According to the World Health Organization’s 2018 Global Cancer Survey, cancer is
the second leading cause of death. From this survey, the third most common is breast
cancer, the fifth is melanoma malignum and pancreatic adenocarcinoma ranks twentieth.
Undoubtedly, the early diagnosis and monitoring of these tumors and related research
is important for aspects of patient care. The aim of our present review was to explain
an impressive methodology that is deemed suitable in reference to studying blood sample
deviations in the case of solid tumors. Essentially, we compared the heat denaturation
responses of blood plasma components through differential scanning calorimetry (DSC).
In the control, between five and seven separable components can be detected, in which
the primary component was albumin, while in the case of tumorous patients, the peaks
of immunoglobulins were dominant. Moreover, the shape of the plasma DSC curves changed
with a shift in the higher temperature ranges; thus, their pattern can be used as
a suitable marker of direct immunological responses. The further development of the
analysis of DSC curves raises the possibility of the early diagnosis of a potential
tumor, the monitoring of diseases, or testing the efficacy of the therapy from a single
drop of blood.
