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3555, "link" : "/api/journal/3555", "label" : "PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 0147-8389 1540-8159", "pIssn" : "0147-8389", "eIssn" : "1540-8159", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 3555, "snippet" : true }, "volume" : "40", "issue" : "12", "firstPage" : "1432", "lastPage" : "1439", "firstPageOrInternalIdForSort" : "1432", "pageLength" : 8, "publishedYear" : 2017, "abstractText" : "BackgroundSilent cerebral lesions (SCLs) are a potential complication of left atrial radiofrequency ablation (RFA) procedures for paroxysmal atrial fibrillation (PAF). We aimed to compare the incidence of SCLs in patients treated with irrigated RFA multielectrode catheters (nMARQ((R)) Catheter group) and irrigated focal RFA catheters (NAVISTAR((R)) THERMOCOOL (R) Catheter; TC group) after PAF ablation from subpopulation neurological assessment (SNA) cohorts of the REVOLUTION and reMARQable studies. MethodsData from SNA cohorts in the prospective, nonrandomized REVOLUTION study (March 2011-September 2013) and the prospective, randomized, controlled reMARQable study (October 2013-November 2015) were included. The incidence of SCLs was assessed pre- and postablation using magnetic resonance imaging. Neurological deficits were assessed using the National Institutes of Health Stroke Scale, modified Rankin Scale, and Montreal Cognitive Assessment. ResultsA total of 37 patients from REVOLUTION and 76 patients from reMARQable were included in the SNA cohort of each study. In the REVOLUTION SNA cohort, the incidence of SCLs was 21.1% (4/19) in the nMARQ((R)) Catheter group and 5.9% (1/17) in the TC group. Findings from REVOLUTION helped inform the reMARQable study protocol's stringent anticoagulation regimen. SCL incidence was subsequently reduced in both groups (nMARQ((R)) Catheter, 7.9%; TC, 3.3%). No permanent neurological deficits were observed. 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