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relationship between maternal factors during gestation and risk of congenital heart disease (CHD) in offspring. Methods: PubMed, EMBASE, and the Cochrane Library were searched for potentially relevant reports from inception to May 2021. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) calculated by the random-effects model were used to evaluate the association between maternal factors and CHD risk. Results: There was a significant association between CHD risk and obesity in pregnancy (OR 1.29, 95% CI 1.22–1.37; P < 0.001), smoking in pregnancy (OR 1.16, 95% CI 1.07–1.25; P < 0.001), maternal diabetes (OR 2.65, 95% CI 2.20–3.19; P < 0.001), and exposure of pregnant women to organic solvents (OR 1.82, 95% CI 1.23–2.70; P = 0.003). No correlations were revealed between CHD susceptibility and advanced maternal age (OR 1.04, 95% CI 0.96–1.12; P = 0.328), underweight (OR 1.02, 95% CI 0.96–1.08; P = 0.519), alcohol intake in pregnancy (OR 1.08, 95% CI 0.95–1.22; P = 0.251), coffee intake (OR 1.18, 95% CI 0.97–1.44; P = 0.105), and exposure to irradiation (OR 1.80, 95% CI 0.85–3.80; P = 0.125). Discussion: Maternal factors including maternal obesity, smoking in pregnancy, maternal diabetes and exposure to organic solvents might predispose the offspring to CHD risk. © 2022, The Author(s).", "keywords" : [ { "otype" : "Keyword", "mtid" : 6820, "link" : "/api/keyword/6820", "label" : "pregnancy", "published" : true, "oldId" : 6820, "snippet" : true }, { "otype" : "Keyword", "mtid" : 13575, "link" : "/api/keyword/13575", "label" : "Meta-analysis", "published" : true, "oldId" : 13575, "snippet" : true }, { "otype" : "Keyword", "mtid" : 19862, "link" : "/api/keyword/19862", "label" : "systematic review", "published" : true, "oldId" : 19862, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1143545, "link" : "/api/keyword/1143545", "label" : "Congenital heart defects", "published" : true, "oldId" : 1143545, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1503017, "link" : "/api/keyword/1503017", "label" : "Offspring", "published" : true, "snippet" : true } ], "digital" : true, "printed" : true, "sourceYear" : 2022, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : false, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-05-28", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11405622, "link" : "/api/sjrrating/11405622", "label" : "sjr:Q1 (2023) Scopus - Pediatrics, Perinatology and Child Health MATERNAL AND CHILD HEALTH JOURNAL 1092-7875 1573-6628", "listPos" : 69, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2735, "link" : "/api/classificationexternal/2735", "label" : "Scopus - Pediatrics, Perinatology and Child Health", "published" : true, "oldId" : 2735, "snippet" : true }, "ranking" : "Q1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "references" : [ { "otype" : "Reference", "mtid" : 36355637, "link" : "/api/reference/36355637", "label" : "1. 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