https://m2.mtmt.hu/ hun 2026-09-24 04:53 JournalArticle 33228699 VALIDATED true Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, 44801, Germany Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, 44801, Germany Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, 44801, Germany HCEMM-Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, University of Budapest, Budapest, HU-1089, Hungary Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, HU-6720, Hungary Pharmahungary Group, Szeged, HU-6720, Hungary Cardiovascular and Metabolic Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, HU-1089, Hungary Cited By :1 Export Date: 12 June 2024 Correspondence Address: Hamdani, N.; Department of Cellular and Translational Physiology, Germany; email: nazha.hamdani@ruhr-uni-bochum.de Funding text 1: This research was funded by EU’s Horizon 2020 research and innovation program under grant agreement No. 739593 to NH; DFG (Deutsche Forschungsgemeinschaft) HA 7512/2-4 and HA 7512/2-1 to NH; NRDI Fund 2019-1.1.1-PIACI-KFI-2019-00367; Thematic Excellence Programme 2020-4.1.1.-TKP2020; New National Excellence Program UNKP-22-5-SZTE-542.; János Bolyai Research Fellowship of the Hungarian Academy of Sciences bo_481_21; EMBO short-term fellowship 8792; Heinrich und Alma Vogelsang Stiftung; German Academic Exchange Service (DAAD); European HCEMM HU26307383; Hungarian National Scientific Research Fund OTKA-138223, K139237. The study was supported also by the Hungarian National Cardiovascular Laboratory RRF-2.3.1-21-2022-00003. T.S. was supported by the Cooperative Doctoral Programme for Doctoral Scholarships (KDP-2020) of Ministry for Innovation and Technology financed from the National Research, Development and Innovation Fund. Funding text 2: We acknowledge support by the Open Access Publication Funds of the Ruhr-Universität Bochum. 0 false 2026-08-10T20:25:25.048+0000 2025-06-24T08:39:43.099+0000 2022-11-12T19:38:45.159+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Tichy Rita (SE_KK_Admin5_TR, admin) true 10026589 2026-06-16T08:52:34.947+0000 2025-06-24T08:39:43.280+0000 true 10082735 Tóth-Lipták Péter /api/admin/10082735 Admin Tóth-Lipták Péter (SZTE admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gömöri, Kamilla true true /api/journal/10052535 REVIEWED ANTIOXIDANTS 2076-3921 true false 10052535 false 10052535 true 2076-3921 Journal FOREIGN 11 11 2210 2210 16 2022 Volume-induced hypertrophy is one of the risk factors for cardiac morbidity and mortality. In addition, mechanical and metabolic dysfunction, aging, and cellular redox balance are also contributing factors to the disease progression. In this study, we used volume overload (VO), which was induced by an aortocaval fistula in 2-month-old male Wistar rats, and sham-operated animals served as control. Functional parameters were measured by transthoracic echocardiography at termination 4- or 8-months after VO. The animals showed hypertrophic remodeling that was accompanied by mechanical dysfunction and increased cardiomyocyte stiffness. These alterations were reversible upon treatment with glutathione. Cardiomyocyte dysfunction was associated with elevated oxidative stress markers with unchanged inflammatory signaling pathways. In addition, we observed altered phosphorylation status of small heat shock proteins 27 and 70 and diminished protease expression caspases 3 compared to the matched control group, indicating an impaired protein quality control system. Such alterations might be attributed to the increased oxidative stress as anticipated from the enhanced titin oxidation, ubiquitination, and the elevation in oxidative stress markers. Our study showed an early pathological response to VO, which manifests in cardiomyocyte mechanical dysfunction and dysregulated signaling pathways associated with enhanced oxidative stress and an impaired protein quality control system. 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(2022) ANTIOXIDANTS 2076-3921 11 11<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043713"><a href="/gui2/?type=authors&mode=browse&sel=10043713" target="_blank">Gömöri Kamilla (<span class="authorship-author-name">Gömöri Kamilla</span> <span class="authorAux-mtmt"> kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM- SE Kardiovaszkuláris Komorbiditások Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Herwig Melissa^* </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hassoun Roua^* </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Budde Heidi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mostafi Nusratul </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Delalat Simin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Modi Suvasini </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Begovic Merima </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067988"><a href="/gui2/?type=authors&mode=browse&sel=10067988" target="_blank">Szabados Tamara (<span class="authorship-author-name">Szabados Tamara</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028761"><a href="/gui2/?type=authors&mode=browse&sel=10028761" target="_blank">Pipis Judit (<span class="authorship-author-name">Pipis Judit</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028919"><a href="/gui2/?type=authors&mode=browse&sel=10028919" target="_blank">Farkas-Morvay Nikolett (<span class="authorship-author-name">Morvay Nikolett</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001636"><a href="/gui2/?type=authors&mode=browse&sel=10001636" target="_blank">Leprán István (<span class="authorship-author-name">Leprán István</span> <span class="authorAux-mtmt"> Gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055258"><a href="/gui2/?type=authors&mode=browse&sel=10055258" target="_blank">Kovács Árpád (<span class="authorship-author-name">Kovács Árpád</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mügge Andreas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027602"><a href="/gui2/?type=authors&mode=browse&sel=10027602" target="_blank">Görbe Anikó (<span class="authorship-author-name">Görbe Anikó</span> <span class="authorAux-mtmt"> orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022542"><a href="/gui2/?type=authors&mode=browse&sel=10022542" target="_blank">Bencsik Péter (<span class="authorship-author-name">Bencsik Péter</span> <span class="authorAux-mtmt"> Experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086357"><a href="/gui2/?type=authors&mode=browse&sel=10086357" target="_blank">Hamdani Nazha ✉ (<span class="authorship-author-name">Hamdani Nazha</span> <span class="authorAux-mtmt"> Medicine</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM- SE Kardiovaszkuláris Komorbiditások Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33228699" target="_blank">Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy</a></div> <div> <span class="journal-title">ANTIOXIDANTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-3921">2076-3921</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">11</span> <span class="page"> Paper 2210. 16 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/antiox11112210" target="_blank" href="https://doi.org/10.3390/antiox11112210"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000883366200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000883366200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85141789638" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85141789638"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36358581" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36358581&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="25530" target="_blank" href="http://publicatio.bibl.u-szeged.hu/25530"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 1 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33228699&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33228699</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-22-5-SZTE-542), (BO/481/21), Miokardiális remodelling metabolikus szindrómával komplikált poszt-infarktusos szívelégtelenségbe...(OTKA FK-138223) Támogató: NKFI, (K139237), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, Kooperatív Doktori Program(KDP-2020) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.06.24. 10:39 Tóth-Lipták Péter (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, 44801, Germany Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, 44801, Germany Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, 44801, Germany ...</pre> </div></div>