https://m2.mtmt.hu/ hun 2026-09-23 01:41 JournalArticle 3341442 ADMIN_APPROVED true Klinikum der Universität München, Department of Medicine, Munich, Bayern, Germany Universitätsklinikum Münster, Munster, Niedersachsen, Germany Bayer AG, Leverkusen, Germany Humanitas Research Hospital, Rozzano, MI, Italy Alma Mater Studiorum Università di Bologna, Bologna, BO, Italy Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada Helsingin Yliopisto, Helsinki, Uusimaa, Finland Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom Samsung Medical Center, Sungkyunkwan university, Seoul, South Korea Tel Aviv University, Tel Aviv-Yafo, Tel Aviv District, Israel National and Kapodistrian University of Athens, Athens, Attica, Greece Semmelweis Egyetem, Budapest, Hungary Ankara Üniversitesi, School of Medicine, Ankara, Turkey Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation Centre Hospitalier Universitaire de Bordeaux, Talence, Nouvelle-Aquitaine, France CHU Lille, Lille, Hauts-de-France, France Norton Cancer Institute, Louisville, KY, United States Clinical Research Groups of Colorado, Comprehensive Cancer Care, Englewood, CO, United States Bayer Corporation, USA, Whippany, NJ, United States Export Date: 27 November 2025; Cited By: 345; Correspondence Address: M. Dreyling; Department of Medicine III, University Hospital, Ludwig Maximilians University of Munich, Munich, Marchioninistraße 15, 81377, Germany; email: martin.dreyling@med.uni-muenchen.de; CODEN: JCOND 0 2018-07-02T22:24:22.000+0000 false 3341442 2026-07-17T00:13:50.942+0000 2025-11-27T12:32:22.312+0000 2018-02-28T17:41:14.000+0000 true 10005206 Demeter Judit /api/author/10005206 Author true 10005206 2025-11-27T12:32:22.169+0000 2024-05-25T17:05:26.030+0000 true 10071338 Molnár-Taga Márta /api/admin/10071338 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dreyling, M Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma true true /api/journal/2374 REVIEWED true false 2374 false 2374 true 0732-183X 1527-7755 Journal FOREIGN 35 35 3898 3905 3898 12 2017 PurposePhosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K- and - isoforms, has demonstrated efficacy and a manageable safety profile in patients with indolent lymphoma.Patients and MethodsIn this phase II study, 142 patients with relapsed or refractory indolent lymphoma after two or more lines of therapy were enrolled to receive copanlisib 60 mg intravenously on days 1, 8, and 15 of a 28-day cycle. The primary end point was objective response rate; secondary end points included duration of response, progression-free survival, and overall survival. In addition, safety and gene expression were evaluated.ResultsMedian age was 63 years (range, 25 to 82 years), and patients had received a median of three (range, two to nine) prior regimens. The objective response rate was 59% (84 of 142 patients); 12% of patients achieved a complete response. Median time to response was 53 days. Median duration of response was 22.6 months, median progression-free survival was 11.2 months, and median overall survival had not yet been reached. The most frequent treatment-emergent adverse events were transient hyperglycemia (all grades, 50%; grade 3 or 4, 41%) and transient hypertension (all grades, 30%; grade 3, 24%). Other grade 3 events included decreased neutrophil count (24%) and lung infection (15%). High response rates to copanlisib were associated with high expression of PI3K/B-cell receptor signaling pathway genes.ConclusionPI3K- and - inhibition by copanlisib demonstrated significant efficacy and a manageable safety profile in heavily pretreated patients with relapsed or refractory indolent lymphoma. 2018 882899 true true true false true false NONE 2026-07-17 false 369 0 369 320 1 365 354 348 340 369 369 320 320 320 49 0 369 320 369 320 0 2 2 Folyóiratcikk Journal Article 24 354 Könyvrészlet Chapter in Book 25 14 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 2 2 2 2 2018 0 37 33 37 33 2019 0 49 44 49 44 2020 0 44 37 44 37 2021 0 69 57 69 57 2022 0 52 48 52 48 2023 0 50 41 50 41 2024 0 31 28 31 28 2025 0 21 17 21 17 2026 0 14 13 14 13 D1 false false false false 2019-01-31T22:59:00.000+0000 2018-02-28T17:42:30.000+0000 I. 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0.037037037 false false Ozcan M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716549 true PersonAuthorship 9855828 /api/authorship/9855828 12 0.037037037 false false Kosinova M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716548 true PersonAuthorship 9855829 /api/authorship/9855829 13 0.037037037 false false Bouabdallah K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716547 true PersonAuthorship 9855830 /api/authorship/9855830 14 0.037037037 false false Morschhauser F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716546 true PersonAuthorship 9855831 /api/authorship/9855831 15 0.037037037 false false Stevens DA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716545 true PersonAuthorship 9855832 /api/authorship/9855832 16 0.037037037 false false Trevarthen D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716544 true PersonAuthorship 9855833 /api/authorship/9855833 17 0.037037037 false false Giurescu M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716543 true PersonAuthorship 9855834 /api/authorship/9855834 18 0.037037037 false false Cupit L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716542 true PersonAuthorship 9855835 /api/authorship/9855835 19 0.037037037 false false Liu L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716541 true PersonAuthorship 9855836 /api/authorship/9855836 20 0.037037037 false false Kochert K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716540 true PersonAuthorship 9855837 /api/authorship/9855837 21 0.037037037 false false Seidel H true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 27716539 true PersonAuthorship 9855838 /api/authorship/9855838 22 0.037037037 false false Pena C true false false 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1258187 /api/keyword/1258187 true 1258187 true Keyword 1470121 /api/keyword/1470121 true 1470121 true Keyword 1470122 /api/keyword/1470122 true 1470122 true Keyword 1470123 /api/keyword/1470123 true 1470123 true Keyword 1470124 /api/keyword/1470124 true 1470124 true Keyword 1470125 /api/keyword/1470125 true 1470125 true SjrRating 10971857 /api/sjrrating/10971857 11 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/3341442 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dreyling M ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Santoro A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mollica L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leppa S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Follows GA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lenz G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim WS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagler A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Panayiotidis P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005206"><a href="/gui2/?type=authors&mode=browse&sel=10005206" target="_blank">Demeter J (<span class="authorship-author-name">Demeter Judit</span> <span class="authorAux-mtmt"> Hematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. 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Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ozcan M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kosinova M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bouabdallah K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Morschhauser F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stevens DA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Trevarthen D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Giurescu M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cupit L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kochert K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seidel H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pena C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yin SX </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hiemeyer F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garcia-Vargas J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Childs BH </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zinzani PL </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3341442" target="_blank">Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0732-183X">0732-183X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1527-7755">1527-7755</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">35</span> <span class="page"> pp 3898-3905 </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1200/JCO.2017.75.4648" target="_blank" href="https://doi.org/10.1200/JCO.2017.75.4648"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000417565500003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000417565500003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85037176051" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85037176051"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28976790" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28976790&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 369</span> | Független: 320 | Függő: 49 | Nem jelölt: 0 | WoS jelölt: 348 | Scopus jelölt:&nbsp;340 | WoS/Scopus jelölt:&nbsp;369 | DOI jelölt:&nbsp;354 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3341442&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3341442</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 3341442</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2025.11.27. 13:32 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Klinikum der Universität München, Department of Medicine, Munich, Bayern, Germany Universitätsklinikum Münster, Munster, Niedersachsen, Germany Bayer AG, Leverkusen, Germany Humanitas Research Hospital, Rozzano, MI, Italy Alma Mater Studiorum Università di Bologna, Bologna, BO, Italy ...</pre> </div></div>