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Both compounds were cytotoxic in a panel of six tumor lines analyzed by the MTT assay, and IC (50) values ranged from 7.8 to 45.1 mu M, including human breast adenocarcinoma (MCF-7) cells. In contrast, none of the compounds were cytotoxic on normal human peripheral blood mononuclear cells (IC (50) > 100 mu M). Human breast adenocarcinoma (MCF-7) cells treated with pacharin or bauhiniastatin-1 20 mu M for 24 h presented a reduction in cell volume and intensification of chromatin condensation, DNA fragmentation, and apoptotic cells. These findings became more evident after 48 h of exposure. Antiapoptotic B-cell lymphoma-2 family members, such as myeloid cell leukemia-1 and B-cell lymphoma-extra large, are important targets in cancer cells since their overexpression confers resistance to cancer treatments. A significant reduction of the myeloid cell leukemia-1 protein levels in human breast adenocarcinoma (MCF-7) cells after 24 h of treatment with pacharin or bauhiniastatin-1 at 20 mu M was observed, while the B-cell lymphoma-extra large protein content was reduced in bauhiniastatin-1-treated cells at 40 mu M only. The cytotoxic effects of pacharin and bauhiniastatin-1 are likely linked to myeloid cell leukemia-1 inhibition, which leads to the apoptosis of breast adenocarcinoma cells.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 300, "link" : "/api/keyword/300", "label" : "APOPTOSIS", "published" : true, "oldId" : 300, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1085750, "link" : "/api/keyword/1085750", "label" : "breast adenocarcinoma", "published" : true, "oldId" : 1085750, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1092606, "link" : "/api/keyword/1092606", "label" : "Fabaceae", "published" : true, "oldId" : 1092606, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1512705, "link" : "/api/keyword/1512705", "label" : "Mcl-1", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1519945, "link" : "/api/keyword/1519945", "label" : "Bcl-xL", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2814231, "link" : "/api/keyword/2814231", "label" : "Bauhinia acuruana", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2814232, "link" : "/api/keyword/2814232", "label" : "pacharin", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2814233, "link" : "/api/keyword/2814233", "label" : "bauhiniastatin-1", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2022, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-12-12", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11312180, "link" : "/api/sjrrating/11312180", "label" : "sjr:Q1 (2022) Scopus - Complementary and Alternative Medicine PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH 0032-0943 1439-0221", "listPos" : 19, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2707, "link" : "/api/classificationexternal/2707", "label" : "Scopus - Complementary and Alternative Medicine", "published" : true, "oldId" : 2707, "snippet" : true }, "ranking" : "Q1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 5, "ownerInstituteCount" : 11, "directInstituteCount" : 0, "authorCount" : 9, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/33321251", "label" : "Souza Silvia de et al. 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