https://m2.mtmt.hu/ hun 2026-04-29 23:10 JournalArticle 3341590 VALIDATED true 0 2018-07-02T22:24:23.000+0000 false 3341590 2026-04-20T13:40:15.539+0000 2026-02-02T13:29:02.417+0000 2018-03-01T09:01:45.000+0000 true 10002738 Keltai Mátyás /api/author/10002738 Author true 10002738 2026-04-01T12:44:09.938+0000 2026-04-01T12:44:09.938+0000 2024-11-29T08:57:09.028+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10013962 /api/admin/10013962 Vasvari Lilian true 10013962 true 2025-01-23T17:25:20.589+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Eikelboom, JW Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 377 14 1319 1330 1319 12 2017 BACKGROUND We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P< 0.001; z = -4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P< 0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P = 0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban- alone group. CONCLUSIONS Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events. 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220 258 220 2023 0 228 210 228 210 2024 0 232 200 232 200 2025 0 195 171 195 171 2026 0 4 4 4 4 D1 false false false false 2019-01-31T22:59:00.000+0000 2018-03-01T09:02:55.000+0000 Belgyógyászat, Kardiológia (FVSZGYEOK); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Általános Orvostudományi Kar (PTE) 13 47 3 49 33 true 10013962 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 9863545 /api/authorship/9863545 1 0.02 true false true Eikelboom JW true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724758 true OrgAuthorship 93843632 /api/authorship/93843632 2 0.0 false false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false true PersonAuthorship 9863546 /api/authorship/9863546 2 0.02 false false Connolly SJ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724757 true PersonAuthorship 9863547 /api/authorship/9863547 3 0.02 false false Bosch J true false false 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Lopez-Jaramillo P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724737 true PersonAuthorship 9863566 /api/authorship/9863566 22 0.02 false false O'Donnell M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724736 true PersonAuthorship 9863567 /api/authorship/9863567 23 0.02 false false Kakkar AK true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724735 true PersonAuthorship 9863568 /api/authorship/9863568 24 0.02 false false Fox KAA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724734 true PersonAuthorship 9863569 /api/authorship/9863569 25 0.02 false false Parkhomenko AN true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724733 true PersonAuthorship 9863570 /api/authorship/9863570 26 0.02 false false Ertl G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27724732 true PersonAuthorship 9863571 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(49) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10023829"><a href="/gui2/?type=authors&mode=browse&sel=10023829" target="_blank">Keltai Katalin (<span class="authorship-author-name">Keltai Katalin</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016411"><a href="/gui2/?type=authors&mode=browse&sel=10016411" target="_blank">L. Bajnok (<span class="authorship-author-name">Bajnok László Zoltán</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Általános Orvostudományi Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032482"><a href="/gui2/?type=authors&mode=browse&sel=10032482" target="_blank">Z. Laszlo (<span class="authorship-author-name">László Zoltán</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028344"><a href="/gui2/?type=authors&mode=browse&sel=10028344" target="_blank">D. Aradi (<span class="authorship-author-name">Aradi Dániel</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072650"><a href="/gui2/?type=authors&mode=browse&sel=10072650" target="_blank">E. Noori (<span class="authorship-author-name">Noori Ebrahim</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Fejér Megyei Szent György Egyetemi Oktató Kórház">FMSZGYEOK</span>/Belgyógyászat, Kardiológia</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023788"><a href="/gui2/?type=authors&mode=browse&sel=10023788" target="_blank">Zsary A (<span class="authorship-author-name">Zsáry András</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat, intenzív</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008869"><a href="/gui2/?type=authors&mode=browse&sel=10008869" target="_blank">L. Koranyi (<span class="authorship-author-name">Korányi László</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004245"><a href="/gui2/?type=authors&mode=browse&sel=10004245" target="_blank">Boda Z (<span class="authorship-author-name">Boda Zoltán</span> <span class="authorAux-mtmt"> Belgyógyászat, haemostasis</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052973"><a href="/gui2/?type=authors&mode=browse&sel=10052973" target="_blank">K. Razso (<span class="authorship-author-name">Rázsó Katalin</span> <span class="authorAux-mtmt"> belgyógyászat, kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014929"><a href="/gui2/?type=authors&mode=browse&sel=10014929" target="_blank">Z. Jarai (<span class="authorship-author-name">Járai Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024040"><a href="/gui2/?type=authors&mode=browse&sel=10024040" target="_blank">L. Sallai (<span class="authorship-author-name">Sallai László</span> <span class="authorAux-mtmt"> belgyógyászat, kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077102"><a href="/gui2/?type=authors&mode=browse&sel=10077102" target="_blank">Benedek Imre (<span class="authorship-author-name">Benedek Imre-Sándor</span> <span class="authorAux-mtmt"> Invazív kardiológia, Elektrofiziológia, Kardiol...</span>) </a> </span> et al. (33) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">COMPASS Investigators</span> </div> <div><a target="_blank" href="/api/publication/3341590?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3341590" target="_blank">Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">377</span> <span class="journal-issue">14</span> <span class="page"> pp 1319-1330 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa1709118" target="_blank" href="https://doi.org/10.1056/NEJMoa1709118"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000412375000012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000412375000012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85029804845" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85029804845"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28844192" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28844192&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="http://www.nejm.org/doi/10.1056/NEJMoa1709118" target="_blank" href="http://www.nejm.org/doi/10.1056/NEJMoa1709118"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2,150</span> | Független: 1,904 | Függő: 246 | Nem jelölt: 0 | WoS jelölt: 1,922 | Scopus jelölt:&nbsp;2,094 | WoS/Scopus jelölt:&nbsp;2,150 | DOI jelölt:&nbsp;2,050 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3341590&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3341590</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3341590</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.02. 14:29 Eötvös Péter Mátyás (Szt János Kórház admin4) </div> <div class="lockedBy">Központi kezelésű 2025.01.23. 18:25 Vasvari Lilian (MTMT Központ, admin) </div> </div></div>