https://m2.mtmt.hu/ hun 2026-09-20 23:13 JournalArticle 33291618 VALIDATED true Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary North West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester, M23 9LT, United Kingdom Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, M13 9NT, United Kingdom Institute of Pulmonology, Torokbalint, 2045, Hungary Cited By :1 Export Date: 20 July 2023 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Funding details: Manchester Biomedical Research Centre, BRC Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-5 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Magyarország Kormánya, OTKA 138055 Funding details: Innovációs és Technológiai Minisztérium Funding details: Magyar Tüdőgyógyász Társaság, MTT Funding text 1: This research was funded by the Semmelweis Science and Innovation Fund—Research and Development Application; Hungarian Respiratory Society—Scientific Research Application; Dean’s Fund—Research Application between Theoretical and Clinical Institutes; Bólyai scholarship of the Hungarian Academy of Sciences; ÚNKP-20-5 and ÚNKP-21-5 New National Excellence Program of the Ministry for Innovation and Technology, from the source of the National Research, Development, and Innovation Fund. The bioinformatics analysis was supported by the Hungarian Government grant OTKA 138055 (Large scale surveying of bacteriophages in the human microbiome with pangenomic and machine learning approaches). Funding text 2: The Samsung ultrasound equipment was provided by Sonarmed Ltd., a Samsung Medison representative. Colleagues of the Medical Imaging Centre and Institute of Medical Microbiology, Semmelweis University, provided administrative and technical support. The authors are grateful to Electro-oxygen for providing equipment for this study and Monika Banlaky for her support with the sleep tests as well as Peter Fussy and Szonja Galyasz for their help during the microbiome measurements, and Bianka Forgo, Marcell Szily and Daniel Tamas Kovacs for their help in the OSA study. Andras Bikov is supported by the NIHR Manchester BRC. 0 false 2026-08-31T11:21:29.110+0000 2026-01-26T11:15:34.454+0000 2022-12-05T00:30:14.252+0000 true 10023975 Bikov András /api/author/10023975 Author true 10023975 2026-03-24T16:41:55.682+0000 2022-12-14T12:03:17.388+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabo, Helga The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea true true /api/journal/10039908 REVIEWED true false 10039908 false 10039908 true 2076-3417 Journal FOREIGN 12 22 11484 11484 18 2022 Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample. Funding 2021282 /api/funding/2021282 false true Funding 2021283 /api/funding/2021283 false true Funding 2021284 /api/funding/2021284 false true Funding 2021285 /api/funding/2021285 false true Funding 2021286 /api/funding/2021286 false true Funding 2021287 /api/funding/2021287 false true true 2022 true true true false true false GOLD 2026-08-31 true https://doi.org/10.3390/app122211484 10 0 10 9 1 10 10 10 9 10 10 9 9 9 1 0 10 9 10 9 0 6 6 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák 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/api/authorship/104574767 3 0.083 false false false Author 10061218 /api/author/10061218 Hernyes Anita true 10061218 true Hernyes Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574768 /api/authorship/104574768 4 0.083 false false false Author 10085413 /api/author/10085413 Zöldi Luca true true Zoldi Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574769 /api/authorship/104574769 5 0.083 false false false Author 10049994 /api/author/10049994 Juhász János true 10049994 true Juhasz Janos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574770 /api/authorship/104574770 6 0.083333336 false false false Author 10034554 /api/author/10034554 Ligeti Balázs true 10034554 true Ligeti Balazs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574771 /api/authorship/104574771 7 0.083 false false false Author 10034793 /api/author/10034793 Makra Nóra true 10034793 true Makra Nora true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574772 /api/authorship/104574772 8 0.083 false false false Author 10003357 /api/author/10003357 Szabó Dóra true 10003357 true Szabo Dora true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574773 /api/authorship/104574773 9 0.083333336 false false false Author 10023975 /api/author/10023975 Bikov András true 10023975 true Bikov Andras true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574774 /api/authorship/104574774 10 0.083333336 false false false Kunos Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574775 /api/authorship/104574775 11 0.083 false false false Author 10023716 /api/author/10023716 Tárnoki Ádám Domonkos true 10023716 true Tarnoki Adam Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104574776 /api/authorship/104574776 12 0.083 false true true Author 10023718 /api/author/10023718 Tárnoki Dávid László true 10023718 true Tarnoki David Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22193947 /api/publicationidentifier/22193947 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/app122211484 https://doi.org/10.3390/app122211484 false true PublicationIdentifier 22193948 /api/publicationidentifier/22193948 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000887034500001 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<div class="autype autype0"> <span class="author-name" mtid="10072148"><a href="/gui2/?type=authors&mode=browse&sel=10072148" target="_blank">Szabo Helga (<span class="authorship-author-name">Szabó Helga</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070362"><a href="/gui2/?type=authors&mode=browse&sel=10070362" target="_blank">Piroska Marton (<span class="authorship-author-name">Piroska Márton</span> <span class="authorAux-mtmt"> Radiológia, Nukleáris Medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061218"><a href="/gui2/?type=authors&mode=browse&sel=10061218" target="_blank">Hernyes Anita (<span class="authorship-author-name">Hernyes Anita</span> <span class="authorAux-mtmt"> radiológia/elméleti orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085413"><a href="/gui2/?type=authors&mode=browse&sel=10085413" target="_blank">Zoldi Luca (<span class="authorship-author-name">Zöldi Luca</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049994"><a href="/gui2/?type=authors&mode=browse&sel=10049994" target="_blank">Juhasz Janos (<span class="authorship-author-name">Juhász János</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet; <span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034554"><a href="/gui2/?type=authors&mode=browse&sel=10034554" target="_blank">Ligeti Balazs (<span class="authorship-author-name">Ligeti Balázs</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034793"><a href="/gui2/?type=authors&mode=browse&sel=10034793" target="_blank">Makra Nora (<span class="authorship-author-name">Makra Nóra</span> <span class="authorAux-mtmt"> genomika, biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003357"><a href="/gui2/?type=authors&mode=browse&sel=10003357" target="_blank">Szabo Dora (<span class="authorship-author-name">Szabó Dóra</span> <span class="authorAux-mtmt"> Mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023975"><a href="/gui2/?type=authors&mode=browse&sel=10023975" target="_blank">Bikov Andras (<span class="authorship-author-name">Bikov András</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kunos Laszlo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023716"><a href="/gui2/?type=authors&mode=browse&sel=10023716" target="_blank">Tarnoki Adam Domonkos (<span class="authorship-author-name">Tárnoki Ádám Domonkos</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023718"><a href="/gui2/?type=authors&mode=browse&sel=10023718" target="_blank">Tarnoki David Laszlo ✉ (<span class="authorship-author-name">Tárnoki Dávid László</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Orvosi Képalkotó Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33291618" target="_blank">The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea</a></div> <div> <span class="journal-title">APPLIED SCIENCES-BASEL</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-3417">2076-3417</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">22</span> <span class="page"> Paper 11484. 18 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/app122211484" target="_blank" href="https://doi.org/10.3390/app122211484"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000887034500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000887034500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85142801346" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85142801346"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Fluid Flow and Transfer Processes&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Instrumentation&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Materials Science (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Process Chemistry and Technology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 9 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33291618&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33291618</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (Semmelweis Science and Innovation Fund), (Hungarian Respiratory Society), (János Bolyai Research Scholarship), (UNKP-20-5), (ÚNKP-21-5), OTKA(138055) </div> <div class="lastModified">Utolsó módosítás: 2026.01.26. 12:15 Pirmann Tamás (OOI admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Ca...</pre> </div></div>