https://m2.mtmt.hu/ eng 2026-09-21 13:32 JournalArticle 33262434 VALIDATED true Institute of Molecular Biomedicine, Medical Faculty, Comenius University, Bratislava, 811 07, Slovakia Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, 6200 MD, Netherlands Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, 813 72, Slovakia Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, 1089, Hungary Cited By :6 Export Date: 6 February 2024 Correspondence Address: Šebeková, K.; Institute of Molecular Biomedicine, Slovakia; email: kata.sebekova@gmail.com 0 false 2026-07-10T09:42:12.684+0000 2023-01-10T10:23:08.300+0000 2022-11-22T17:13:52.865+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Gizella Áncsán (SE admin) true 10015206 2026-07-10T09:40:57.169+0000 2022-12-05T09:29:57.062+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Csongová, Melinda true true /api/journal/10016563 REVIEWED NUTRIENTS 2072-6643 true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 14 22 4929 4929 14 2022 α-Dicarbonyls and advanced glycation end products (AGEs) may contribute to the pathogenesis of insulin resistance by a variety of mechanisms. To investigate whether young insulin-resistant subjects present markers of increased dicarbonyl stress, we determined serum α-dicarbonyls-methylglyoxal, glyoxal, 3-deoxyglucosone; their derived free- and protein-bound, and urinary AGEs using the UPLC/MS-MS method; soluble receptors for AGEs (sRAGE), and cardiometabolic risk markers in 142 (49% females) insulin resistant (Quantitative Insulin Sensitivity Check Index (QUICKI) ≤ 0.319) and 167 (47% females) age-, and waist-to-height ratio-matched insulin-sensitive controls aged 16-to-22 years. The between-group comparison was performed using the two-factor (sex, presence/absence of insulin resistance) analysis of variance; multiple regression via the orthogonal projection to latent structures model. In comparison with their insulin-sensitive peers, young healthy insulin-resistant individuals without diabetes manifest alterations throughout the α-dicarbonyls-AGEs-sRAGE axis, dominated by higher 3-deoxyglucosone levels. Variables of α-dicarbonyls-AGEs-sRAGE axis were associated with insulin sensitivity independently from cardiometabolic risk markers, and sex-specifically. Cleaved RAGE associates with QUICKI only in males; while multiple α-dicarbonyls and AGEs independently associate with QUICKI particularly in females, who displayed a more advantageous cardiometabolic profile compared with males. Further studies are needed to elucidate whether interventions alleviating dicarbonyl stress ameliorate insulin resistance. true 2022 true true true false true false GOLD 2026-07-10 true https://doi.org/10.3390/nu14224929 11 0 11 9 0 11 11 11 6 11 11 9 9 9 2 0 11 9 11 9 0 2 2 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 4 3 4 3 2024 0 2 2 2 2 2025 0 3 2 3 2 2026 0 2 2 2 2 D1 false false false false 2022-12-04T09:29:56.732+0000 Gyógyszerhatástani Intézet (SE / GYTK) 2 7 1 9 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 104420469 /api/authorship/104420469 Csongová, Melinda 1 0.11111111 true false false Csongová Melinda true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420470 /api/authorship/104420470 Scheijen, Jean L. J. M. 2 0.11111111 false false false Scheijen Jean L. J. M. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420471 /api/authorship/104420471 van de Waarenburg, Marjo P. H. 3 0.11111111 false false false van de Waarenburg Marjo P. H. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420472 /api/authorship/104420472 Gurecká, Radana 4 0.11111111 false false false Gurecká Radana true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420473 /api/authorship/104420473 Koborová, Ivana 5 0.11111111 false false false Koborová Ivana true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420474 /api/authorship/104420474 Tábi, Tamás [Tábi, Tamás (Farmakológia), author] Department of Pharmacodynamics (SU / FP) 6 0.111 false false false Author 10012548 /api/author/10012548 Tamás Tábi (Farmakológia) Tábi Tamás true 10012548 true Tábi Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420475 /api/authorship/104420475 Szökö, Éva [Szökő, Éva (Farmakológia, gyó...), author] Department of Pharmacodynamics (SU / FP) 7 0.111 false false false Author 10003174 /api/author/10003174 Éva Szökő (Farmakológia, gyógyszeranalitika) Szökő Éva true 10003174 true Szökö Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420476 /api/authorship/104420476 Schalkwijk, Casper G. 8 0.11111111 false false false Schalkwijk Casper G. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 104420477 /api/authorship/104420477 Šebeková, Katarína ✉ 9 0.111 false true true Šebeková Katarína true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 22132516 /api/publicationidentifier/22132516 DOI: 10.3390/nu14224929 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/nu14224929 https://doi.org/10.3390/nu14224929 false true PublicationIdentifier 22316326 /api/publicationidentifier/22316326 WoS: 000887570300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000887570300001 https://www.webofscience.com/wos/woscc/full-record/000887570300001 false true PublicationIdentifier 22194646 /api/publicationidentifier/22194646 Scopus: 85142632277 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85142632277 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85142632277 true true PublicationIdentifier 22194647 /api/publicationidentifier/22194647 PubMed: 36432614 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 36432614 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36432614&dopt=Abstract true true PublicationIdentifier 22813004 /api/publicationidentifier/22813004 Google scholar: 7810193603594908416 PlainSource 12 /api/publicationsource/12 Google scholar PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Google scholar http://scholar.Google.com/scholar?hl=en&lr=&cluster=@@@ true true 12 true IDENTICAL 7810193603594908416 http://scholar.Google.com/scholar?hl=en&lr=&cluster=7810193603594908416 true true SjrRating 11274633 /api/sjrrating/11274633 sjr:D1 (2022) Scopus - Food Science NUTRIENTS 2072-6643 20 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 Scopus - Food Science true 1106 true D1 DIRECT true true Reference 35980114 /api/reference/35980114 1. 2015: Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease?., Curr. 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Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin and Metalloproteinase 10 in Type 1 Diabetes. PLoS ONE, 10., DOI: 10.1371/journal.pone.0137330 67 10.1371/journal.pone.0137330 false true /api/publication/33262434 Csongová Melinda et al. Association of α-Dicarbonyls and Advanced Glycation End Products with Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study. (2022) NUTRIENTS 2072-6643 14 22<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Csongová Melinda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scheijen Jean L. J. M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van de Waarenburg Marjo P. H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gurecká Radana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Koborová Ivana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012548"><a href="/gui2/?type=authors&mode=browse&sel=10012548" target="_blank">Tábi Tamás (<span class="authorship-author-name">Tábi Tamás</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003174"><a href="/gui2/?type=authors&mode=browse&sel=10003174" target="_blank">Szökö Éva (<span class="authorship-author-name">Szökő Éva</span> <span class="authorAux-mtmt"> Farmakológia, gyógyszeranalitika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schalkwijk Casper G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Šebeková Katarína ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33262434" target="_blank">Association of α-Dicarbonyls and Advanced Glycation End Products with Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">22</span> <span class="page"> Paper 4929. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nu14224929" target="_blank" href="https://doi.org/10.3390/nu14224929"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000887570300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000887570300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85142632277" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85142632277"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36432614" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36432614&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="7810193603594908416" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=7810193603594908416"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Food Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 9 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33262434&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33262434</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2023.01.10. 11:23 Ágnes Ruzsits (SE_GYTK_Gyhatástan_Admin5_RÁ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Molecular Biomedicine, Medical Faculty, Comenius University, Bratislava, 811 07, Slovakia Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, 6200 MD, Netherlands Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, 813 72, Slovakia...</pre> </div></div>