https://m2.mtmt.hu/ hun 2026-10-25 12:42 JournalArticle 3343168 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 3343168 2026-10-18T16:14:08.712+0000 2026-02-10T12:39:13.603+0000 2018-03-05T10:35:34.000+0000 true 10002629 Hegyi Péter /api/author/10002629 Author true 10002629 2026-02-10T12:39:13.079+0000 2024-11-28T05:49:46.630+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Migh, E Microtubule organization in presynaptic boutons relies on the formin DAAM true true /api/journal/1302 REVIEWED true false 1302 false 1302 true 0950-1991 1477-9129 Journal FOREIGN 145 6 dev158519 dev158519 13 2018 Regulation of the cytoskeleton is fundamental to the development and functioning of synaptic terminals, such as neuromuscular junctions. Nevertheless, despite identification of numerous proteins that regulate synaptic actin and microtubule dynamics, the mechanisms of cytoskeletal control during terminal arbor formation has remained largely elusive. Here, we show that DAAM, a member of the formin family of cytoskeleton organizing factors, is an important presynaptic regulator of neuromuscular junction development in Drosophila We demonstrate that the actin filament assembly activity of DAAM plays a negligible role in terminal formation; rather, DAAM is necessary for synaptic microtubule organization. Genetic interaction studies consistently link DAAM with the Wg/Ank2/Futsch module of microtubule regulation and bouton formation. Finally, we provide evidence that DAAM is tightly associated with the synaptic active zone scaffold, and electrophysiological data point to a role in the modulation of synaptic vesicle release. Based on these results, we propose that DAAM is an important cytoskeletal effector element of the Wg/Ank2 pathway involved in the determination of basic synaptic structures, and, additionally, DAAM may couple the active zone scaffold to the presynaptic cytoskeleton. 2018 909042 true true true false true false GOLD 2026-10-18 true https://doi.org/10.1242/dev.158519 25 0 23 15 3 24 23 22 21 22 22 14 14 16 9 0 25 16 23 15 0 6 6 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 7 5 7 5 2020 0 3 2 3 2 2021 0 3 2 3 2 2022 0 1 0 1 0 2023 0 1 0 1 0 2024 0 3 2 3 2 2025 0 3 2 3 2 2026 0 4 3 4 3 D1 false 10026337 false false false 2018-05-17T10:40:12.000+0000 2018-03-05T10:50:32.000+0000 Biokémiai Intézet (HRN SZBK); Genetikai Intézet (HRN SZBK); MTA-SZBK-NAP B Axon növekedés és regeneráció ku... (HRN SZBK / GI); MTA-SZTE Lendület Gasztroenterológiai Multidisz... (SZTE / SZAOK / BK / I.BelK); Transzlációs Medicina Intézet (PTE / ÁOK) 9 47 5 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 9879882 /api/authorship/9879882 1 0.09090909 true false Author 10040911 /api/author/10040911 Migh Ede true 10040911 true Migh E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815781 true PersonAuthorship 9879883 /api/authorship/9879883 2 0.09090909 false false Gotz T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815780 true PersonAuthorship 9879884 /api/authorship/9879884 3 0.09090909 false false Author 10026337 /api/author/10026337 Földi István true 10026337 true Foldi I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815779 true PersonAuthorship 9879885 /api/authorship/9879885 4 0.09090909 false false Author 10030426 /api/author/10030426 Szikora Szilárd true 10030426 true Szikora S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815778 true PersonAuthorship 9879886 /api/authorship/9879886 5 0.09090909 false false Author 10024995 /api/author/10024995 Gombos Rita I true 10024995 true Gombos R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815777 true PersonAuthorship 9879887 /api/authorship/9879887 6 0.09090909 false false Author 10013561 /api/author/10013561 Darula Zsuzsanna true 10013561 true Darula Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815776 true PersonAuthorship 9879888 /api/authorship/9879888 7 0.09090909 false false Author 10001349 /api/author/10001349 Medzihradszky F. Katalin true 10001349 true Medzihradszky KF true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815775 true PersonAuthorship 9879889 /api/authorship/9879889 8 0.09090909 false false Author 10030084 /api/author/10030084 Maléth József true 10030084 true Maleth J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815774 true PersonAuthorship 9879890 /api/authorship/9879890 9 0.09090909 false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815773 true PersonAuthorship 9879891 /api/authorship/9879891 10 0.09090909 false false Sigrist S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815772 true PersonAuthorship 9879892 /api/authorship/9879892 11 0.091 false true true Author 10010519 /api/author/10010519 Mihály József true 10010519 true Mihaly J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27815771 true PublicationIdentifier 1279855 /api/publicationidentifier/1279855 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1242/dev.158519 https://doi.org/10.1242/dev.158519 false 1734420 true PublicationIdentifier 15164556 /api/publicationidentifier/15164556 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 90882 https://real.mtak.hu/90882 false true PublicationIdentifier 1279853 /api/publicationidentifier/1279853 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000427697300008 https://www.webofscience.com/wos/woscc/full-record/000427697300008 false 1750410 true PublicationIdentifier 1279854 /api/publicationidentifier/1279854 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 85044269202 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85044269202 false 1752723 true PublicationIdentifier 1279856 /api/publicationidentifier/1279856 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 29487108 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29487108&dopt=Abstract false 1734421 true PublicationIdentifier 15630283 /api/publicationidentifier/15630283 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 15522 http://publicatio.bibl.u-szeged.hu/15522 false true Classification 10545 /api/classification/10545 true true SjrRating 10986039 /api/sjrrating/10986039 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1309 /api/classificationexternal/1309 true 1309 true D1 DIRECT true true /api/publication/3343168 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10040911"><a href="/gui2/?type=authors&mode=browse&sel=10040911" target="_blank">Migh E (<span class="authorship-author-name">Migh Ede</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gotz T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026337"><a href="/gui2/?type=authors&mode=browse&sel=10026337" target="_blank">Foldi I (<span class="authorship-author-name">Földi István</span> <span class="authorAux-mtmt"> Biologia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030426"><a href="/gui2/?type=authors&mode=browse&sel=10030426" target="_blank">Szikora S (<span class="authorship-author-name">Szikora Szilárd</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024995"><a href="/gui2/?type=authors&mode=browse&sel=10024995" target="_blank">Gombos R (<span class="authorship-author-name">Gombos Rita I</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013561"><a href="/gui2/?type=authors&mode=browse&sel=10013561" target="_blank">Darula Z (<span class="authorship-author-name">Darula Zsuzsanna</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001349"><a href="/gui2/?type=authors&mode=browse&sel=10001349" target="_blank">Medzihradszky KF (<span class="authorship-author-name">Medzihradszky F. Katalin</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030084"><a href="/gui2/?type=authors&mode=browse&sel=10030084" target="_blank">Maleth J (<span class="authorship-author-name">Maléth József</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="I. sz. Belgyógyászati Klinika">I.BelK</span>/MTA-SZTE Lendület Gasztroenterológiai Multidiszciplináris Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi P (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="I. sz. Belgyógyászati Klinika">I.BelK</span>/MTA-SZTE Lendület Gasztroenterológiai Multidiszciplináris Kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sigrist S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihaly J ✉ (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/<span title="Genetikai Intézet">GI</span>/MTA-SZBK-NAP B Axon növekedés és regeneráció kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3343168" target="_blank">Microtubule organization in presynaptic boutons relies on the formin DAAM</a></div> <div> <span class="journal-title">DEVELOPMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0950-1991">0950-1991</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-9129">1477-9129</a>)</span>: <span class="journal-volume">145</span> <span class="journal-issue">6</span> <span class="page"> Paper dev158519. 13 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1242/dev.158519" target="_blank" href="https://doi.org/10.1242/dev.158519"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="90882" target="_blank" href="https://real.mtak.hu/90882"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000427697300008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000427697300008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85044269202" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85044269202"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="29487108" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=29487108&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="15522" target="_blank" href="http://publicatio.bibl.u-szeged.hu/15522"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 25</span> | Független: 16 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;22 | DOI jelölt:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3343168&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3343168</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3343168</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.10. 13:39 Heronyányi Zsolt (PTE ÁOK admin 5) </div> </div></div>