https://m2.mtmt.hu/ eng 2026-10-22 22:02 JournalArticle 33231081 VALIDATED true Funding Agency and Grant Number: Crinetics Pharmaceuticals Inc. Funding text: This work was supported by Crinetics Pharmaceuticals Inc. The manuscript was written independently by the authors with medical writing support, which was funded by Crinetics Pharmaceuticals Inc and provided by Autumn Kelly, MA, and Donna Simcoe, MS, MS, MBA, CMPP, of Simcoe Consultants, Inc. 0 false 2026-10-13T12:53:50.610+0000 2026-01-15T09:07:48.213+0000 2022-11-14T11:03:04.977+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-01-15T09:07:48.111+0000 2024-11-28T06:02:47.520+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gadelha, Monica R ACROBAT Edge : Safety and efficacy of switching injected SRLs to oral paltusotine in patients with acromegaly true true /api/journal/10030700 REVIEWED true false 10030700 false 10030700 true 0021-972X 1945-7197 Journal FOREIGN 108 5 e148 e159 e148 2023 Paltusotine is a once-daily, oral, non-peptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly.To evaluate change in IGF-I levels in patients switched from octreotide LAR or lanreotide depot monotherapy to paltusotine.Phase 2, open-label, prospective, multicenter, multinational, non-randomized, single-arm exploratory study in which dosage up-titrations were performed in a double-blinded manner.26 global sites.Patients with acromegaly switched to paltusotine from injected SRL-based therapy.Patients received 13-week treatment with once-daily oral paltusotine (10-40 mg/day).Primary endpoint was change from baseline to week 13 in IGF-I for patients who switched from long-acting octreotide or lanreotide monotherapy to paltusotine (Group 1). All patients underwent a 4-week paltusotine washout at end of treatment period (weeks 13-17). IGF-I, GH, patient reported outcome, and safety data were collected.Forty-seven patients enrolled. In Group 1 (n = 25), IGF-I and GH showed no significant change between SRL baseline and end of paltusotine treatment at week 13 (median change in IGF-I = -0.03×upper limit of normal [ULN], P = 0.6285; GH = -0.05 ng/mL, P = 0.6285). IGF-I and GH rose significantly in the 4 weeks after withdrawing paltusotine (median change in IGF-I = 0.55×ULN, P < 0.0001 [median increase 39%]; GH = 0.72 ng/mL, P < 0.0001 [109.1% increase]). No patients discontinued due to adverse events; no treatment-related serious adverse events were reported.These results suggest once daily, oral paltusotine is effective in maintaining IGF-I values in patients with acromegaly who switched from injected SRLs. 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Gadelha Monica R ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gordon Murray B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doknic Mirjana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012397"><a href="/gui2/?type=authors&mode=browse&sel=10012397" target="_blank">Mezősi Emese (<span class="authorship-author-name">Mezősi Emese</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/1st Department of Internal Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Tóth Miklós (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Randeva Harpal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marmon Tonya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jochelson Theresa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Luo Rosa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Monahan Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Madan Ajay </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ferrara-Cook Christine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Struthers R Scott </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krasner Alan </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33231081" target="_blank">ACROBAT Edge : Safety and efficacy of switching injected SRLs to oral paltusotine in patients with acromegaly</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-972X">0021-972X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7197">1945-7197</a>)</span>: <span class="journal-volume">108</span> <span class="journal-issue">5</span> <span class="page"> pp e148-e159 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1210/clinem/dgac643" target="_blank" href="https://doi.org/10.1210/clinem/dgac643"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000897934300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000897934300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85143863023" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85143863023"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36353760" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36353760&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 44</span> | Independent citation: 34 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 36 | Number of citations in Scopus:&nbsp;39 | WoS/Scopus assigned:&nbsp;40 | Number of citations with DOI:&nbsp;44 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33231081&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 33231081</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2026.01.15. 10:07 Gizella Áncsán (SE admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Crinetics Pharmaceuticals Inc. Funding text: This work was supported by Crinetics Pharmaceuticals Inc. The manuscript was written independently by the authors with medical writing support, which was funded by Crinetics Pharmaceuticals Inc and provided by Autumn Kelly, MA, and Donna Simcoe, MS, MS, MBA, CMPP, of Simcoe Consultants, Inc.</pre> </div></div>