https://m2.mtmt.hu/ eng 2026-04-30 01:50 JournalArticle 33321501 VALIDATED true Medical Centre, Department of Cardiology, Budapest, Hungary Gottsegen National Cardiovascular Center, Department of Adult Cardiology, Budapest, Hungary Szegedi Tudományegyetem (SZTE), School of Clinical Medicine, Szeged, Hungary Klinikum Passau, Department of Internal Medicine, Passau, Germany Export Date: 15 November 2025; Cited By: 12; Correspondence Address: F. Bánfi-Bacsárdi; Department of Cardiology, Medical Centre, Hungarian Defence Forces, Budapest, Hungary; email: bacsardifanni@gmail.com; CODEN: CAGYA 0 false 2026-04-22T14:20:59.452+0000 2025-11-15T15:28:49.976+0000 2022-12-12T20:27:43.371+0000 true 10078593 Muk Balázs /api/author/10078593 Author true 2026-04-22T14:15:58.239+0000 2025-02-04T19:29:31.466+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2025-11-05T07:47:50.727+0000 true 10058176 Nagyné Tari Emese /api/admin/10058176 Admin true 10058176 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bánfi-Bacsárdi, Fanni The optimization of guideline-directed medical therapy during hospitalization among patients with heart failure with reduced ejection fraction in daily clinical practice true true /api/journal/921 REVIEWED true false 921 false 921 true 0008-6312 1421-9751 Journal FOREIGN 148 1 27 37 27 11 2023 Introduction: Hospitalization due to heart failure (HF) progression is associated with poor prognosis. This highlights the role of the implementation of guideline-directed medical therapy (GDMT) in improving the morbidity and mortality of patients with heart failure with reduced ejection fraction (HFrEF). There is limited data about the intrahospital applicability of GDMT in real-world circumstances. We aimed to assess retrospectively the use of cornerstone GDMT including RASi (ACEI/ARB/ARNI), βB, MRA, and SGLT2i treatment in a consecutive real-world HFrEF patient population admitted with signs and symptoms of heart failure to the HF unit of a Hungarian tertiary cardiac centre between 2019 and 2021. The independent predictors of therapy optimization and the applicability of new HFrEF medication (ARNI, SGLT2i, vericiguat) were also investigated.Methods: Statistical comparison of admission and discharge medication was accomplished with Fisher’s exact test. The independent predictors of the introduction of triple therapy (RASi+βB+MRA) were analyzed using univariate and multivariate logistic regression. The proportion of patients eligible for vericiguat based on the inclusion and exclusion criteria of the VICTORIA trial was also investigated, as well as the number of patients suitable for ARNI and SGLT2i, taking into account the contraindications of application contained in the ESC 2021 HF Guidelines.Results: 238 patients were included. During hospitalization, the use of RASi (69% vs. 89%) (ACEI/ARBs (58% vs. 70%), ARNI (10% vs. 19%)), βBs (69% vs. 85%), and MRAs (61% vs. 95%) increased significantly (p<0.05) compared to at admission, and the use of SGLT2i (3% vs. 11%) also rose (p=0.0005). The application ratio of triple (RASi+βB+MRA; 43% vs. 77%) and quadruple (RASi+βB+MRA+SGLT2i; 2% vs. 11%) therapy increased as well (p<0.0001). The independent predictors of discharge application of triple therapy revealed through multivariate logistic regression analysis were age, duration of hospitalization, eGFR, NTproBNP, and presence of diabetes mellitus.Sixty-eight percent of the cohort would have been suitable for vericiguat, 83% for ARNI, and 84% for SGLT2i.Conclusion: High rates of application of disease-modifying drugs are achievable among hospitalized HFrEF patients in severe clinical condition, thus awareness of the need for the initiation of the former must be raised. true 2022 true true true false true false CLOSED 2026-04-22 false 12 0 12 2 10 6 12 10 12 12 12 2 2 2 10 0 12 2 12 2 0 14 14 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 0 2 0 2024 0 6 1 6 1 2025 0 4 1 4 1 Q2 false 10054440,10078593,10091214 false false false 2023-03-19T08:17:22.418+0000 Gottsegen György Országos Kardiovaszkuláris Int...; Klinikai Orvostudományi Doktori Iskola (SZTE / DI) 5 18 2 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104772407 /api/authorship/104772407 1 0.167 true false true Author 10091214 /api/author/10091214 Bánfi-Bacsárdi Fanni true true Bánfi-Bacsárdi Fanni true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104772408 /api/authorship/104772408 2 0.167 false false false Author 10078593 /api/author/10078593 Muk Balázs true true Muk Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104772409 /api/authorship/104772409 3 0.167 false false false Author 10084293 /api/author/10084293 Pilecky Dávid true true Pilecky David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104772410 /api/authorship/104772410 4 0.16666667 false false false Author 10015391 /api/author/10015391 Duray Gábor Zoltán true 10015391 true Duray Gábor Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104772411 /api/authorship/104772411 5 0.16666667 false false false Kiss Róbert Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104772412 /api/authorship/104772412 6 0.167 false true false Author 10054440 /api/author/10054440 Nyolczas Noémi true 10054440 true Nyolczas Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22268060 /api/publicationidentifier/22268060 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1159/000528505 https://doi.org/10.1159/000528505 false true PublicationIdentifier 22995904 /api/publicationidentifier/22995904 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000894222500001 https://www.webofscience.com/wos/woscc/full-record/000894222500001 true true PublicationIdentifier 23367723 /api/publicationidentifier/23367723 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85148772731 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148772731 false true PublicationIdentifier 22397500 /api/publicationidentifier/22397500 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36470212 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36470212&dopt=Abstract false true PublicationIdentifier 22268061 /api/publicationidentifier/22268061 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true https://www.karger.com/Article/FullText/528505 https://www.karger.com/Article/FullText/528505 false true PublicationIdentifier 30103306 /api/publicationidentifier/30103306 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true CLOSED IDENTICAL 38215 http://publicatio.bibl.u-szeged.hu/38215 false true SjrRating 11360976 /api/sjrrating/11360976 179 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q2 DIRECT true true /api/publication/33321501 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10091214"><a href="/gui2/?type=authors&mode=browse&sel=10091214" target="_blank">Bánfi-Bacsárdi Fanni ✉ (<span class="authorship-author-name">Bánfi-Bacsárdi Fanni</span> <span class="authorAux-mtmt"> kardiológia, szívelégtelenség</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078593"><a href="/gui2/?type=authors&mode=browse&sel=10078593" target="_blank">Muk Balázs (<span class="authorship-author-name">Muk Balázs</span> <span class="authorAux-mtmt"> kardiológia, szívelégtelenség</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Doctoral School of Clinical Medicine; Gottsegen National Cardiovascular Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084293"><a href="/gui2/?type=authors&mode=browse&sel=10084293" target="_blank">Pilecky David (<span class="authorship-author-name">Pilecky Dávid</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015391"><a href="/gui2/?type=authors&mode=browse&sel=10015391" target="_blank">Duray Gábor Zoltán (<span class="authorship-author-name">Duray Gábor Zoltán</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kiss Róbert Gábor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054440"><a href="/gui2/?type=authors&mode=browse&sel=10054440" target="_blank">Nyolczas Noémi (<span class="authorship-author-name">Nyolczas Noémi</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Doctoral School of Clinical Medicine; Gottsegen National Cardiovascular Center</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33321501" target="_blank">The optimization of guideline-directed medical therapy during hospitalization among patients with heart failure with reduced ejection fraction in daily clinical practice</a></div> <div> <span class="journal-title">CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0008-6312">0008-6312</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1421-9751">1421-9751</a>)</span>: <span class="journal-volume">148</span> <span class="journal-issue">1</span> <span class="page"> pp 27-37 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000528505" target="_blank" href="https://doi.org/10.1159/000528505"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000894222500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000894222500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85148772731" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85148772731"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36470212" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36470212&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.karger.com/Article/FullText/528505" target="_blank" href="https://www.karger.com/Article/FullText/528505"> Other URL </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:blue" title="38215" target="_blank" href="http://publicatio.bibl.u-szeged.hu/38215"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 12</span> | Independent citation: 2 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33321501&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33321501</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2025.11.15. 16:28 Márta Molnár-Taga (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Medical Centre, Department of Cardiology, Budapest, Hungary Gottsegen National Cardiovascular Center, Department of Adult Cardiology, Budapest, Hungary Szegedi Tudományegyetem (SZTE), School of Clinical Medicine, Szeged, Hungary Klinikum Passau, Department of Internal Medicine, Passau, Germany Export...</pre> </div></div>