Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009)
Támogató: EFOP-VEKOP
Background There are various topical and systemic treatment options for the management
of lichen planus. However, it is often difficult to achieve long-term disease control
and many of the common therapies may be associated with unwanted side effects. Aims
To evaluate the effectiveness of 8 mg oral methylprednisolone administered daily in
lichen planus by the analysis of medical records. Methods In this retrospective cohort
study, we compared the rates of improvement between two groups of patients. The first
group received 8 mg oral methylprednisolone daily for at least one month. In the second
group, patients with similar parameters to the first group (age, sex, disease manifestation)
but without systemic glucocorticoid therapy were included. Fisher's exact test was
used to compare the rates of remission in the two groups. Results In the daily oral
methylprednisolone (n = 24) and no systemic corticosteroids (n = 16) groups, 23 (95.8%)
and 6 (37.5%) patients achieved partial or complete remission, respectively. The frequency
of improvement was significantly higher in patients who received oral methylprednisolone
(P < 0.0001). Limitations Limitations of this study include its retrospective design
and the relatively small sample size. Conclusion Low dose oral glucocorticoid therapy
may be an effective option for the systemic treatment of lichen planus. Based on our
results and previous studies, instead of higher doses, longer therapy duration with
low doses should be considered.
