https://m2.mtmt.hu/ eng 2026-05-30 22:43 JournalArticle 33364842 VALIDATED true Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [KH130356, KKP126790, 2020-1.1.6-JOVo, TKP2021-EGA-33, FK-143751, KTIA_NAP_13-2014-0021, NAP2-2017-1.2.1-NKP-00002, K129065, KNN121510]; Austrian Science Fund [FWF I3522, FWF I3977, FWF I4677]; New National Excellence Program of the Ministry for Innovation and Technology of Hungary [UNKP-20-3, UNKP-21-3]; Hungarian Respiratory Society (MPA) [2020]; ILCF Young Investigator Grant; Bolyai Research Scholarship of the Hungarian Academy of Sciences; New National Excellence Program of the Minis-try for Innovation and Technology [UNKP-19-4]; Royal Physiographic Society of Lund; Mrs. Berta Kamprad's Cancer Foundation [FBKS-2020-22- (291)]; Brazilian foundation CAPES [CAPES 88887.130697]; Netherlands X-omics Initiative (NWO) [184.034.019] Funding text: This work was supported by the Hungarian National Research, Development and Innovation Office [grant numbers KH130356, KKP126790 to BD; 2020-1.1.6-JOVo} , TKP2021-EGA-33 and FK-143751 to BD and ZM; KTIA_NAP_13-2014-0021, NAP2-2017-1.2.1-NKP-00002 to J Mo and ZS; K129065 to J Mo; KNN121510 to AMS) . BD was also supported by the Austrian Science Fund [grant numbers FWF I3522, FWF I3977, FWF I4677) . ZM was supported by the UNKP-20-3 and UNKP-21-3 New National Excellence Program of the Ministry for Innovation and Technology of Hungary, and by the Hungarian Respiratory Society (MPA #2020) . ZM is recipient of the ILCF Young Investigator Grant. VL is a recipient of the Bolyai Research Scholarship of the Hungarian Academy of Sciences and the UNKP-19-4 New National Excellence Program of the Minis-try for Innovation and Technology. MR acknowledges funding from the Royal Physiographic Society of Lund and the Mrs. Berta Kamprad?s Cancer Foundation [grant number FBKS-2020-22- (291) ] . We thank the Brazilian foundation CAPES for the scholarship to NW [grant number CAPES 88887.130697] . PH was supported by the Netherlands X-omics Initiative (NWO, project number 184.034.019) . 0 false 2026-05-22T13:52:53.695+0000 2026-01-06T08:30:57.368+0000 2022-12-19T09:42:46.757+0000 true 10078148 Havas Petra /api/admin/10078148 Admin true 2026-01-23T07:29:27.501+0000 2026-01-23T07:29:27.501+0000 2026-01-06T08:30:57.581+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2023-10-04T07:54:51.165+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Woldmar, N Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases true true /api/journal/10082274 REVIEWED true false 10082274 false 10082274 true 2059-7029 2059-7029 Journal FOREIGN 8 1 100741 100741 13 2023 Background Brain metastases are associated with considerable negative effects on patients’ outcome in lung adenocarcinoma (LADC). Here, we investigated the proteomic landscape of primary LADCs and their corresponding brain metastases. Materials and methods Proteomic profiling was conducted on 20 surgically resected primary and brain metastatic LADC samples via label-free shotgun proteomics. After sample processing, peptides were analyzed using an Ultimate 3000 pump coupled to a QExactive HF-X mass spectrometer. Raw data were searched using PD 2.4. Further data analyses were carried out using Perseus, RStudio and GraphPad Prism. Proteomic data were correlated with clinical and histopathological parameters and the timing of brain metastases. Mass spectrometry-based proteomic data are available via ProteomeXchange with identifier PXD027259. Results Out of the 6821 proteins identified and quantified, 1496 proteins were differentially expressed between primary LADCs and corresponding brain metastases. Pathways associated with the immune system, cell-cell/matrix interactions and migration were predominantly activated in the primary tumors, whereas pathways related to metabolism, translation or vesicle formation were overrepresented in the metastatic tumors. When comparing fast- versus slow-progressing patients, we found 454 and 298 differentially expressed proteins in the primary tumors and brain metastases, respectively. Metabolic reprogramming and ribosomal activity were prominently up-regulated in the fast-progressing patients (versus slow-progressing individuals), whereas expression of cell-cell interaction- and immune system-related pathways was reduced in these patients and in those with multiple brain metastases. Conclusions This is the first comprehensive proteomic analysis of paired primary tumors and brain metastases of LADC patients. Our data suggest a malfunction of cellular attachment and an increase in ribosomal activity in LADC tissue, promoting brain metastasis. The current study provides insights into the biology of LADC brain metastases and, moreover, might contribute to the development of personalized follow-up strategies in LADC. Funding 2021679 /api/funding/2021679 false true Funding 2021680 /api/funding/2021680 false true Funding 2021681 /api/funding/2021681 false true Funding 2021682 /api/funding/2021682 false true Funding 2021683 /api/funding/2021683 false true Funding 2021684 /api/funding/2021684 false true Funding 2021685 /api/funding/2021685 false true Funding 2021686 /api/funding/2021686 false true Funding 2021687 /api/funding/2021687 false true Funding 2021688 /api/funding/2021688 false true Funding 2021689 /api/funding/2021689 false true Funding 2021690 /api/funding/2021690 false true Funding 2021691 /api/funding/2021691 false true Funding 2021692 /api/funding/2021692 false true true INTERNATIONAL 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.1016/j.esmoop.2022.100741 14 0 14 13 0 14 14 14 13 14 14 13 13 13 1 0 14 13 14 13 0 2 2 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 3 3 3 2024 0 3 3 3 3 2025 0 5 5 5 5 2026 0 3 2 3 2 Q1 false 10025104 false false false 2022-12-29T10:50:27.004+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Bioinformatika Tanszék (SE / AOK / I); KTIA_NAP_13 Agymetasztázis kutatócsoport (SE / AOK / I / PIBOI); Mellkassebészeti Klinika (SE / AOK / K); Országos Klinikai Idegtudományi Intézet; Országos Korányi Pulmonológiai Intézet; Országos Onkológiai Intézet; Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Patológiai, Igazságügyi és Biztosítási Orvostan... 