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Its catastrophic breakup (similar to 150 years; 11.3-11.2 cal ka BP) coincided with a rapidly warming atmosphere and ocean, paralleling reported conditions impacting the ongoing evolution of marine-based margins of Antarctica and Greenland. Our record highlights the instability of the NW Laurentide Ice Sheet whose marine-based ice streams and ice shelves retreated in channels of intermediate depth (400-600 m) that lack reverse slopes, suggesting that current ice dynamics models may underestimate the sensitivity of similar margins in Antarctica to ongoing global warming. Our reconstruction is based on > 700 km of coastal field surveys complemented by radiocarbon dates stratigraphically encompassing the full lifespan of the former Viscount Melville Sound Ice Shelf. Notably, this detailed record demonstrates that large ice shelves can be removed rapidly, cautioning against dismissing predictions of possible 21st century mean-sea-level rise >1 m derived from the ongoing retreat of marine-based ice sheets. We emphasize that during the last deglaciation of the western Canadian Arctic Archipelago, prominent ice streams transitioned into ice shelves whose depositional landforms are pervasive, demonstrating their pivotal role in the evisceration of the NW Laurentide Ice Sheet. The VMSIS provides an exceptionally detailed geological record whose tightly constrained chronology of growth, maintenance and breakup serves as an instructive example for those modern marine-based margins whose instability is being investigated to address estimates of possible future sea level rise. 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