https://m2.mtmt.hu/ hun 2026-09-20 19:23 JournalArticle 33296256 VALIDATED true Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova, 143, Barcelona, 08036, Spain Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, Barcelona, 08036, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, Barcelona, 08036, Spain Institute of Neurosciences (UBNeuro), p. de la Vall d'Hebron, 171, Barcelona, 08035, Spain CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain Department of Neuroscience, Section of Psychiatry, Catholic University of the Sacred Hearth, Roma, Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy Lucio Bini Mood Disorders Center, Cagliari, Italy Section of Psychiatry, Department of Medical Science and Public Health, University of Cagliari, Italy Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy Section of Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy Institut Clínic de Neurociències, Psychiatry and Psychology Service, Grup Recerca Addiccions Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic de Barcelona, Barcelona, Spain Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary McLean Hospital–Harvard Medical School, Boston, United States NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, Russian Federation Export Date: 16 January 2023 CODEN: JADID Correspondence Address: Vieta, E.; Bipolar and Depressive Disorders Unit, 170 Villarroel St, Catalonia, Spain; email: evieta@clinic.cat 0 false 2026-07-23T09:20:46.813+0000 2023-01-12T09:48:14.350+0000 2022-12-07T12:19:15.141+0000 true 10003491 Gonda Xénia /api/author/10003491 Author true 10003491 2026-07-23T09:19:26.362+0000 2023-01-12T09:48:14.581+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Fico, Giovanna Affective temperaments mediate aggressive dimensions in bipolar disorders A cluster analysis from a large, cross-sectional, international study true true /api/journal/2188 REVIEWED true false 2188 false 2188 true 0165-0327 1573-2517 Journal FOREIGN 323 327 335 327 9 2023 Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB.Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership.799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership.Recall bias might have affected the recollection of AB.Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB. true 2022 true true true false true false NONE 2026-07-23 false 6 0 6 3 0 6 5 6 6 6 6 3 3 3 3 0 6 3 6 3 0 8 8 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 2 1 2 1 2024 0 1 1 1 1 2025 0 2 0 2 0 2026 0 1 1 1 1 D1 B nemzetközi false false false false 2022-12-19T10:28:28.935+0000 NAP-2-SE Új Antidepresszív Gyógyszercélpont Kut... (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 1 23 2 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104599938 /api/authorship/104599938 1 0.071428575 true false false Fico Giovanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104599939 /api/authorship/104599939 2 0.071428575 false false false Janiri Delfina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104599940 /api/authorship/104599940 3 0.071428575 false false false Pinna Marco true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104599941 /api/authorship/104599941 4 0.071428575 false false false Sagué-Vilavella Maria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104599942 /api/authorship/104599942 5 0.071428575 false false false Palomo Anna Gimenez true false 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/api/ratingtype/10002 sjr true true ClassificationExternal 3203 /api/classificationexternal/3203 true 3203 true D1 DIRECT true true /api/publication/33296256 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Fico Giovanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Janiri Delfina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pinna Marco </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sagué-Vilavella Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Palomo Anna Gimenez </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oliva Vincenzo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >De Prisco Michele </span> ;&nbsp;&nbsp;&nbsp; <span 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<span class="author-name" >Vieta Eduard ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murru Andrea </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33296256" target="_blank">Affective temperaments mediate aggressive dimensions in bipolar disorders : A cluster analysis from a large, cross-sectional, international study.</a></div> <div> <span class="journal-title">JOURNAL OF AFFECTIVE DISORDERS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0165-0327">0165-0327</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-2517">1573-2517</a>)</span>: <span class="journal-volume">323</span> <span class="page"> pp 327-335 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" 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szakterülete: Scopus - Psychiatry and Mental Health&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 3 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33296256&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33296256</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2023.01.12. 10:48 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova, 143, Barcelona, 08036, Spain Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, Barcelona, 08036, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, Barce...</pre> </div></div>