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/api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q1 DIRECT true true /api/publication/33364842 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Woldmar N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwendenwein A<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kuras M<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074938"><a href="/gui2/?type=authors&mode=browse&sel=10074938" target="_blank">Szeitz B (<span class="authorship-author-name">Szeitz Beáta</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Boettiger K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072820"><a href="/gui2/?type=authors&mode=browse&sel=10072820" target="_blank">Tisza A (<span class="authorship-author-name">Sólyom-Tisza Anna</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037177"><a href="/gui2/?type=authors&mode=browse&sel=10037177" target="_blank">László V (<span class="authorship-author-name">László Viktória</span> <span class="authorAux-mtmt"> tumorbiologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025104"><a href="/gui2/?type=authors&mode=browse&sel=10025104" target="_blank">Reiniger L (<span class="authorship-author-name">Reiniger Lilla</span> <span class="authorAux-mtmt"> Neuropatológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Patológiai, Igazságügyi és Biztosítási Orvostani Intézet">PIBOI</span>/KTIA_NAP_13 Agymetasztázis kutatócsoport; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026954"><a href="/gui2/?type=authors&mode=browse&sel=10026954" target="_blank">Bagó A G (<span class="authorship-author-name">Bagó Attila György</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil">Országos Klinikai Idegtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068108"><a href="/gui2/?type=authors&mode=browse&sel=10068108" target="_blank">Szállási Z (<span class="authorship-author-name">Szállási Zoltán</span> <span class="authorAux-mtmt"> Onkológia, daganatkutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay J (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Patológiai, Igazságügyi és Biztosítási Orvostani Intézet">PIBOI</span>/KTIA_NAP_13 Agymetasztázis kutatócsoport; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023803"><a href="/gui2/?type=authors&mode=browse&sel=10023803" target="_blank">Szász A M (<span class="authorship-author-name">Szász Attila Marcell</span> <span class="authorAux-mtmt"> emlőpatologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Malm J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Horvatovich P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pizzatti L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Domont G B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034324"><a href="/gui2/?type=authors&mode=browse&sel=10034324" target="_blank">Rényi-Vámos F (<span class="authorship-author-name">Rényi-Vámos Ferenc István</span> <span class="authorAux-mtmt"> Mellkassebész</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoetzenecker K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoda M A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marko-Varga G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schelch K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Z (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rezeli M<sup>**</sup> ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Döme B ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery; Koranyi National Institute for Pulmonology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33364842" target="_blank">Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases</a></div> <div> <span class="journal-title">ESMO OPEN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2059-7029">2059-7029</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2059-7029">2059-7029</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 100741. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.esmoop.2022.100741" target="_blank" href="https://doi.org/10.1016/j.esmoop.2022.100741"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000901873400002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000901873400002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85144034034" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85144034034"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36527824" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36527824&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 13 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 14 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33364842&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33364842</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (KH130356), (KKP126790), (2020-1.1.6-JOVO), (TKP2021-EGA-33), (FK-143751), (KTIA_NAP_13-2014-0021), (NAP2-2017-1.2.1-NKP-00002), (K129065), (KNN121510), (ÚNKP-20-3), (UNKP-21-3), (Hungarian Respiratory Society), (János Bolyai Research Scholarship), ITM ÚNKP(UNKP-19-4) </div> <div class="lastModified">Last Modified: 2026.01.06. 09:30 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2023.10.04. 09:54 Marcell Kovács (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [KH130356, KKP126790, 2020-1.1.6-JOVo, TKP2021-EGA-33, FK-143751, KTIA_NAP_13-2014-0021, NAP2-2017-1.2.1-NKP-00002, K129065, KNN121510]; Austrian Science Fund [FWF I3522, FWF I3977, FWF I4677]; New National Excellence Program of the Ministry for Innovation and Technology of Hungary [UNKP-20-3, UNKP-2...</pre> </div></div>