https://m2.mtmt.hu/ hun 2026-09-20 21:08 JournalArticle 33261135 VALIDATED true 0 false 2026-07-14T07:48:23.610+0000 2023-01-22T16:34:22.169+0000 2022-11-22T10:49:57.679+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2023-01-22T16:34:09.714+0000 2023-01-22T16:34:09.714+0000 2023-01-22T16:34:22.181+0000 true 10074555 Molnár-Taga Márta /api/admin/10074555 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Tarcsai, Katalin Réka SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 44 5 2337 2345 2337 9 2022 A new variant of SARS-CoV-2 named Omicron (B.1.1.529) was isolated from an HIV-infected patient in Botswana, South Africa, in November 2021. Whole genome sequencing revealed a multitude of mutations and its relationship to the mutation-rich Alpha variant that had been isolated from a cancer patient. It is conceivable that very high prevalence of HIV-infected individuals as susceptible hosts in South Africa and their immunocompromised state may predispose for accumulation of coronavirus mutations. Coronaviruses uniquely code for an N-terminal 3′ to 5′exonuclease (ExoN, nsp14) that removes mismatched nucleotides paired by the RNA dependent RNA polymerase. Its activity depends preferably on Mg2+ and other divalent cations (manganese, cobalt and zinc). On the contrary, methyl transferase activity of non-structural protein (nsp) 14 and nsp16 both complexed with nsp10 requires Mn2+. Enzymes in successive stages of HIV infections require the same cations. In HIV-infected organisms, a subsequent coronavirus infection encounters with altered homeostasis of the body including relative starvation of divalent cations induced by interleukin production of HIV-infected cells. It is hypothesized that selective diminished efficacy of ExoN in the absence of sufficient amount of magnesium may result in the accumulation of mutations. Unusual mutations and recombinations of heterologous viruses detected in AIDS patients also suggest that long-lasting persistence of superinfecting viruses may also contribute to the selection of genetic variants. Non-nucleoside reverse transcriptase inhibitors partially restore divalent cations’ equilibrium. As a practical approach, implementation of highly active antiretroviral therapy against HIV replication and vaccination against coronaviruses may be a successful strategy to reduce the risk of selection of similar mutants. Funding 2020516 /api/funding/2020516 false true Funding 2020517 /api/funding/2020517 false true true true 2022 true true true false true false NONE 2026-07-14 false 17 0 17 17 0 17 16 12 17 17 17 17 17 17 0 0 17 17 17 17 0 0 0 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 1 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2022 0 1 1 1 1 2023 0 5 5 5 5 2024 0 9 9 9 9 2025 0 1 1 1 1 2026 0 1 1 1 1 D1 false false false false 2023-01-21T16:34:21.971+0000 Doktori Iskola (SE); Népegészségtani Intézet (SE / AOK / I); Transzfúziológiai Tanszék (SE / AOK / K) 4 14 3 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 104411959 /api/authorship/104411959 1 0.25 true false false Author 10062722 /api/author/10062722 Tarcsai Katalin Réka true 10062722 true Tarcsai Katalin Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104411960 /api/authorship/104411960 2 0.25 true false false Author 10083363 /api/author/10083363 Corolciuc Oliga true true Corolciuc Oliga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104411961 /api/authorship/104411961 3 0.25 false false false Author 10002439 /api/author/10002439 Tordai Attila true 10002439 true Tordai Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104411962 /api/authorship/104411962 4 0.25 false true true Author 10001375 /api/author/10001375 Ongrádi József true 10001375 true Ongrádi József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22129133 /api/publicationidentifier/22129133 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE 10.1007/s11357-022-00603-6 https://doi.org/10.1007/s11357-022-00603-6 false true PublicationIdentifier 22419582 /api/publicationidentifier/22419582 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000814968300001 https://www.webofscience.com/wos/woscc/full-record/000814968300001 false true PublicationIdentifier 22129134 /api/publicationidentifier/22129134 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 85132570540 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132570540 false true SjrRating 11312161 /api/sjrrating/11312161 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2707 /api/classificationexternal/2707 true 2707 true D1 DIRECT true true /api/publication/33261135 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062722"><a href="/gui2/?type=authors&mode=browse&sel=10062722" target="_blank">Tarcsai Katalin Réka (<span class="authorship-author-name">Tarcsai Katalin Réka</span> <span class="authorAux-mtmt"> Virológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083363"><a href="/gui2/?type=authors&mode=browse&sel=10083363" target="_blank">Corolciuc Oliga<sup>*</sup> (<span class="authorship-author-name">Corolciuc Oliga</span> <span class="authorAux-mtmt"> Orvostudomány (Herpes and Adenoviruses)</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Transzfúziológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002439"><a href="/gui2/?type=authors&mode=browse&sel=10002439" target="_blank">Tordai Attila (<span class="authorship-author-name">Tordai Attila</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Transzfúziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001375"><a href="/gui2/?type=authors&mode=browse&sel=10001375" target="_blank">Ongrádi József ✉ (<span class="authorship-author-name">Ongrádi József</span> <span class="authorAux-mtmt"> Mikrobiológia, virológia, közegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Transzfúziológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33261135" target="_blank">SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">44</span> <span class="journal-issue">5</span> <span class="page"> pp 2337-2345 </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:black" title="10.1007/s11357-022-00603-6" target="_blank" href="https://doi.org/10.1007/s11357-022-00603-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000814968300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000814968300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85132570540" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85132570540"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 17 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;17 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;16 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33261135</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (Semmelweis University Start-up Grant (No. 11725)) </div> <div class="lastModified">Utolsó módosítás: 2023.01.22. 17:34 Molnár-Taga Márta (SE_AOK_Negegeszsegtan_Admin5_MTM, admin) </div> </div></div>