), author]; Pinke, Gyula [Pinke, Gyula (Botanika,herbológia), author] Mezőgazdaság- és Élelmiszertudományi Kar; Király, Gergely [Király, Botond Gergely (ökológia, botanik...), author]; Sztojkov-Ivanov, Anita [Sztojkov-Ivanov, Anita (nagyhatékonyságú ...), author] Department of Pharmacodynamics and Biopharmacy (USZ / FP); Gáspár, Róbert [Gáspár, Róbert (Reprodukciós farm...), author] Department of Pharmacodynamics and Biopharmacy (USZ / FP); Hohmann, Judit [Hohmann, Judit (Farmakognózia), author] Interdisciplinary Centre for Natural Products (USZ / KE)

English Scientific Article (Journal Article)
Published: NATURAL PRODUCT COMMUNICATIONS 1934-578X 1555-9475 13 (3) pp. 235-236 2018
  • SJR Scopus - Complementary and Alternative Medicine: Q2
    Melampyrum barbatum Waldst. & Kit. ex Willd. (Scrophulariaceae) has been used in traditional medicine for the treatment of rheumatic complaints and different skin diseases. In the course of our study the anti-inflammatory activity of the aerial parts of M barbatum was evaluated. A MeOH extract was prepared and consecutively partitioned with CHCl3, EtOAc and n-BuOH. The fractions were assayed in in vivo carrageenan-induced rat paw oedema model. The intraperitoneally administered n-BuOH phase exerted marked inhibitory effect (33.6 %, p < 0.01). Multistep chromatographic separation afforded mussaenoside and aucubine from n-BuOH fraction. Moreover, 8-epiloganin, loganic acid and mussaenoside were obtained from EtOAc fraction and apigenin, luteolin, benzoic acid and galactitol from CHCl3 fraction. These data validate the ethnomedicinal use of M barbatum for the treatment of inflammatory diseases and reveal that iridoids and flavonoids could be responsible for the anti-inflammatory effect of this species.
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    2020-07-02 17:51