European Union’s Horizon 2020 research and innovation program(952491-AmReSu)
(BO/00286/22/5)
Szakterületek:
Orvosi mikrobiológia
Multiresistant Escherichia coli has been disseminated worldwide, and it is one of
the major causative agents of nosocomial infections. E. coli has a remarkable and
complex genomic plasticity for taking up and accumulating genetic elements; thus,
multiresistant high-risk clones can evolve. In this review, we summarise all available
data about internationally disseminated extraintestinal pathogenic high-risk E. coli
clones based on whole-genome sequence (WGS) data and confirmed outbreaks. Based on
genetic markers, E. coli is clustered into eight phylogenetic groups. Nowadays, the
E. coli ST131 clone from phylogenetic group B2 is the predominant high-risk clone
worldwide. Currently, strains of the C1-M27 subclade within clade C of ST131 are circulating
and becoming prominent in Canada, China, Germany, Hungary and Japan. The C1-M27 subclade
is characterised by blaCTX-M-27. Recently, the ST1193 clone has been reported as an
emerging high-risk clone from phylogenetic group B2. ST38 clone carrying blaOXA-244
(a blaOXA-48-like carbapenemase gene) caused several outbreaks in Germany and Switzerland.
Further high-risk international E. coli clones include ST10, ST69, ST73, ST405, ST410,
ST457. High-risk E. coli strains are present in different niches, in the human intestinal
tract and in animals, and persist in environment. These strains can be transmitted
easily within the community as well as in hospital settings. WGS analysis is a useful
tool for tracking the dissemination of resistance determinants, the emergence of high-risk
mulitresistant E. coli clones and to analyse changes in the E. coli population on
a genomic level.