https://m2.mtmt.hu/ hun 2026-05-31 15:43 JournalArticle 33283844 VALIDATED true Export Date: 20 January 2023 0 false 2026-05-22T12:34:42.503+0000 2022-12-14T09:16:48.991+0000 2022-11-29T18:05:22.933+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2026-03-27T10:20:24.907+0000 2026-03-27T10:20:24.907+0000 2022-12-14T09:16:49.001+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2023-06-05T15:04:38.794+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Efentakis, Panagiotis Myocardial Protection and Current Cancer Therapy: Two Opposite Targets with Inevitable Cost true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 23 22 14121 14121 39 2022 Myocardial protection against ischemia/reperfusion injury (IRI) is mediated by various ligands, activating different cellular signaling cascades. These include classical cytosolic mediators such as cyclic-GMP (c-GMP), various kinases such as Phosphatydilinositol-3- (PI3K), Protein Kinase B (Akt), Mitogen-Activated-Protein- (MAPK) and AMP-activated (AMPK) kinases, transcription factors such as signal transducer and activator of transcription 3 (STAT3) and bioactive molecules such as vascular endothelial growth factor (VEGF). Most of the aforementioned signaling molecules constitute targets of anticancer therapy; as they are also involved in carcinogenesis, most of the current anti-neoplastic drugs lead to concomitant weakening or even complete abrogation of myocardial cell tolerance to ischemic or oxidative stress. Furthermore, many anti-neoplastic drugs may directly induce cardiotoxicity via their pharmacological effects, or indirectly via their cardiovascular side effects. The combination of direct drug cardiotoxicity, indirect cardiovascular side effects and neutralization of the cardioprotective defense mechanisms of the heart by prolonged cancer treatment may induce long-term ventricular dysfunction, or even clinically manifested heart failure. We present a narrative review of three therapeutic interventions, namely VEGF, proteasome and Immune Checkpoint inhibitors, having opposing effects on the same intracellular signal cascades thereby affecting the heart. Moreover, we herein comment on the current guidelines for managing cardiotoxicity in the clinical setting and on the role of cardiovascular confounders in cardiotoxicity. Funding 2021258 /api/funding/2021258 false true Funding 2021259 /api/funding/2021259 false true true 2022 true true true false true false GOLD 2026-05-22 true https://doi.org/10.3390/ijms232214121 18 0 17 12 2 17 17 15 14 17 17 12 12 13 5 0 18 13 17 12 0 10 10 Folyóiratcikk Journal Article 24 17 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 3 3 3 3 2024 0 8 3 8 3 2025 0 5 5 5 5 2026 0 2 2 2 2 D1 false false false false 2022-12-13T09:16:48.793+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 1 15 1 7 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104539500 /api/authorship/104539500 1 0.14285715 true false false Efentakis Panagiotis true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539501 /api/authorship/104539501 2 0.143 false false true Andreadou Ioanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539502 /api/authorship/104539502 3 0.14285715 false false false Iliodromitis Konstantinos E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539503 /api/authorship/104539503 4 0.14285715 false false false Triposkiadis Filippos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539504 /api/authorship/104539504 5 0.143 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539505 /api/authorship/104539505 6 0.14285715 false false false Schulz Rainer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104539506 /api/authorship/104539506 7 0.14285715 false true false Iliodromitis Efstathios K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22176621 /api/publicationidentifier/22176621 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms232214121 https://doi.org/10.3390/ijms232214121 false true PublicationIdentifier 22292043 /api/publicationidentifier/22292043 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000887452000001 https://www.webofscience.com/wos/woscc/full-record/000887452000001 true true PublicationIdentifier 22292034 /api/publicationidentifier/22292034 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85142940684 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85142940684 true true PublicationIdentifier 22176622 /api/publicationidentifier/22176622 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36430599 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36430599&dopt=Abstract false true Classification 12197 /api/classification/12197 true true SjrRating 11289558 /api/sjrrating/11289558 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true /api/publication/33283844 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Efentakis Panagiotis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Andreadou Ioanna ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Iliodromitis Konstantinos E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Triposkiadis Filippos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Iliodromitis Efstathios K. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33283844" target="_blank">Myocardial Protection and Current Cancer Therapy: Two Opposite Targets with Inevitable Cost</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">22</span> <span class="page"> Paper 14121. 39 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms232214121" target="_blank" href="https://doi.org/10.3390/ijms232214121"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000887452000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000887452000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85142940684" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85142940684"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36430599" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36430599&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 18</span> | Független: 13 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 15 | Scopus jelölt:&nbsp;14 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33283844&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33283844</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (Therapeutic Development Thematic Programme of the Semmelweis University), (RRF-2.3.1-21-2022-00003) </div> <div class="lastModified">Utolsó módosítás: 2022.12.14. 10:16 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2023.06.05. 17:04 Pécsi Éva (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 20 January 2023</pre> </div></div>