https://m2.mtmt.hu/ hun 2026-09-22 12:50 JournalArticle 33231081 VALIDATED true Funding Agency and Grant Number: Crinetics Pharmaceuticals Inc. Funding text: This work was supported by Crinetics Pharmaceuticals Inc. The manuscript was written independently by the authors with medical writing support, which was funded by Crinetics Pharmaceuticals Inc and provided by Autumn Kelly, MA, and Donna Simcoe, MS, MS, MBA, CMPP, of Simcoe Consultants, Inc. 0 false 2026-09-20T08:47:05.439+0000 2026-01-15T09:07:48.213+0000 2022-11-14T11:03:04.977+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-01-15T09:07:48.111+0000 2024-11-28T06:02:47.520+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gadelha, Monica R ACROBAT Edge : Safety and efficacy of switching injected SRLs to oral paltusotine in patients with acromegaly true true /api/journal/10030700 REVIEWED true false 10030700 false 10030700 true 0021-972X 1945-7197 Journal FOREIGN 108 5 e148 e159 e148 2023 Paltusotine is a once-daily, oral, non-peptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly.To evaluate change in IGF-I levels in patients switched from octreotide LAR or lanreotide depot monotherapy to paltusotine.Phase 2, open-label, prospective, multicenter, multinational, non-randomized, single-arm exploratory study in which dosage up-titrations were performed in a double-blinded manner.26 global sites.Patients with acromegaly switched to paltusotine from injected SRL-based therapy.Patients received 13-week treatment with once-daily oral paltusotine (10-40 mg/day).Primary endpoint was change from baseline to week 13 in IGF-I for patients who switched from long-acting octreotide or lanreotide monotherapy to paltusotine (Group 1). All patients underwent a 4-week paltusotine washout at end of treatment period (weeks 13-17). IGF-I, GH, patient reported outcome, and safety data were collected.Forty-seven patients enrolled. In Group 1 (n = 25), IGF-I and GH showed no significant change between SRL baseline and end of paltusotine treatment at week 13 (median change in IGF-I = -0.03×upper limit of normal [ULN], P = 0.6285; GH = -0.05 ng/mL, P = 0.6285). IGF-I and GH rose significantly in the 4 weeks after withdrawing paltusotine (median change in IGF-I = 0.55×ULN, P < 0.0001 [median increase 39%]; GH = 0.72 ng/mL, P < 0.0001 [109.1% increase]). No patients discontinued due to adverse events; no treatment-related serious adverse events were reported.These results suggest once daily, oral paltusotine is effective in maintaining IGF-I values in patients with acromegaly who switched from injected SRLs. 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/api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104236111 /api/authorship/104236111 11 0.071428575 false false false Madan Ajay true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104236112 /api/authorship/104236112 12 0.071428575 false false false Ferrara-Cook Christine true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104236113 /api/authorship/104236113 13 0.071428575 false false false Struthers R Scott true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 104236114 /api/authorship/104236114 14 0.071428575 false true false Krasner Alan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 22052487 /api/publicationidentifier/22052487 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 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class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Gadelha Monica R ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gordon Murray B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doknic Mirjana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012397"><a href="/gui2/?type=authors&mode=browse&sel=10012397" target="_blank">Mezősi Emese (<span class="authorship-author-name">Mezősi Emese</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Tóth Miklós (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Randeva Harpal </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marmon Tonya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jochelson Theresa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Luo Rosa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Monahan Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Madan Ajay </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ferrara-Cook Christine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Struthers R Scott </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Krasner Alan </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33231081" target="_blank">ACROBAT Edge : Safety and efficacy of switching injected SRLs to oral paltusotine in patients with acromegaly</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0021-972X">0021-972X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7197">1945-7197</a>)</span>: <span class="journal-volume">108</span> <span class="journal-issue">5</span> <span class="page"> pp e148-e159 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1210/clinem/dgac643" target="_blank" href="https://doi.org/10.1210/clinem/dgac643"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000897934300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000897934300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85143863023" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85143863023"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36353760" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36353760&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 43</span> | Független: 33 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 35 | Scopus jelölt:&nbsp;37 | WoS/Scopus jelölt:&nbsp;39 | DOI jelölt:&nbsp;43 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33231081&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33231081</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.15. 10:07 Áncsán Gizella (SE admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Crinetics Pharmaceuticals Inc. Funding text: This work was supported by Crinetics Pharmaceuticals Inc. The manuscript was written independently by the authors with medical writing support, which was funded by Crinetics Pharmaceuticals Inc and provided by Autumn Kelly, MA, and Donna Simcoe, MS, MS, MBA, CMPP, of Simcoe Consultants, Inc.</pre> </div></div>